Extraction Socket Augmentation with Autologous Platelet-Rich Fibrin (PRF): The Rationale for Socket Augmentation

Ucer, Cemal; Khan, Rabia Sannam

doi:10.3390/dj11080196

Cited by 8 publications

(9 citation statements)

References 72 publications

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“…Significantly, the success rate as well as the marginal bone levels of implants placed in alveolar ridges following SA were found to be comparable with that of implants placed in untreated sockets. A review of the rationale for SA with PRF was presented by the current authors Ucer et al [46]. The results of the current case studies are consistent with the findings of Sisti et al [44] and Marda et al [45].…”

Section: Discussionsupporting

confidence: 86%

Extraction Socket Augmentation with Autologous Platelet Rich Fibrin (PRF): Case Reports and the Rationale for PRF

Ucer,

Khan

2023

Preprint

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Alveolar bone atrophy after tooth extraction presents significant difficulties when planning delayed-immediate implant treatment to replace a lost tooth. Socket augmentation is an effective therapy that limits the post extraction volumetric changes and facilitates implant placement whilst reducing the need for staged grafting. However, socket augmentation and osteoconductive graft conversion is a slow process that could take 4-6 months. PRF and its variants have significant bio-enhancement effect on wound healing and regeneration through release of platelet drived growth factors, bioactive substances, cytokines. Leukocytes in PRF also play a significant role in enhancing tissue regeneration as part of osteo-immune response. Use of PRF during socket augmentation is highly effective in enhancing extraction site healing and graft integration by angiogenesis, cell proliferation, recruitment, and differentiation through release of growth factors and bioactive substances mediated by platelets and leukocytes. PRF with SA is recommended as an adjunct to SA as a sole biomaterial or in combination with xenograft or allograft bone substitutes to enhance tissue regeneration and to reduce risk of infection, osteitis and postoperative pain in extraction sockets

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Section: Discussionsupporting

confidence: 86%

Extraction Socket Augmentation with Autologous Platelet Rich Fibrin (PRF): Case Reports and the Rationale for PRF

Ucer,

Khan

2023

Preprint

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“…The enriched content of growth factors and bioactive components within PRF notably amplifies socket healing and tissue regeneration. This presents a viable alternative to conventional grafting materials, which necessitate a significantly prolonged integration period before proceeding with implant placements [ 18 ].…”

Section: Main Textmentioning

confidence: 99%

Advancements in alveolar bone grafting and ridge preservation: a narrative review on materials, techniques, and clinical outcomes

Kim,

Kim

2024

Maxillofac Plast Reconstr Surg

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This narrative review systematically explores the progression of materials and techniques in alveolar ridge preservation (ARP). We commence by delineating the evolution from traditional ARP methods to cutting-edge alternatives, including platelet-rich fibrin, injectable bone repair materials, and hydrogel systems. Critical examination of various studies reveals these innovative approaches not only accelerate bone healing but also significantly improve patient-reported outcomes, such as satisfaction, pain perception, and overall quality of life. Emphasis is placed on the correlation between advanced ARP techniques and enhanced patient comfort and clinical efficacy, underscoring their transformative potential in dental implantology. Highlighting the effectiveness of ARP, the implant survival rate over a span of 5 to 7 years was high, showcasing the reliability and success of these methods. Further, patients expressed high aesthetic satisfaction with the soft tissue outcome, evidenced by an average visual analog scale (VAS) score of 94. This positive aesthetic appraisal is linked to the clinical health of implants, potentially due to the employment of tooth-supported surgical guides. The economic analysis reveals a varied cost range for bone graft substitutes ($46.2 to $140) and socket sealing materials ($12 to $189), with a noteworthy correlation between the investment in barrier membranes and the diminished horizontal and vertical ridge resorption. This suggests that membrane usage significantly contributes to preserving ridge dimensions, offering a cost-effective strategy for enhancing ARP outcomes. In conclusion, this review illuminates the significant advancements in ARP, highlighting the shift towards innovative materials and techniques that not only promise enhanced bone regeneration and reduced healing times but also improve patient satisfaction and aesthetic outcomes. The documented high implant survival rate and the beneficial economic implications of membrane use further validate the effectiveness of contemporary ARP strategies, paving the way for their broader adoption in dental implantology.

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“…A variety of bone grafting materials have been used for socket grafting (ARP-SG) including allografts, xenografts, alloplasts, autogenous bone, and other growth factors. Most systematic reviews agree that ARP-SG reduces alveolar bone resorption in horizontal and vertical dimensions [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Long-Term Esthetic and Radiographic Outcome of Implants Placed in the Anterior Maxilla after Ridge Preservation, Combining Bovine Xenograft with Collagen Matrix

Batas,

Xanthopoulou,

Gnigou

et al. 2024

Dentistry Journal

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The objective of the study was to evaluate the long-term esthetic and radiographic results of implants placed in the anterior maxilla after ridge preservation, combining bovine xenograft with collagen matrix. Fifteen patients who required a single tooth extraction because of fracture, root resorption, or extended caries were included in the study. After extraction, all sites were grafted using Deproteinized Bovine Bone Mineral (DBBM) with collagen and covered by a resorbable collagen matrix (CM). Five months after socket grafting, implants were successfully installed. The implant diameter range was between 3.8 and 4.2 mm. All patients were monitored for over 7 years, both clinically and radiographically. Three independent observers evaluated the long-term esthetic outcome, employing the Pink Esthetic Score (PES) technique. Over a period exceeding seven years, a 100% survival rate was observed for all 15 implants, with minimal marginal bone loss. The mean PES was 11.40 (±1.44) at the first assessment and 11.38 (±1.63) at the second assessment. The difference was not statistically significant (p = 0.978), and the scores of PES measurements indicated excellent esthetic results even after seven years. Based on these preliminary results, it seems that placing collagen bovine bone in a fresh extraction socket, covered with a collagen matrix, can preserve the alveolar ridge and provide long-term stable esthetic results.

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Extraction Socket Augmentation with Autologous Platelet-Rich Fibrin (PRF): The Rationale for Socket Augmentation

Cited by 8 publications

References 72 publications

Extraction Socket Augmentation with Autologous Platelet Rich Fibrin (PRF): Case Reports and the Rationale for PRF

Extraction Socket Augmentation with Autologous Platelet Rich Fibrin (PRF): Case Reports and the Rationale for PRF

Advancements in alveolar bone grafting and ridge preservation: a narrative review on materials, techniques, and clinical outcomes

The Long-Term Esthetic and Radiographic Outcome of Implants Placed in the Anterior Maxilla after Ridge Preservation, Combining Bovine Xenograft with Collagen Matrix

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