Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from<i>Grifola frondosa</i>

He, Xiaoling; Du, Xuezhu; Zang, Xiangyun; Dong, Lili; Gu, Zijian; Cao, Liping; Chen, Dafu; Keyhani, Nemat O.; Yao, Lindan; Qiu, Jian; Guan, Xiong

doi:10.1080/14786419.2015.1081197

Cited by 20 publications

(7 citation statements)

References 16 publications

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“…Ethanol extract of C. auriculata flowers showed the presence of resorcinol (0.66%) in this study which may be attributed to the antidandruff activity of plant. Inhibitory activity of citronellol against the fungi Trichophyton He et al, 2015). The anti-malassezial activity of ethanolic extract of C. auriculata and C. alata is due to one or other bioactive compounds identified through the GC-MS analysis.…”

Section: Resultsmentioning

confidence: 99%

Antidandruff activity of Cassia auriculata and Cassia alata through fatty acids mediated inhibition of Malassezia furfur

Prabhu¹,

Poonkodi²,

Pradeep³

et al. 2020

JANS

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Susceptibility of Malassezia furfur to certain medium chain fatty acids shed light onto novel strategies to control dandruff. This study explored antidandruff activity of the fatty acids and other bioactive compounds from flowers of Cassia auriculata and Cassia alata. The idea was supplementing the growth medium with fatty acids which are inhibitory to Malassezia so that plant-based antidandruff formulations could be developed based on the results. Chloroform and ethanolic flower extracts were tested there in vitro efficacy against M. furfur and the potential antidandruff compounds were identified by gas chromatography-mass spectrophotometry (GC-MS). Minimum inhibitory concentrations were determined for both the extracts and IC50 values of 50 and 88 µM for chloroform extract of C. auriculata and C. alata were recorded. For ethanol extract, IC50 values of 75 and 70 µM were exhibited by C. auriculata and C. alata, respectively. Inhibition of M. furfur through fatty acids from Cassia is the first report, and it is possible to include specific fatty acids in the growth media to inhibit the growth of Malassezia which could be later served as lead molecules in antidandruff formulations. Further, the presence of citronellol, pinitol, anthracenedione and chrysine in Cassia flower extracts and their antidandruff activity reported in this study needed further research on those compounds to formulate effective treatment of Malassezia associated diseases.

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Section: Resultsmentioning

confidence: 99%

Antidandruff activity of Cassia auriculata and Cassia alata through fatty acids mediated inhibition of Malassezia furfur

Prabhu¹,

Poonkodi²,

Pradeep³

et al. 2020

JANS

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“…pathogens in a plaque formation test. 48 There are two reports on inhibitory effect of HE extract against Helicobacter pylori in vitro. 49,50 HE also affected microbiota, which resulted in improved colonic health.…”

Section: Of Abm He and Gf Against Bacteria And Parasitesmentioning

confidence: 99%

“…A GF furanone is found to inhibit opportunistic Pseudomonas sp. pathogens in a plaque formation test 48 . There are two reports on inhibitory effect of HE extract against Helicobacter pylori in vitro 49,50 .…”

Section: Antimicrobial Effects Of Abm He and Gf Against Bacteria And Parasitesmentioning

confidence: 99%

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?

et al. 2020

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Medicinal mushrooms have documented effects against different diseases, including infections and inflammatory disorders. The related Basidiomycota Agaricus blaz ei Murill (AbM), Hericium erinaceus (HE), and Grifola frondosa (GF) have been shown to exert antimicrobial activity against viral agents, Gram‐positive and Gram‐negative bacteria, and parasites in vitro and in vivo. Since the mechanism is immunomodulatory and not antibiotical, the mushrooms should be active against multi‐drug resistant microbes as well. Moreover, since these Basidiomycota also have anti‐inflammatory properties, they may be suited for treatment of the severe lung inflammation that often follows COVID‐19 infection. An AbM‐based mushroom extract (Andosan™), also containing HE and GF, has been shown to significantly reduce bacteraemia and increase survival in mice with pneumococcal sepsis, and to improve symptoms and quality of life in IBD patients via an anti‐inflammatory effect. Hence, such mushroom extracts could have prophylactic or therapeutic effect against the pneumonic superinfection and severe lung inflammation that often complicates COVID‐19 infection. Here, we review antimicrobial and anti‐inflammatory properties of AbM, HE and GF mushrooms, which could be used for the battle against COVID‐19.

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“…Grifolaone A (68) was isolated from the edible mushroom Grifola frondosa. Interestingly, the hemiketal lactone was obtained in an optically active form and assigned as the S enantiomer [56]. The furanone was a potent inhibitor, MIC of 0.15 μg/mL, of the opportunistic human pathogen Pseudallescheria boydii and also had an MIC of 10 μg/mL against A. fumigatus.…”

Section: Natural Product Antifungal Leads From Fungimentioning

confidence: 99%

A Decade of Antifungal Leads from Natural Products: 2010–2019

et al. 2019

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In this review, we discuss novel natural products discovered within the last decade that are reported to have antifungal activity against pathogenic species. Nearly a hundred natural products were identified that originate from bacteria, algae, fungi, sponges, and plants. Fungi were the most prolific source of antifungal compounds discovered during the period of review. The structural diversity of these antifungal leads encompasses all the major classes of natural products including polyketides, shikimate metabolites, terpenoids, alkaloids, and peptides.

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Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, fromGrifola frondosa

Cited by 20 publications

References 16 publications

Antidandruff activity of Cassia auriculata and Cassia alata through fatty acids mediated inhibition of Malassezia furfur

Antidandruff activity of Cassia auriculata and Cassia alata through fatty acids mediated inhibition of Malassezia furfur

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?

A Decade of Antifungal Leads from Natural Products: 2010–2019

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