Extracorporeal Immunoadsorption: Initial Experience in Human Systemic Lupus Erythematosus

Terman, David S.; Buffaloe, George; Cook, Gary; Sullivan, Michael; Mattioli, Carlos A.; Tillquist, Richard; Ayus, Juan Carlos

doi:10.1016/s0140-6736(79)92177-9

Cited by 107 publications

(32 citation statements)

References 16 publications

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“…Our results compliment those for protein A IA in the treatment of dialysis-dependent renal failure associated with RPGN and for SLE nephritis [23,24]. Patient 1 had a decline in renal function despite 3 weeks of immunosuppression with a high 182 Esnault/Testa/Jayne/Soulillou/Cuenel…”

Section: Discussionsupporting

confidence: 87%

Influence of Immunoadsorption on the Removal of Immunoglobulin G Autoantibodies in Crescentic Glomerulonephritis

Esnault

Testa

Jayne

et al. 1993

Nephron

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We report the treatment of 5 patients with crescentic glomerulonephritis by immunoadsorption using a protein A column. Two had systemic vasculitis, 2 antiglomerular basement membrane disease and 1 systemic lupus erythematosus (SLE). In the patients with systemic vasculitis and SLE, there was successful removal of autoantibodies and rapid control of disease; remission was maintained over a mean follow-up of 2 years. Clinical improvement was not seen in 2 patients with anti-glomerular basement membrane (GBM) disease who presented with dialysis-dependent renal failure. There were no apparent clinical side-effects related to the immunoadsorption procedure. Protein A immunoadsorption offers a semiselective alternative to plasma exchange and appears to be safe and efficient in removing pathogenic autoantibodies in crescentic glomerulonephritis without anti-GBM antibodies.

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Section: Discussionsupporting

confidence: 87%

Influence of Immunoadsorption on the Removal of Immunoglobulin G Autoantibodies in Crescentic Glomerulonephritis

Esnault

Testa

Jayne

et al. 1993

Nephron

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“…Using these regeneration procedures, a total of 4,006) ml of plasma was treated during each treatment session. Treatment sessions were repeated weekly, and each patient received 1 course of continuous anti-DNA apheresis, encompassing [2][3][4] sessions. Neither the plasma protein fraction, fresh frozen plasma, nor albumin was infused.…”

Section: Methodsmentioning

confidence: 99%

Continuous removal of anti‐DNA antibody, using a new extracorporeal immunoadsorption system, in patients with systemic lupus erythematosus

Suzuki

Hara

Harigai

et al. 1991

Arthritis & Rheumatism

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We performed selective and continuous immunoadsorption of anti‐DNA antibodies from the blood of 6 patients with systemic lupus erythematosus, using a newly developed extracorporeal immunoadsorption system equipped with twin dextran sulfate‐cellulose columns with an automated regenerating unit. Levels of anti‐DNA, which were initially high, were rapidly diminished after 2–4 apheresis procedures in each patient; in 3 patients with proteinuria and 4 patients with lymphocytopenia, these symptoms also improved. Analysis of the kinetics and the adsorbed amounts of anti‐DNA during the apheresis indicates that both the intravascular and the extravascular pool of anti‐DNA are reduced with this potent apheresis technique.

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“…Immunoadsorption was first applied to the treatment of SLE in 1979 when Terman et al tried to remove anti-DNA antibodies from a patient by plasma perfusion over a charcoal device [6]. Nicolaev [9].…”

Section: Introductionmentioning

confidence: 99%

Poly(hydroxyethyl methacrylate) based affinity membranes for in vitro removal of anti-dsDNA antibodies from SLE plasma

Uzun

Yavuz

Osman

et al. 2010

International Journal of Biological Macromolecules

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Extracorporeal Immunoadsorption: Initial Experience in Human Systemic Lupus Erythematosus

Cited by 107 publications

References 16 publications

Influence of Immunoadsorption on the Removal of Immunoglobulin G Autoantibodies in Crescentic Glomerulonephritis

Influence of Immunoadsorption on the Removal of Immunoglobulin G Autoantibodies in Crescentic Glomerulonephritis

Continuous removal of anti‐DNA antibody, using a new extracorporeal immunoadsorption system, in patients with systemic lupus erythematosus

Poly(hydroxyethyl methacrylate) based affinity membranes for in vitro removal of anti-dsDNA antibodies from SLE plasma

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