Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume

Li, Hongyan; Wang, Yingxing; Wang, Chao; Zhang, Shaohan; Li, Shenghui; Zhou, Guoqiang; Wang, Shuxiang; Zhang, Jinchao

doi:10.1007/s10719-016-9753-4

Cited by 27 publications

(8 citation statements)

References 45 publications

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“…Proposed structure of Se‐containing polysaccharide generated by the nitric acid–sodium selenite (HNO 3 ‐Na 2 SeO 3 ) method with 1‐6‐linked polysaccharide. Selenylation with ‐HSeO 3 group can occur at C‐2, C‐3, and C‐4 positions and at C‐1 position of the reducing sugar (H. Li et al., 2017). …”

Section: Selenosugar and Selenopolysaccharidementioning

confidence: 99%

Selenosugar, selenopolysaccharide, and putative selenoflavonoid in plants

Qi,

Duan,

2024

Comp Rev Food Sci Food Safe

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Selenium (Se) is a naturally occurring essential micronutrient that is required for human health. Selenium supports cellular antioxidant defense and possesses bioeffects such as anti‐inflammation, anti‐cancer, anti‐diabetic, and cardiovascular and liver protective effects arising from Se‐enhanced cellular antioxidant activity. Past studies on Se have focused on elucidating Se speciation in foods, biofortification strategies to produce Se‐enriched foods to address Se deficiency in the population, and the biochemical activities of Se in health. The bioavailability and toxicity of Se are closely correlated to its chemical forms and may exhibit varying effects on body physiology. Selenium exists in inorganic and organic forms, in which inorganic Se such as sodium selenite and sodium selenate is more widely available. However, it is a challenge for safe and effective supplementation considering inorganic Se low bioavailability and high cytotoxicity. Organic Se, by contrast, exhibits higher bioavailability and lower toxicity and has a more diverse composition and structure. Organic Se exists as selenoamino acids and selenoproteins, but recent research has provided evidence that it also exists as selenosugars, selenopolysaccharides, and possibly as selenoflavonoids. Different food categories contain various Se compounds, and their Se profiles vary significantly. Therefore, it is necessary to delineate Se speciation in foods to understand their impact on health. This comprehensive review documents our knowledge of the recent uncovering of the existence of selenosugars and selenopolysaccharides and the putative evidence for selenoflavonoids. The bioavailability and bioactivities of these food‐derived organic Se compounds are highlighted, in addition to their composition, structural features, and structure–activity relationships.

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Section: Selenosugar and Selenopolysaccharidementioning

confidence: 99%

Selenosugar, selenopolysaccharide, and putative selenoflavonoid in plants

Qi,

Duan,

2024

Comp Rev Food Sci Food Safe

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“…And water decoction and ethanol precipitation method is the most common technique for extracting Se-polysaccharides from biological matrix. The method usually exhibited the following advantages: (1) low solvent consumption, (2) low cost, and (3) operating simplicity [ 28 , 29 ]. Ultrasonic extraction was also used to isolate Se-polysaccharides from Se-enriched Lyophyllum decastes .…”

Section: Techniques For Preparing Natural and Synthetic Se-polysaccharidesmentioning

confidence: 99%

“…Moreover, its operation is simpler than the second method [ 39 ], although it is more time-consuming. For instance, selenylation of glucan from Castanea mollissima fruits with Se content of 574 μg/g was performed using NA-SS system at 65 °C for 10 h [ 29 ]. Likely, selenylation of polysaccharides from Capparis spinosa with Se content of 2438–5545 μg/g was conducted using HA-SS system at 65 °C for 10 h [ 40 ].…”

Section: Techniques For Preparing Natural and Synthetic Se-polysaccharidesmentioning

confidence: 99%

“…It is already well established that function of biological macromolecules (e.g., polysaccharides) is closely related to their chemical structure [ 29 ]. Consequently, it is necessary to thoroughly analyzed chemical structure of Se-polysaccharides by various methods and to reveal their structure–activity relationship.…”

Section: Structural Characterization Of Se‑polysaccharidesmentioning

confidence: 99%

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Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides

Duan

Yang

Zhang

et al. 2021

Biol Trace Elem Res

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“…[270], Hericium erinaceus [271], Glycyrrhiza uralensis [272], Epimedium sp. [273], Isatis indigotica root [273], Schisandra chinensis [243], Capparis spionosa [274], Cynomorium songaricum [256], Murus alba [275], Castanea mollissima [276], Rhizobium sp. [277], Artemisia sphaerocephala [244], Potentilla anserina [278], Lactococcus lactis subsp.…”

Section: Se-esters-selenites and Diselenites Of Polysaccharidesmentioning

confidence: 99%

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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Selenosugars are a group of sugar derivatives of great structural diversity (e.g., molar masses, selenium oxidation state, and selenium binding), obtained as a result of biosynthesis, chemical modification of natural compounds, or chemical synthesis. Seleno-monosaccharides and disaccharides are known to be non-toxic products of the natural metabolism of selenium compounds in mammals. In the case of the selenium-containing polysaccharides of natural origin, their formation is also postulated as a form of detoxification of excess selenium in microorganisms, mushroom, and plants. The valency of selenium in selenium-containing polysaccharides can be: 0 (encapsulated nano-selenium), IV (selenites of polysaccharides), or II (selenoglycosides or selenium built into the sugar ring to replace oxygen). The great interest in Se-polysaccharides results from the expected synergy between selenium and polysaccharides. Several plant- and mushroom-derived polysaccharides are potent macromolecules with antitumor, immunomodulatory, antioxidant, and other biological properties. Selenium, a trace element of fundamental importance to human health, has been shown to possess several analogous functions. The mechanism by which selenium exerts anticancer and immunomodulatory activity differs from that of polysaccharide fractions, but a similar pharmacological effect suggests a possible synergy of these two agents. Various functions of Se-polysaccharides have been explored, including antitumor, immune-enhancement, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, and neuroprotective activities. Due to being non-toxic or much less toxic than inorganic selenium compounds, Se-polysaccharides are potential dietary supplements that could be used, e.g., in chemoprevention.

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Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume

Cited by 27 publications

References 45 publications

Selenosugar, selenopolysaccharide, and putative selenoflavonoid in plants

Selenosugar, selenopolysaccharide, and putative selenoflavonoid in plants

Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

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