Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide

Nai, Jijuan; Zhang, Chao; Shao, Huili; Li, Bingqian; Li, Huan; Gao, Lei; Dai, Mengmeng; Zhu, Lei; Hua-gang, Sheng

doi:10.1016/j.ijbiomac.2021.05.213

Cited by 155 publications

(66 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The monosaccharide composition is the most basic and important link in the structure analysis of polysaccharides, and due to the complexity of the structure, analysis of the monosaccharide composition of polysaccharides generally needs three steps: degradation of polysaccharides, structural modification of the monosaccharides, and their separation and detection. 12 In this study, S. chinensis polysaccharides were enriched by an optimized chemical technology, and the monosaccharides were obtained by acid hydrolysis, and, after derivatization, the monosaccharide composition of the polysaccharides was determined by HPLC-UV. Nine monosaccharide components were well separated; the contents of Man, GalA, Rha and Fuc in Chinese S. chinensis were higher than those in the Russian, while the contents of Glca, Glc, Gal, Xyl and Ara in Chinese S. chinensis were lower than those in the Russian.…”

Section: Resultsmentioning

confidence: 99%

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Han

Chen

Yuan

et al. 2022

Natural Product Communications

View full text Add to dashboard Cite

Schisandra chinensis Bail. polysaccharides from China (CSP) and Russia (RSP) were separated by DEAE-52 cellulose column chromatography. The content of neutral polysaccharide was determined by the phenol concentrated sulfuric acid method, the content of acid polysaccharide by the hydroxybiphenyl method, and the monosaccharide composition and molecular weight arrangement of CSP and RSP by 1-phenyl-3-methyl-5-pyrazolone (PMP) pre-column derivatization HPLC. The effects of CSP and RSP on the exercise endurance of mice were compared by the forelimb grip strength test, rota-rod test and weight-bearing swimming. The results showed that one neutral polysaccharide and three acidic polysaccharides could be eluted from a DEAE-52 cellulose column from CSP and RSP, respectively. The content of acidic and neutral polysaccharides in RSP was higher than that in CSP, and the anti-fatigue effect of RSP was more significant than that of CSP.

show abstract

Section: Resultsmentioning

confidence: 99%

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Han

Chen

Yuan

et al. 2022

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…Diels) is a Chinese herbal medicine traditionally used for replenishing blood. Studies have shown that Angelica sinensis polysaccharide significantly reduced the apoptosis rate of platelets and had an anti-apoptosis effect on cryopreserved platelet (Nai et al, 2021).…”

Section: Ethnic Herbal Medicine Used For Menstrual Disordersmentioning

confidence: 99%

Comparison of Herbal Medicines Used for Women’s Menstruation Diseases in Different Areas of the World

et al. 2022

View full text Add to dashboard Cite

Aims: This review aims to compare the use of herbal medicine used to treat women’s menstruation and the prevalence of menstrual diseases in different regions, which reveal the use of herbal medicine globally and provide scientific guidance for improving women’s health.Materials and Methods: The information available on herbal medicines for women between the years 2000 and 2021 was systematically collected via the library and electronic search systems such as Google Scholar, PubMed, ScienceDirect, and Web of Science as well as secondary resources including books and conference proceedings.Results: Totally, 571 ethnic medicines commonly used for women’s menstruation health in Asia, Europe, Oceania, Africa, and America were accounted. Zingiber officinale Roscoe (Ginger), Ruta graveolens L. (Common rue), Angelica sinensis (Oliv.) Diels (Angelica sinensis), Foeniculum vulgare Mill (Fennel), Catharanthus roseus (L.) G. Don (Catharanthus roseus) and other medicines which have obvious advantages and long-term usage are utilized in the treatment of menstrual diseases. Family Asteraceae, Lamiaceae, Apiaceae, Fabaceae, and Zingiberaceae are the most common medicinal plant families used for such treatments. In many instances, the application of fresh parts of plants was observed because of the healers’ belief regarding the higher efficiency of the medicine made from fresh plants. Edible plants are used in a wide range of countries.Conclusion: Women’s menstruation health is directly related to their health condition. Traditional medicines of most ethnic groups have contributed to women’s health care and treatment of gynecological diseases. Practitioners in this field have gained elaborate experience in treatments and medication, and assembled a large number of effective drugs and prescriptions. These experiences have also been inherited and developed by modern clinical application and scientific research. However, the basic research on these drugs is not sufficient, the knowledge of drug use has not been fully popularized, the advantages of drugs have not been fully utilized, and the guiding potential to modern drug research continues to be insufficient. As such, it is necessary to further promote and make a significant contribution to women’s health.

show abstract

“…The molecular weight is between 3.2 and 2252 kDa. ASP possesses multiple pharmacological activities, including anti-anaemia, liver protection, antidiabetic activity [ 55 ]. ASP [ 56 ] was modified with deoxycholic acid to fabricate amphiphilic conjugate (ASP-DOCA), which was synthesized following a one-step method [ 57 ].…”

Section: Targetingmentioning

confidence: 99%

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

Wang

Xiong

et al. 2022

Chin Med

View full text Add to dashboard Cite

Traditional Chinese medicine polysaccharides (TCMPs) are plentiful and renewable resources with properties such as biocompatibility, hydrophilicity, biodegradability, and low cytotoxicity. Because the polysaccharide molecular chain contains a variety of active groups, different polysaccharide derivatives can be easily produced through chemical modification. They have been increasingly used in drug delivery systems (DDS). However, the potential of polysaccharides is usually ignored due to their structural complexity, poor stability or ambiguity of mechanisms of actions. This review summarized the applications of TCMPs in DDS around four main aspects. The general characteristics of TCMPs as drug delivery carriers, as well as the relationships between structure and function of them were summarized. Meanwhile, the direction of preparing multifunctional drug delivery materials with synergistic effect by using TCMPs was discussed. This review aims to become a reference for further research of TCMPs and their derivatives, especially applications of them as carriers in pharmaceutical preparation industry.

show abstract

Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide

Cited by 155 publications

References 114 publications

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Comparison of Herbal Medicines Used for Women’s Menstruation Diseases in Different Areas of the World

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

Contact Info

Product

Resources

About