Extracellular traps as an important part of the pathogenesis in chronic rhinosinusitis

Abstract

Chronic rhinosinusitis is one of the most common diseases in the structure of ENT pathology. A combination of several factors often leads to the chronicity of this disease, which significantly complicates the choice of treatment tactics while maintaining persistent inflammation in the mucous membrane of the nasal cavity and paranasal sinuses. The emergence of new data on changes occurring at the cellular-molecular level significantly affects the understanding of the processes occurring during the pathogenesis of chronic rhinosinusitis and other diseases of the ENT organs. In recent years, more and more information has been accumulating on the role of neutrophils and eosinophils, as well as on such an immune response mechanism as the formation of extracellular traps in the structure of diseases of the upper and lower respiratory tract. The review presents current information on the effect of neutrophilic and eosinophilic extracellular traps on the chronic inflammatory process in the mucous membrane of the respiratory tract using the example of chronic rhinosinusitis.