Extraintestinal manifestations were common in children with coeliac disease and were more prevalent in patients with more severe clinical and histological presentation

Nurminen, Samuli; Kivelä, Laura; Huhtala, Heini; Kaukinen, Katri; Kurppa, Kalle

doi:10.1111/apa.14324

Cited by 37 publications

(42 citation statements)

References 31 publications

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“…The prevalence rates of the patients were different due to different age ranges and symptoms which were evaluated as EIM of the patients included in the study. However, some studies have reported that the prevalence of EIM in celiac patients is approximately 60% (12,13). In our study, we found the EIM prevalence in 87% of adult celiac patients.…”

Section: Discussionsupporting

confidence: 50%

“…Along with recent studies reported the prevalence of arthritis between 2-9%, in our study which arthralgia is added, joint involvement was found as 41.7% (12,13,25,26). In addition, the prevalence of oral involvement in studies is very contradictory, it has been reported in the range of 1-83% (13,26). It is thought that the different symptoms which were evaluated as oral involvement of the patients included in the study.…”

Section: Discussionsupporting

confidence: 47%

“…Therefore, it is reported that extra-intestinal manifestations (EIMs) may develop before the diagnosis of CD (11). Studies have shown that the prevalence of EIMs in celiac patients is around 60%, similar between pediatric and adult populations (12,13). Although it is known that CD is more common in women, it is seen that the data related to gender distribution of EIMs are contradictory (13).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that the prevalence of EIMs in celiac patients is around 60%, similar between pediatric and adult populations (12,13). Although it is known that CD is more common in women, it is seen that the data related to gender distribution of EIMs are contradictory (13). In addition, some EIMs recovered completely after early strict diet, while some of them recovered partially and somewhere not affected at all (12,13).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Extraintestinal Manifestations Associated with Celiac Disease

Kayar¹,

Dertli²,

Sürmeli³

et al. 2019

Eastern J Med

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Celiac disease (CD) can affect almost all organs of the body, including the nervous system, liver, skin, reproductive and musculoskeletal systems. In this study, it is aimed to determine the prevalence of extra-intestinal manifestations (EIMs) in adult celiac patients and to investigate the factors affecting the development of EIMs. The study included 230 celiac patients who were diagnosed and followed-up in our clinics between 2015-2019. The demographic and anthropometric characteristics, initial admissi on complaints, disease duration and dietary compliance of the patients were documented. All EIMs that accompanied the celiac disease were recorded, and their relationship with risk factors was analyzed. The age range of the patients was 18-72 years, and the mean age was 33.4±10.6 years. One hundred seventy two (74.8%) patients were female and disease follow-up was 4.8±3.5 years. The number of patients with accompanying EIMs was 202 (87.8%). Osteoporosis/osteopenia was found in 146(63.5%) patients, oral involvement in 116(50.4%) patients, arthritis/arthralgia in 96(41.7%) patients as the most common comorbidities. It was determined that, there was a significant relationship between EIM and body mass index. Although the EIMs development was less in patients wh o had strict diet; however, this was not statistically significant. The majority of adult celiac patients were found to be accompanied by EIMs. The diagnosis is delayed due to various clinical presentations. Lack of delay in diagnosis of celiac disease and consequently reduced gluten exposure seem to be the only factor in preventing some EIMs

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Section: Discussionsupporting

confidence: 50%