Extraction of stevioside using aqueous two-phase systems formed by choline chloride and K 3 PO 4

Abolghasembeyk, T.; Shahriari, Sh.; Salehifar, M

doi:10.1016/j.fbp.2016.12.011

Cited by 17 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ionic liquids constitute another class of substances that can be highlighted for use in the formation of new ATPSs, although disadvantages are that the costs associated with these compounds may be high, while some of the ionic-liquid-forming cations may be toxic and nonbiodegradable. Consequently, attention has been focused on a new class of ionic liquids, based on the choline cation, that are more economically viable, safer in the environment, and easier to handle than the most commonly used ionic liquids. − An example is choline chloride, a tetravalent ammonium salt, which remains poorly studied. − Due to its properties, it is highly suitable for use in ATPSs, enabling systems to be obtained that comply with the principles of green chemistry.…”

Section: Introductionmentioning

confidence: 99%

Liquid–Liquid Equilibrium of Aqueous Two-Phase Systems Composed of Nonionic Surfactant (Triton X-100, Triton X-165, or Triton X-305) and Choline Chloride

et al. 2019

View full text Add to dashboard Cite

The study of aqueous two-phase systems (ATPSs) formed by ionic liquids based on the choline cation and nonionic surfactants has received attention in recent years because of the biodegradability and nontoxicity of their components. In this work, liquid–liquid equilibrium data were obtained for ATPSs composed of Triton X (Triton X-100, Triton X-165, and Triton X-305), choline chloride, and water, at 298.15, 313.15, and 328.15 K. In general, these systems presented a top phase rich in choline chloride and a bottom phase rich in surfactant, although the phenomenon of phase inversion was observed for a specific thermodynamic condition of the system formed by Triton X-165. It was observed that increase of the temperature led to an increase of the biphasic region, indicating an endothermic phase separation process. In addition, higher hydrophobicity of the surfactant increased its ability to promote phase segregation (the biphasic region increased in the following order: Triton X-100 > Triton X-165 > Triton X-305). The reliability of the equilibrium data was confirmed using the Othmer–Tobias and Bancroft correlations.

show abstract

Section: Introductionmentioning

confidence: 99%

Liquid–Liquid Equilibrium of Aqueous Two-Phase Systems Composed of Nonionic Surfactant (Triton X-100, Triton X-165, or Triton X-305) and Choline Chloride

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Dyes are heavily used in the textile industry but are prominent pollutants, and work toward green decontamination has materialized (36,37). ATPSs allow for low-cost purification of commercially relevant molecules, such as vanillin (38), a phenolic extract from vanilla beans, and stevioside (39), a glycoside and natural sweetener. Although carbon nanotubes were used as an additive to enhance vanillin partitioning, they themselves can be rapidly isolated according to size using PEG/dextran (40,41).…”

Section: Small Molecules and Polysaccharidesmentioning

confidence: 99%

Aqueous Two-Phase Systems and Microfluidics for Microscale Assays and Analytical Measurements

Ahmed

Yamanishi

Kojima

et al. 2021

Annual Rev. Anal. Chem.

View full text Add to dashboard Cite

Phase separation is a common occurrence in nature. Synthetic and natural polymers, salts, ionic liquids, surfactants, and biomacromolecules phase separate in water, resulting in an aqueous two-phase system (ATPS). This review discusses the properties, handling, and uses of ATPSs. These systems have been used for protein, nucleic acid, virus, and cell purification and have in recent years found new uses for small organics, polysaccharides, extracellular vesicles, and biopharmaceuticals. Analytical biochemistry applications such as quantifying protein–protein binding, probing for conformational changes, or monitoring enzyme activity have been performed with ATPSs. Not only are ATPSs biocompatible, they also retain their properties at the microscale, enabling miniaturization experiments such as droplet microfluidics, bacterial quorum sensing, multiplexed and point-of-care immunoassays, and cell patterning. ATPSs include coacervates and may find wider interest in the context of intracellular phase separation and origin of life. Recent advances in fundamental understanding and in commercial application are also considered. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

“…The partitioning of nisin in the ATPs with or without nanoparticles was obtained through the experimental procedure that can be readily found elsewhere. , …”

Section: Experimental Sectionmentioning

confidence: 99%

“…Thanks to the compatibility of the components of ATPSs with biological materials as well as the water-rich phases, the use of these systems for extraction, separation, purification, and refinement of labile biomolecules is growing more and more popular . There are a great number of studies on the applications of ATPSs in the extraction and purification of antibiotics, amino acids, and enzymes . The introduction of additives into ATPSs is one of the most effective ways to enhance the efficiency of separation processes. , In this fashion, the application of nanoparticles to improve the partitioning of biomolecules, as an alternative accessible method, has recently been developed. , …”

Section: Introductionmentioning

confidence: 99%

Separation Process of Nisin Using Aqueous Two-Phase Systems: A New Approach Featuring Nanoparticles

2020

View full text Add to dashboard Cite

In this study, to improve the efficiency of an aqueous two-phase system (ATPS), a different scenario has been proposed. To this purpose, an endeavor has been undertaken to find a nanoparticle suitable for designing a process of favorable economic separation as well as to unravel the mechanism of the partitioning of nisin along with nanoparticle. First, the capabilities of several different nanoparticles were assessed. These nanoparticles were regarded as additives apt to improve nisin partitioning in the ATPS containing polyethylene glycol (with different molecular weights) and a mixture of potassium hydrogen phosphate and potassium dihydrogen phosphate. The impact of the addition of the modified nanographite (in very small amounts) on the improvement of the nisin partition coefficient in polymer/salt ATPS was quite remarkable. The results showed that the partition coefficient of nisin was increased up to 610% (eight times more than that of the ATPS without nanoparticles) in PEG 10 000 + KH2PO4/K2HPO4 + H2O. The mechanism of the partitioning of nisin along with nanoparticle dominating the boost in the partition coefficient was explained by the structural investigations.

show abstract

Extraction of stevioside using aqueous two-phase systems formed by choline chloride and K 3 PO 4

Cited by 17 publications

References 30 publications

Liquid–Liquid Equilibrium of Aqueous Two-Phase Systems Composed of Nonionic Surfactant (Triton X-100, Triton X-165, or Triton X-305) and Choline Chloride

Liquid–Liquid Equilibrium of Aqueous Two-Phase Systems Composed of Nonionic Surfactant (Triton X-100, Triton X-165, or Triton X-305) and Choline Chloride

Aqueous Two-Phase Systems and Microfluidics for Microscale Assays and Analytical Measurements

Separation Process of Nisin Using Aqueous Two-Phase Systems: A New Approach Featuring Nanoparticles

Contact Info

Product

Resources

About