Extraction of Mangiferin from the Leaves of the Mango Tree Mangifera indica and Evaluation of its Biological Activity in Terms of Blockade of α-glucosidase

Vo, T-H; Nguyen, Thi-Hong-Anh; Nguyen, Quoc Hung; Ушакова, Н. А.

doi:10.1007/s11094-017-1697-x

Cited by 19 publications

(12 citation statements)

References 10 publications

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“…Similarly, inhibition of NO release was also reported for 2,4′,6-trihydroxy-4-methoxybenzophenone (25) (Pan et al 2016) which additionally showed DPPH radical scavenging effects (Pan et al 2016) as well as induction of apoptosis in HT-29 colon carcinoma cells (Lay et al 2014). Mangiferin (8), the main xanthone in I. adriatica rhizomes, revealed several activities related to antidiabetic effects, like inhibiting endothelial insulin resistance (Xu et al 2017) or α-glucosidase inhibition (Vo et al 2017) as well as anti-inflammatory and antidepressant action (Cao et al 2017). Irilone (34) was shown to possess α-amylase inhibitory effects which would support antidiabetic action (Ibrahim et al 2017).…”

Section: Quantitative Estimate Of Major Compounds In I Adriatica Rhimentioning

confidence: 67%

Metabolic profiling of rhizomes of native populations of the strictly endemic Croatian species Iris adriatica

Alperth

Mitić

Mayer

et al. 2018

Plant Biosystems - An International Journal Dealing with all As

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which is 4 to 7 cm long. Tepals are usually of different shades of yellow and less frequent of violet or purple colour. The outer tepals have multicellular coloured hairs (so called "beard"). Plants bloom very early in the spring, in March and April. Its distribution area is limited to the Croatian part of the Mediterranean areacentral Dalmatia, the surroundings of the cities of Drniš, Unešić, Zadar, Šibenik and Split, as well as the nearby islands (e.g. Vir, Čiovo, Brač, Kornati etc.). Populations of I. adriatica are generally small, and in the past few years, some of them have disappeared or decreased. For this reason, I. adriatica belongs to the NT (near threatened) IUCN category in the Croatian Red Book of Vascular Plants (Nikolić 2017). However, the plant is suitable for cultivation in greenhouses and in vitro (Vršek et al. 2004; Kereša et al. 2009), and therefore, besides an ornamental use, it has a good perspective to become a useful medical plant, as it was shown for some other Iris taxa (Kukula-Koch et al. 2015; Venditti et al. 2017).

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Section: Quantitative Estimate Of Major Compounds In I Adriatica Rhimentioning

confidence: 67%

Metabolic profiling of rhizomes of native populations of the strictly endemic Croatian species Iris adriatica

Alperth

Mitić

Mayer

et al. 2018

Plant Biosystems - An International Journal Dealing with all As

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“…34 Other studies revealed that mangiferin ( 4 ) is more active than the positive controls used. As an example, Vo et al 44 reported an IC 50 value of 5.82 μg mL −1 ≈ 13.78 μM (acarbose, IC 50 = 199.47 μg mL −1 , ≈309 μM) and Shi et al 45 reported an IC 50 value of 358.54 μM (acarbose, IC 50 = 479.2 μM) for mangiferin ( 4 ), while other authors reported IC 50 values in the mM range. 37,46 To complement this information, studies conducted on mangiferin ( 4 ) against both α-amylase and α-glucosidase enzymes concluded that the xanthone had more potential to inhibit α-glucosidase than α-amylase as reported by Ganogpichayagrai et al (IC 50 = 0.5813 mg mL −1 ≈ 1.38 mM and 1.0485 mg mL −1 ≈ 2.48 mM, respectively) 37 and by Dineshkumar et al (IC 50 = 41.88 μg mL −1 ≈ 99.2 μM and 74.35 μg mL −1 ≈ 176.0 μM, respectively).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by hydroxylated xanthones

et al. 2022

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“…In contrast, the third mangiferin study that used rat intestinal AG [109] reported a very high IC 50 value of 52 171.37 µM but in a spectrophotometric assay with PNPG as substrate. In other studies on mangiferin [110,[117][118][119][120], the biological source of AG was unclear or not mentioned, and it is, therefore, difficult to comment on the data or the possible influences of assay conditions.…”

Section: Overview Of Screening Studies For Novel Agismentioning

confidence: 99%

Critical Assessment of In Vitro Screening of α-Glucosidase Inhibitors from Plants with Acarbose as a Reference Standard

Miller

2021

Planta Med

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Postprandial hyperglycemia is treated with the oral antidiabetic drug acarbose, an intestinal α-glucosidase inhibitor. Side effects of acarbose motivated a growing number of screening studies to identify novel α-glucosidase inhibitors derived from plant extracts and other natural sources. As “gold standard”, acarbose is frequently included as the reference standard to assess the potency of these candidate α-glucosidase inhibitors, with many outperforming acarbose by several orders of magnitude. The results are subsequently used to identify suitable compounds/products with strong potential for in vivo efficacy. However, most α-glucosidase inhibitor screening studies use enzyme preparations obtained from nonmammalian sources (typically Saccharomyces cerevisiae), despite strong evidence that inhibition data obtained using nonmammalian α-glucosidase may hold limited value in terms of identifying α-glucosidase inhibitors with actual in vivo hypoglycemic potential. The aim was to critically discuss the screening of novel α-glucosidase inhibitors from plant sources, emphasizing inconsistencies and pitfalls, specifically where acarbose was included as the reference standard. An assessment of the available literature emphasized the cruciality of stating the biological source of α-glucosidase in such screening studies to allow for unambiguous and rational interpretation of the data. The review also highlights the lack of a universally adopted screening assay for novel α-glucosidase inhibitors and the commercial availability of a standardized preparation of mammalian α-glucosidase.

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Extraction of Mangiferin from the Leaves of the Mango Tree Mangifera indica and Evaluation of its Biological Activity in Terms of Blockade of α-glucosidase

Cited by 19 publications

References 10 publications

Metabolic profiling of rhizomes of native populations of the strictly endemic Croatian species Iris adriatica

Metabolic profiling of rhizomes of native populations of the strictly endemic Croatian species Iris adriatica

Inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by hydroxylated xanthones

Critical Assessment of In Vitro Screening of α-Glucosidase Inhibitors from Plants with Acarbose as a Reference Standard

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