(Extraction of biomolecules using) aqueous biphasic systems formed by ionic liquids and aminoacids

Domı́nguez-Pérez, Montserrat; Tomé, Luciana I.N.; Freire, Mara G.; Marrucho, Isabel M.; Cabeza, O.; Coutinho, João A. P.

doi:10.1016/j.seppur.2010.01.008

Cited by 136 publications

(114 citation statements)

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“…39 Moreover, previous results for the extraction of ciprofloxacin and ciprofloxacin?HCl using imidazolium-based ionic liquid ABS and several amino acids as the salting-out agents confirmed low extraction efficiencies into the ionic-liquid-phase. 7 Therefore, the high partition coefficients obtained with cholinium-based ABS reveal that they are actually improved alternatives to traditional extraction methods and certainly deserve further attention from the biotechnology field.…”

Section: Partitioning Of Antibioticsmentioning

confidence: 99%

“…4 Most research has dealt with ABS made up of ionic liquids and typical organic/inorganic salts as feasible alternatives to polymer-salt systems 5 while, more recently, ionic liquids have also been shown to sucessfully replace traditional salts and to be strong enough to induce the saltingout of a polymeric-rich phase. 6 In addition, aqueous solutions of imidazolium-based ionic liquids also undergo liquid-liquid demixing in the presence of more benign species such as amino acids 7 and carbohydrates. 8 Ionic liquids (ILs) are low-temperature molten salts that can be designed for specific purposes by preselecting diverse combinations of cations and anions.…”

Section: Introductionmentioning

confidence: 99%

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Aqueous biphasic systems: a benign route using cholinium-based ionic liquids

et al. 2013

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acIonic liquid based aqueous biphasic systems (ABS) have been the focus of a significant amount of research in the last decade. However, only (moderately) toxic and poorly biodegradable ionic liquids have been explored hitherto. Focusing on the development of more benign and sustainable approaches, a novel class of ABS using cholinium based ionic liquids is proposed. For the first time, it is shown that a large assortment of cholinium based ionic liquids is capable of undergoing liquid liquid demixing in the presence of aqueous solutions with strong salting out species. In order to assess the applicability of these systems for separation purposes, the partitioning of two antibiotics and/or their hydrochloride forms was also investigated. Cholinium based ABS are shown to be improved routes for the extraction of pharmaceuticals, achieving complete extractions in a single step by way of the proper tailoring of the phase forming components and their concentrations in the aqueous media.

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Section: Partitioning Of Antibioticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aqueous biphasic systems: a benign route using cholinium-based ionic liquids

et al. 2013

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“…In this context, the replacement of organic solvents by ILs in the separation and purification of biomolecules such as amino acids, proteins, carbohydrates, lactic acid, antibiotics and alkaloids [1][2][3][4][5][6][7][8] , their use as reaction media in biocatalysis 9,10 , biosynthesis 11 and in the kinetic resolution of racemates [12][13][14] , as well as their role in the stabilization and activity of enzymes [15][16][17][18][19] have become crucial and urgent subjects in chemical and biochemical research.…”

Section: Introductionmentioning

confidence: 99%

“…With that aim, MD simulations were performed for aqueous solutions of an imidazolium-based IL (1-butyl-3-methylimidazolium bis(trifluoromethyl)sulfonyl imide, [C4mim][NTF 2 ], represented in Figure 1) with five different amino acids -glycine (Gly), alanine (Ala), valine (Val), isoleucine (ILe) and glutamic acid (Glu), all depicted in Figure 2. The imidazolium ion has been the most appealing and most frequently considered cation in the IL field and is known for its non-denaturing nature, low toxicity and reduced water pollution risk, when comprising a short alkyl chain 33,34 , and [NTF 2 ] has been selected by IUPAC as a benchmark anion.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics Simulation Studies of the Interactions between Ionic Liquids and Amino Acids in Aqueous Solution

et al. 2012

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This version is available at https://strathprints.strath.ac.uk/42553/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output.

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“…Organic solvents may be substituted by hydrophobic ILs as a second immiscible liquid phase with aqueous media [9] or by the use of ATPS incorporating hydrophilic ILs [6,[10][11][12][13]. Indeed, few years ago, Gutowski et al [12] showed that aqueous solutions of imidazolium-based ILs can form ATPS under the addition of appropriate inorganic salts, such as K 3 PO 4 .…”

Section: Introductionmentioning

confidence: 99%

Extraction of vanillin using ionic-liquid-based aqueous two-phase systems

Cláudio

Freire

et al. 2010

Separation and Purification Technology

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a b s t r a c tTo explore proper extractive solvents and to design an optimized separation process it is highly imperative to understand the molecular-based phenomena governing the solutes partitioning. Moreover, the development of new techniques for the biomolecules separation and purification, while maintaining their functional characteristics unchanged, is still ongoing. Therefore, in this work, the partition coefficients of vanillin, a compound with well-known organoleptic properties, were determined using improved ionicliquid-based aqueous two-phase systems (ATPS). Three main parameters were evaluated through the vanillin partitioning process: the ionic liquid (IL) cation and anion structure, the temperature of equilibrium and the available concentration of vanillin in the global system. In all systems and conditions tested, vanillin preferentially migrates for the IL-rich phase. In addition, the three studied parameters largely influence the vanillin partitioning. In an attempt to elucidate the thermodynamics of the partitioning process, the standard molar thermodynamic functions of transfer of vanillin were also determined based on the temperature dependence data. These data indicate that the partition of vanillin results from an interplay between enthalpic and entropic contributions where both the IL anion and more complex cations play an essential role. Moreover, viscosities and densities of both aqueous phases were experimentally measured at the mass fraction compositions for which the partition coefficients were determined. The results gathered in this work indicate that IL-based ATPS can be further employed in the extraction and purification of vanillin from different matrices, as confirmed by the large partition coefficients obtained and improved low viscosity systems.

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(Extraction of biomolecules using) aqueous biphasic systems formed by ionic liquids and aminoacids

Cited by 136 publications

References 29 publications

Aqueous biphasic systems: a benign route using cholinium-based ionic liquids

Aqueous biphasic systems: a benign route using cholinium-based ionic liquids

Molecular Dynamics Simulation Studies of the Interactions between Ionic Liquids and Amino Acids in Aqueous Solution

Extraction of vanillin using ionic-liquid-based aqueous two-phase systems

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