EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE

Ibrahem, Nabaa M.

doi:10.22159/ijpps.2017v9i5.16875

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…The preliminary chemical screening tests approved the presence of alkaloids, polyphenolic compounds, flavonoids, tannins, polysaccharide and saponins in the extract of aerial parts of Iraqi Artemisia vulgaris. This is in agreement with studies reporting the presence of the above compounds [23].…”

Section: Discussionsupporting

confidence: 93%

Hepatoprotective activity of Artemisia vulgaris L. against Cisplatin induce hepatotoxicity in mice

2022

pnr

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Background: Artemisia vulgaris L. (Artemisia V.) has a great role in treatment of many diseases like gastrointestinal diseases, inflammation and fungal infections. Other important activity is antioxidant which put this plant as a good choice to reduce liver toxicity. In this study, the hepatoprotective effect of Iraqi Artemisia vulgaris L. against the liver toxic chemotherapy cisplatin were determined in mice.Methods: Two different doses of Iraqi Artemisia vulgaris L. extract were given to mice with and without cisplatin as a liver toxicity inducer. The blood level of liver enzymes ALT, AST, ALP and TSB were measured.Results: The elevation in blood level of liver enzymes reduced significantly in pre-treated mice with Artemisia extracted (200 and 400 mg/ Kg) and cisplatin, compared with mice group that received cisplatin alone.Conclusion: Hepatoprotective activities of Artemisia vulgaris L. extract were confirmed, and 400 mg/kg/day the extract was the most effective dose. This finding provides scientific evidence for the use of safe medicinal herbs such as A. vulgaris in the treatment of liver toxicity produced by other medications such as chemotherapy.

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Section: Discussionsupporting

confidence: 93%

Hepatoprotective activity of Artemisia vulgaris L. against Cisplatin induce hepatotoxicity in mice

2022

pnr

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“…The majority of skin cancers are caused by overexposure to ultraviolet radiation from the sun and artificial light sources including tanning bed usages. However, the mainstays for the prevention of skin cancer are focused on avoidance of exposure to excessive sun UV radiations and recommendations for the usage of protective hats and longsleeved clothing [25,26]. However, there is no effect of sunscreens on prior UV damage to the skin.…”

Section: Resultsmentioning

confidence: 99%

Structure-Based Docking Studies Toward Exploring the Potential Anticancer Activity of Morin Against Non-Melanoma Skin Cancer Therapeutic Drug Targets

Anjugam

Sridevi

Ts³

2018

Asian J Pharm Clin Res

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Objective: The purpose of this study is to explore the anticancer activity of morin compound against human cyclooxygenase-2 (COX-2) and peroxisome-proliferator-activated receptors (PPARs) isotypes (PPARα and PPARγ) through in silico molecular docking studies.Methods: The 3D structures of human COX-2 complexed with ibuprofen (PDB ID: 4PH9), PPARα complexed with a synthetic agonist (2S)-2-(4- methoxy-3-{[(pyren-1-yl carbonyl) amino] methyl} benzyl) butanoic acid (PDB ID: 3VI8) and PPARγ complexed indomethacin (PDB ID: 3ADX) were retrieved from protein databank. The cocrystallized sites were considered as binding sites, and the docking with morin compound was performed along with their respective cocrystals for each target and compared their interactions and binding affinities.Results: It is observed that the morin compound exhibited better binding energy of -32.9528 kJ/mol against PPARα followed by COX-2 (binding energy: −18.4311 kJ/mol) and PPARγ (binding energy: −17.4228 kJ/mol) when compared to their cocrystallized ligands.Conclusion: The present study suggests that morin compound might serve as potential alternatives in the prevention of skin cancers by showing better activity against PPARα.

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“…in addition to infections caused by microorganisms. 5 Tarragon can be used in a fresh state (leaves) and as a dried herb. 4 Its leaves produce a distinguishable flavor and aroma that another herb cannot replace, despite that sometimes lacking both flavor and aroma.…”

Section: Research Articlementioning

confidence: 99%

“…The genus has about 500 species which are most widely distributed in Asia (the center of origin) as well as Europe and North America. 4,5 This genus has been a source of herbal remedies and conventional drugs for centuries. Most Artemisia plant species are commonly used in curing some diseases like malaria, inflammatory diseases, neoplasms, and liver disease…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant and DNA Protection Activity of the Tarragon’s Methanolic Extract

Dawood¹,

Abdul-Jabar²,

Al-Fadal³

2022

IJDDT

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For many years plants were regarded as an important source of medical materials that are used extensively for treating and/or avoiding disease. Tarragons (Artemisia dracunculus) has a long history of medicinal uses and is applied for curative purposes. The important phytochemicals (flavonoid and tannin) in the methanolic extract of Tarragon’s dried leaves were estimated qualitatively and quantitatively, and the free radical scavenging activity against hydrogen peroxide was detected. Also, the methanolic extract’s ability to protect the human genomic DNA from Tarragon’s harmful compound was theoretically detected by doing a docking study for some tannin and flavonoid compounds in the DNA. And practically by incubating the human DNA with the Tarragon’s methanolic extract. Both flavonoid and tannin were found in Tarragon’s methanolic extract with about13.4 ± 0.133 mg of quercetin equivalent/gm of flavonoid and 17.7± 2.05 mg of tannic acid equivalent/gm of tannin. Additionally, the extract’s IC50 for H2O2 scavenging activity was about 3.42 ± 0.073 mg/mL, and the Tarragon’s extract’s highest inhibition percentage was about 34.37% compared with (48.57%) for ascorbic acid. Almost the Tarragon’s section has a protective and no damaging effect on DNA. That was confirmed by the high scores of binding energy between flavonoid and tannin compounds with DNA in the docking study. That means there is no direct damaging effect of edible tarragon leaves on the human genomic DNA, which may be strongly related to the content of active phytochemicals (tannin and flavonoids) in leaves.

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EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE

Cited by 5 publications

References 21 publications

Hepatoprotective activity of Artemisia vulgaris L. against Cisplatin induce hepatotoxicity in mice

Hepatoprotective activity of Artemisia vulgaris L. against Cisplatin induce hepatotoxicity in mice

Structure-Based Docking Studies Toward Exploring the Potential Anticancer Activity of Morin Against Non-Melanoma Skin Cancer Therapeutic Drug Targets

The Antioxidant and DNA Protection Activity of the Tarragon’s Methanolic Extract

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