Extracellular Vesicle-based Drug Delivery System Boosts Phytochemicals’ Therapeutic Effect for Neurodegenerative Diseases

Liao, Liuyue; Qiao, Hongzhi

doi:10.1097/hm9.0000000000000039

Cited by 10 publications

(6 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could potentially stop the progression of the disease. It is also possible to build nano vesicles to include diagnostic agents, which would allow for the imaging of lysosomal structures and functions concomitant with therapeutic intervention 117 . Finally, theranostic treatments for lysosomal dysfunction have an improved safety profile due to regulated release from nano vesicles, which minimises off-target effects and systemic toxicity.…”

Section: Nanotheranostics For Multiple Disease Of Herbal Bioactivesmentioning

confidence: 99%

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Setia,

Vallamkonda,

Challa

et al. 2024

Nanotheranostics

View full text Add to dashboard Cite

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they can be used. Since the herbal remedy is given through a dated and ineffective method of drug administration, its effectiveness is diminished. The novel form of medicine delivery has the potential to increase the effectiveness of herbal substances while decreasing their side effects. This is the main idea behind utilising different ways of drug delivery in herbal treatments. Several benefits arise from novel formulations of herbal compounds as compared to their conventional counterparts. These include enhanced penetrating ability into tissues, constant delivery of effective doses, and resistance to physical and chemical degradation. Controlled and targeted delivery that include herbal components allow for more traditional dosing while simultaneously increasing their efficacy. Enhancing the biodistribution and target site accumulation of systemically administered herbal medicines is the goal of nanomedicine formulations. The field of nanotheranostics has made significant advancements in the development of herbal compounds by combining diagnostic and therapeutic functions on a single nanoscale platform. It is critically important to create a theranostic nanoplatform that is derived from plants and is intrinsically "all-in-one" for single molecules. In addition to examining the mechanistic approach to nanoparticle synthesis, this review highlights the therapeutic effects of nanoscale phytochemical delivery systems. Furthermore, we have evaluated the scope for future advancements in this field, discussed several nanoparticles that have been developed recently for herbal imaging, and provided experimental evidence that supports their usage.

show abstract

Section: Nanotheranostics For Multiple Disease Of Herbal Bioactivesmentioning

confidence: 99%

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Setia,

Vallamkonda,

Challa

et al. 2024

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…Recently, herbal medicine has gained attention for its potential role in treating NDs. Numerous herbs and formulations have shown promise in clinical trials (Zhu et al 2022 ; Liu et al 2023a ) (Table 2 ). For instance, several herbs have shown potential benefits in alleviating cognitive decline and addressing the pathological hallmarks of AD.…”

Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

View full text Add to dashboard Cite

The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general health as it contributes to multiple aspects of host physiology. Recent research has revealed a dynamic connection between the gut microbiota and the central nervous system, that can influence neurodegenerative diseases (NDs). Indeed, imbalances in the gut microbiota, or dysbiosis, play a vital role in the pathogenesis and progression of human diseases, particularly NDs. Herbal medicine has been used for centuries to treat human diseases, including NDs. These compounds help to relieve symptoms and delay the progression of NDs by improving intestinal barrier function, reducing neuroinflammation, and modulating neurotransmitter production. Notably, herbal medicine can mitigate the progression of NDs by regulating the gut microbiota. Therefore, an in-depth understanding of the potential mechanisms by which herbal medicine regulates the gut microbiota in the treatment of NDs can help explain the pathogenesis of NDs from a novel perspective and propose novel therapeutic strategies for NDs. In this review, we investigate the potential neuroprotective effects of herbal medicine, focusing on its ability to regulate the gut microbiota and restore homeostasis. We also highlight the challenges and future research priorities of the integration of herbal medicine and modern medicine. As the global population ages, access to this information is becoming increasingly important for developing effective treatments for these diseases.

show abstract

“…Zhenzhu et al (2022) underline the potential for extracellular vesicles (EVs) to penetrate brain tissue and the BBB, specifically for treating neurodegenerative (ND) diseases. Extracellular vesicles are naturally produced by many cell types and include subtypes such as exosomes, microvesicles, apoptotic bodies, and oncosomes, all ranging in size and application [ 107 ]. Extracellular vesicles have been studied in the delivery of polyphenols to treat neurodegenerative diseases.…”

Section: Key Considerations and Challengesmentioning

confidence: 99%

Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms

et al. 2023

View full text Add to dashboard Cite

Neuroblastoma (NB) is an extracranial tumor of the peripheral nervous system arising from neural crest cells. It is the most common malignancy in infants and the most common extracranial solid tumor in children. The current treatment for high-risk NB involves chemotherapy and surgical resection followed by high-dose chemotherapy with autologous stem-cell rescue and radiation treatment. However, those with high-risk NB are susceptible to relapse and the long-term side effects of standard chemotherapy. Polyphenols, including the sub-class of flavonoids, contain more than one aromatic ring with hydroxyl groups. The literature demonstrates their utility in inducing the apoptosis of neuroblastoma cells, mostly in vitro and some in vivo. This review explores the use of various polyphenols outlined in primary studies, underlines the pathways involved in apoptotic activity, and discusses the dosage and delivery of these polyphenols. Primary studies were obtained from multiple databases with search the terms “neuroblastoma”, “flavonoid”, and “apoptosis”. The in vitro studies showed that polyphenols exert an apoptotic effect on several NB cell lines. These polyphenols include apigenin, genistein, didymin, rutin, quercetin, curcumin, resveratrol, butein, bisphenols, and various plant extracts. The mechanisms of the therapeutic effects include calpain-dependent pathways, receptor-mediated apoptosis, and, notably, and most frequently, mitochondrial apoptosis pathways, including the mitochondrial proteins Bax and Bcl-2. Overall, polyphenols demonstrate potency in decreasing NB proliferation and inducing apoptosis, indicating significant potential for further in vivo research.

show abstract

Extracellular Vesicle-based Drug Delivery System Boosts Phytochemicals’ Therapeutic Effect for Neurodegenerative Diseases

Cited by 10 publications

References 120 publications

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms

Contact Info

Product

Resources

About