Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy

Ruan, Jing; Miao, Xiaomin; Schlüter, Dirk; Wang, Xu

doi:10.1016/j.ymthe.2021.04.020

Cited by 49 publications

(36 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At present, the pathogenesis of inflammatory diseases of the central nervous system [including neurodegenerative diseases ( Ruan et al, 2021 ; Xiao et al, 2021 )] and autoimmune diseases ( Xu et al, 2022 ) has not been completely clarified, but more and more studies have begun to focus on the role of EVs in autoimmune diseases and research on treatment of EVs ( Guo et al, 2019 ; Chu et al, 2020 ; Dar et al, 2021 ; Saeedi et al, 2021 ; Xia et al, 2021 ). Studies have found that multiple miRNAs are involved in neuroinflammation and neurological diseases, such as Parkinson’s disease ( Xie et al, 2020c ), Alzheimer’s disease (AD) ( Dong et al, 2021 ), amyotrophic lateral sclerosis ( Liu et al, 2022 ), and depression ( Trotta et al, 2018 ; Chen and Wang, 2021 ).…”

Section: Diagnostic Value Of Extracellular Vesicle-derived Microrna I...mentioning

confidence: 99%

MicroRNAs in extracellular vesicles: Sorting mechanisms, diagnostic value, isolation, and detection technology

Fan

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are a class of short, single-stranded, noncoding RNAs, with a length of about 18–22 nucleotides. Extracellular vesicles (EVs) are derived from cells and play a vital role in the development of diseases and can be used as biomarkers for liquid biopsy, as they are the carriers of miRNA. Existing studies have found that most of the functions of miRNA are mainly realized through intercellular transmission of EVs, which can protect and sort miRNAs. Meanwhile, detection sensitivity and specificity of EV-derived miRNA are higher than those of conventional serum biomarkers. In recent years, EVs have been expected to become a new marker for liquid biopsy. This review summarizes recent progress in several aspects of EVs, including sorting mechanisms, diagnostic value, and technology for isolation of EVs and detection of EV-derived miRNAs. In addition, the study reviews challenges and future research avenues in the field of EVs, providing a basis for the application of EV-derived miRNAs as a disease marker to be used in clinical diagnosis and even for the development of point-of-care testing (POCT) platforms.

show abstract

Section: Diagnostic Value Of Extracellular Vesicle-derived Microrna I...mentioning

confidence: 99%

MicroRNAs in extracellular vesicles: Sorting mechanisms, diagnostic value, isolation, and detection technology

Fan

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…The ability to exchange information and to deliver bioactive substances to target cells gives EVs great potential for treating human disease [135]. EVs can be transferred to target organs, and thus are widely considered as natural nanocarriers, which show great prospect for application as drug targeting vectors [136][137][138][139][140][141][142]. These researches opened a new area in OS research, linking emerging nanocarrier EVs to the progression, prognosis, and treatment of OS.…”

Section: Evs In the Treatment Of Osteosarcomamentioning

confidence: 99%

Role of extracellular vesicles in osteosarcoma

Yang¹,

Liu²,

Wu³

et al. 2022

Int. J. Med. Sci.

View full text Add to dashboard Cite

Osteosarcoma is a malignant bone tumor characterized by the direct production of osteoid tissue from tumor cells. Extracellular vesicles are membranous vesicles released by cells into the extracellular matrix, which exist widely in various body fluids and cell supernatants, and stably carry some important signaling molecules. They are involved in cell communication, cell migration, angiogenesis and tumor cell growth. Increasing evidence has shown that extracellular vesicles play a significant role in osteosarcoma development, progression, and metastatic process, indicating that extracellular vesicles can be use as biomarker vehicles in the diagnosis and prognosis of osteosarcoma. This review discusses the basic biological characteristics of extracellular vesicles and focuses on their application in osteosarcoma.

show abstract

“…Many studies have shown that EVs exert vital effects on biological and pathological processes in the central nervous system (CNS), including neuronal differentiation, synaptic formation, glial crosstalk, and regulation of homeostatic signaling and the immune system ( 17 – 19 ). Moreover, it is well known that EVs are key mediators of CNS neuroimmune interactions and serve as essential regulators of neuroinflammation following TBI by carrying various kinds of cargo, such as DNA fragments, RNA, lipids, and proteins ( 20 , 21 ). In this review, we summarize the pro-inflammatory function of EVs and the overall effect of diverse cell type-derived EVs on TBI-associated neuroinflammation.…”

Section: Introductionmentioning

confidence: 99%

Neuroinflammation of traumatic brain injury: Roles of extracellular vesicles

Liu

Zhang²,

Cao³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a major cause of neurological disorder or death, with a heavy burden on individuals and families. While sustained primary insult leads to damage, subsequent secondary events are considered key pathophysiological characteristics post-TBI, and the inflammatory response is a prominent contributor to the secondary cascade. Neuroinflammation is a multifaceted physiological response and exerts both positive and negative effects on TBI. Extracellular vesicles (EVs), as messengers for intercellular communication, are involved in biological and pathological processes in central nervous system (CNS) diseases and injuries. The number and characteristics of EVs and their cargo in the CNS and peripheral circulation undergo tremendous changes in response to TBI, and these EVs regulate neuroinflammatory reactions by activating prominent receptors on receptor cells or delivering pro- or anti-inflammatory cargo to receptor cells. The purpose of this review is to discuss the possible neuroinflammatory mechanisms of EVs and loading in the context of TBI. Furthermore, we summarize the potential role of diverse types of cell-derived EVs in inflammation following TBI.

show abstract

Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy

Cited by 49 publications

References 130 publications

MicroRNAs in extracellular vesicles: Sorting mechanisms, diagnostic value, isolation, and detection technology

MicroRNAs in extracellular vesicles: Sorting mechanisms, diagnostic value, isolation, and detection technology

Role of extracellular vesicles in osteosarcoma

Neuroinflammation of traumatic brain injury: Roles of extracellular vesicles

Contact Info

Product

Resources

About