Extraction, characterization and pharmacological activity and evaluation of various extracts of calotropis procera leaves

Abstract

All over Saudi Arabia, the medicinal plant Calotropis procera (C. procera) is a common wild shrub. We looked into the phytochemical makeup and several extracts of C. procera in this work. The presence of different ingredients was checked in all extracts. Table displays the findings of this exploratory phytochemical investigation. Following a phytochemical analysis, it was discovered that Calotropis procera contains alkaloids, steroids, flavonoids, tannins, and terpenoids. To separate the active compounds that might have pharmacologically active ingredients, a TLC chromatographic research was conducted. Ethanol and chloroform extract of Calotropis procera leaves demonstrate the presence of flavonoids and phenolic substances in preliminary phytochemical testing. Additionally, the TLC of both extracts reveals the presence of several phytometabolites. After collection of all fractions of both ethanol and chloroform extract, these fractions then screened for anti-rheumatic arthritis activity. Results depict that 150 mg/kg of crude extract and ethanolic fraction on 10th day showed more superior repression of paw edema i.e., 80.26% and 81.25% (p < 0.001) as compared to 79.56% reduction in paw edema by 100 mg/kg aspirin on 10th day.