Extracorporeal Shock Wave Combined with Teriparatide-Loaded Hydrogel Injection Promotes Segmental Bone Defects Healing in Osteoporosis

Chen, Qi; Chen, Xia; Shi, Binbin; Chen, Chuyong; Yang, Chen; Mao, Guangfeng; Shi, Fangfang

doi:10.1007/s13770-021-00381-w

Cited by 13 publications

(11 citation statements)

References 42 publications

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“…As a serious public health problem, osteoporosis is a systemic bone metabolic disease characterized by reduced bone mass, low bone density and damaged bone microstructure and is accompanying an increased probability of fragility fractures [ 1 , 2 ]. The incidence of osteoporosis is 70% in people aged over 80 years and 15% in people over 50 years [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Hou

Tian

2022

Cell Commun Signal

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Osteoporosis is a common skeletal disease with marked bone loss, deterioration of the bone microstructure and bone fragility. An abnormal bone remodelling cycle with relatively increased bone resorption is the crucial pathophysiological mechanism. Bone remodelling is predominantly controlled by osteoblasts and osteoclasts, which are specialized cell types that are regulated by a variety of osteogenic and osteoclastic factors, including cytokines expressed within the bone microenvironment under local or systemic inflammatory conditions. Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the communication between cytokines and kinases by binding downstream gene promotors and is involved in a wide range of biological or pathological processes. Emerging evidence suggests that STAT3 and its network participate in bone remodelling and the development of osteoporosis, and this factor may be a potent target for osteoporosis treatment. This review focuses on the role and molecular mechanism of the STAT3 signalling pathway in osteogenesis, osteoclastogenesis and osteoporosis, particularly the bone-related cytokines that regulate the osteoblastic differentiation of bone marrow stromal cells and the osteoclastic differentiation of bone marrow macrophages by initiating STAT3 signalling. This review also examines the cellular interactions among immune cells, haematopoietic cells and osteoblastic/osteoclastic cells.

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Section: Introductionmentioning

confidence: 99%

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Hou

Tian

2022

Cell Commun Signal

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“…Hydrogels have been widely used in biomedical fields because of their bionic three-dimensional (3D) network structure and loaded bioactive substances as drug delivery systems ( Liu et al, 2018 ; Li et al, 2021b ; Li et al, 2022c ). Poloxamer 407 is a thermosensitive material with diversified capabilities, such as reversible thermo-sensitive property, drug encapsulation and sustained delivery ability, superior bioavailability, biocompatibility, and so on, which is considered to be an alternative injectable drug sustained-release system for enhancing bone regeneration and repair ( Bai et al, 2020a ; Chen et al, 2021 ). As illustrated in Figure 1A , the prepared hydrogel underwent a sol-gel transition with increasing the temperature from 4°C to 37°C.…”

Section: Resultsmentioning

confidence: 99%

Thermosensitive hydrogel loaded with concentrated growth factors promote bone repair in segmental bone defects

Zhang

Wang

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Treating critical-size bone defects beyond the body’s self-healing capacity is a challenging clinical task. In this study, we investigate the effect of concentrate growth factors (CGFs) loaded Poloxamer 407 hydrogel on the viability and osteogenic differentiation potential of bone marrow mesenchymal stem cells (BMSCs) and reconstruction of critical-size bone defects. In vitro, this CGFs-loaded thermosensitive hydrogel can significantly promote proliferation, maintain cell viability, and induce osteogenic differentiation of BMSCs by up-regulating the mineralization and alkaline phosphatase (ALP) activity, as well as gene markers, including runt-related transcription factor-2 (Runx-2), type I collagen (Col-1), osteocalcin (OCN), as well as osteopontin (OPN). In vivo, Micro-CT radiography analysis and histological detection demonstrated that the CGFs-loaded hydrogel significantly induced bone healing and reconstructed the medullary cavity structure in critical-size bone defect models. In conclusion, this strategy of transplantation of CGFs-loaded hydrogel promoted bone regeneration and prevented bone nonunion, so as to provide basis for clinical treatment for repairing critical-size bone defects.

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“…Chen et al studied the effect of the application of extracorporeal shock waves (ESW) together with the application of a hydrogel loaded with teriparatide (T-Gel), a drug used in the treatment of osteoporosis, on the activity and cell differentiation of osteoporosis-derived MSCs and their regenerative capacity. Their results showed that the combination of ESW and T-Gel significantly enhanced the viability, proliferation, migration and osteogenic differentiation of MSCs, thus improving the osteogenic activity of the microenvironment in osteoporotic defects [ 164 ].…”

Section: Treatment Of Osteoporosis and Novel Approachesmentioning

confidence: 99%

Current Status of the Diagnosis and Management of Osteoporosis

Aibar-Almazán

Voltes-Martínez

Castellote-Caballero

et al. 2022

IJMS

164

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Osteoporosis has been defined as the silent disease of the 21st century, becoming a public health risk due to its severity, chronicity and progression and affecting mainly postmenopausal women and older adults. Osteoporosis is characterized by an imbalance between bone resorption and bone production. It is diagnosed through different methods such as bone densitometry and dual X-rays. The treatment of this pathology focuses on different aspects. On the one hand, pharmacological treatments are characterized by the use of anti-resorptive drugs, as well as emerging regenerative medicine treatments such as cell therapies and the use of bioactive hydrogels. On the other hand, non-pharmacological treatments are associated with lifestyle habits that should be incorporated, such as physical activity, diet and the cessation of harmful habits such as a high consumption of alcohol or smoking. This review seeks to provide an overview of the theoretical basis in relation to bone biology, the existing methods for diagnosis and the treatments of osteoporosis, including the development of new strategies.

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Extracorporeal Shock Wave Combined with Teriparatide-Loaded Hydrogel Injection Promotes Segmental Bone Defects Healing in Osteoporosis

Cited by 13 publications

References 42 publications

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Thermosensitive hydrogel loaded with concentrated growth factors promote bone repair in segmental bone defects

Current Status of the Diagnosis and Management of Osteoporosis

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