Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids

Bader, Johannes; Brigger, Finn; Leroux, Jean-Christophe

doi:10.1016/j.addr.2024.115461

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2024.115461

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Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids

Johannes Bader,

Finn Brigger,

Jean-Christophe Leroux

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MicroRNAs (miRNAs) maintain cellular homeostasis by blocking mRNAs by binding with them to fine-tune the expression of genes across numerous biological pathways. The 2024 Nobel Prize in Medicine and Physiology for discovering miRNAs was long overdue. We anticipate a deluge of research work involving miRNAs to repeat the history of prizes awarded for research on other RNAs. Although miRNA therapies are included for several complex diseases, the realization that miRNAs regulate genes and their roles in addressing therapies for hundreds of diseases are expected; but with advancement in drug discovery tools, we anticipate even faster entry of new drugs. To promote this, we provide details of the current science, logic, intellectual property, formulations, and regulatory process with anticipation that many more researchers will introduce novel therapies based on the discussion and advice provided in this paper.

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Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids

Cited by 2 publications

References 366 publications

What happened to BBR3464 and where to from here for multinuclear platinum-based anticancer drugs?

What happened to BBR3464 and where to from here for multinuclear platinum-based anticancer drugs?

MicroRNA Nobel Prize: Timely Recognition and High Anticipation of Future Products—A Prospective Analysis

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