Extraction, Chemical Composition, and Anticancer Potential of Origanum onites L. Essential Oil

Spyridopoulou, Katerina; Fitsiou, Eleni; Bouloukosta, Eleni; Tiptiri-Kourpeti, Angeliki; Vamvakias, Manolis; Oreopoulou, Antigoni; Papavassilopoulou, Eleni; Pappa, Aglaia; Chlichlia, Katerina

doi:10.3390/molecules24142612

Cited by 71 publications

(64 citation statements)

References 55 publications

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“…In a recent study, the essential oil of O. Onites isolated from plants collected in Northern Greece has shown dose-dependent antiproliferative activity in vitro, especially against the colon cancer cell line HT-29 (followed by A375, MCF-7 and HepG2 carcinomas). Treatment with the oil caused time-dependent cytotoxicity against HT-29 and CT26 cells (murine colon cancer cell line), attenuation of their migration, and apoptosis-like features, while oral administration for 13 days significantly inhibited the growth of CT26 tumors in mice [30].…”

Section: Resultsmentioning

confidence: 99%

Anticancer Activity of Essential Oils and Other Extracts from Aromatic Plants Grown in Greece

Fitsiou

Pappa

2019

Antioxidants

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Aromatic plants have a long and significant history in the traditional medicine of many countries. Nowadays, there is an increasing interest in investigating the biological properties of aromatic plant extracts mainly due to their diversity, high availability, and low toxicity. Greece is abundant in aromatic plants, which can be attributed to the country’s geographical position, the morphology of its landscape, and its numerous mountainous and insular areas. In the past 15 years, a number of aromatic plant extracts of Greek origin have been studied for their bioactivities, including their antiproliferative potential against different types of cancer. Although the pharmacological activities of specific species of Greek origin have been reviewed before, no gathered information on explicitly Greek species exist. In this review, we summarize existing data on the antiproliferative activity of extracts isolated from Greek aromatic plants and discuss their molecular mode(s) of action, where available, in order to identify promising extracts for future research and link chemical constituents responsible for their activity. We conclude that essentials oils are the most frequently studied plant extracts exhibiting high diversity in their composition and anticancer potential, but also other extracts appear to be worthy of further investigation for cancer chemoprevention.

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Section: Resultsmentioning

confidence: 99%

Anticancer Activity of Essential Oils and Other Extracts from Aromatic Plants Grown in Greece

Fitsiou

Pappa

2019

Antioxidants

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“…The essential oils extracted from O . onites possessed antiproliferative, anti‐migratory, and pro‐apoptotic properties against colon cancer (Spyridopoulou et al, 2019). These findings suggest that Origanum essential oils can be used as nutraceuticals for colon cancer prevention.…”

Section: Phytoconstituentsmentioning

confidence: 99%

Phytochemical constituents, biological activities, and health‐promoting effects of the genusOriganum

Sharifi‐Rad

Yılmaz

Antika

et al. 2020

Phytotherapy Research

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Origanum species are mostly distributed around the Mediterranean, Euro‐Siberian, and Iran‐Siberian regions. Since time immemorial, the genus has popularly been used in Southern Europe, as well as on the American continent as a spice now known all over the world under the name “oregano” or “pizza‐spice.” Origanum plants are also employed to prepare bitter tinctures, wines, vermouths, beer, and kvass. The major components of Origanum essential oil are various terpenes, phenols, phenolic acids, and flavonoids with predominant occurrence of carvacrol and thymol (with reasonable amounts of p‐cymen and ‐terpinene) or of terpinene‐4‐ol, linalool, and sabinene hydrate. Many species of Origanum genus are used to treat kidney, digestive, nervous, and respiratory disorders, spasms, sore throat, diabetes, lean menstruation, hypertension, cold, insomnia, toothache, headache, epilepsy, urinary tract infections, etc. Origanum essential oil showed potent bioactivities owing to its major constituents' carvacrol, thymol, and monoterpenes. Several preclinical studies evidenced its pharmacological potential as antiproliferative or anticancer, antidiabetic, antihyperlipidemic, anti‐obesity, renoprotective, antiinflammatory, vasoprotective, cardioprotective, antinociceptive, insecticidal, and hepatoprotective properties. Its nanotechnological applications as a promising pharmaceutical in order to enhance the solubility, physicochemical stability, and the accumulation rate of its essential oils have been investigated. However, Origanum has been reported causing angioedema, perioral dermatitis, allergic reaction, inhibition of platelet aggregation, hypoglycemia, and abortion. Conclusive evidences are still required for its clinical applications against human medical conditions. Toxicity analyses and risk assessment will aid to its safe and efficacious application. In addition, elaborate structure–activity studies are needed to explore the potential use of Origanum‐derived phytochemicals as promising drug candidates.

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“…Monoterpenes are the most widespread naturally occurring organic chemicals, being the main constituents of essential oils [12][13][14]. They show antioxidant, antimicrobial, analgesic, anxiolytic, and anticancer properties, and they are of interest as a source of therapeutic alternatives [15][16][17]. Perillyl alcohol, a naturally occurring monoterpene found in the essential oils of peppermint and lavender, has been widely studied [18], demonstrating effectiveness against a variety of human tumor cell lines [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

Souto

Zielińska

Souto

et al. 2020

IJMS

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In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (the HaCaT cell line). For the cell viability assay, the colorimetric 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used. Lim-SLNs with a loading capacity and encapsulation efficiency of 0.39% and 63%, respectively, were produced by high pressure homogenization. A mean particle size of 194 ± 3.4 nm and polydispersity index of 0.244 were recorded for the loaded Lim-SLNs, as compared to 203 ± 1.5 nm (PI 0.213) for the non-loaded (blank) SLNs. The loading of the monoterpene derivative into glycerol monostearate SLNs fitted into the zero-order kinetics, and ameliorated both lipid peroxidation and cytotoxicity in a keratinocyte cell line. A promising formulation for antioxidant and anti-tumoral activities is here proposed.

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Extraction, Chemical Composition, and Anticancer Potential of Origanum onites L. Essential Oil

Cited by 71 publications

References 55 publications

Anticancer Activity of Essential Oils and Other Extracts from Aromatic Plants Grown in Greece

Anticancer Activity of Essential Oils and Other Extracts from Aromatic Plants Grown in Greece

Phytochemical constituents, biological activities, and health‐promoting effects of the genusOriganum

(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

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