Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity

Abstract

Acetaminophen (APAP) is an analgesic and antipyretic agent primarily used in the clinical setting. However, high doses of APAP can cause oxidative stress. Guavas have been reported to provide anti‑inflammatory, anti‑microbial, anti‑oxidative and anti‑diarrheal functions. In addition, guavas have been reported to prevent renal damage due to progression of diabetes mellitus. Therefore, the aim of the present study was to investigate whether guavas can reduce APAP‑induced renal cell damage. In the present study, extracts from guavas were obtained and added to APAP‑treated renal tubular endothelial cells. The present results demonstrated that APAP induces cytotoxicity in renal tubular endothelial cells, while guava extracts inhibited this cytotoxicity. In addition, the study demonstrated that the protective effects of guava extracts against APAP‑induced cytotoxicity may be associated with inhibition of oxidative stress and caspase‑3 activation.

Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells

“…Guava extracts were prepared as described [1]. Briefly, extracts from the mature stage of the red guava fruit were used in this study.…”

“…Many studies have demonstrated that guava extracts have anti-inflammatory, anti-microbial, anti-oxidative and anti-cancer activities [1][2][3]. These functions of guava extracts are related to numerous bio-active molecules such as beta-caryophyllene oxide, vitamins, tannins, phenolic compounds, flavonoids and triterpenoid acids [2,[4][5][6].…”