Extramedullary plasmacytoma

Alexiou, Christoph; Kau, R. J.; Dietzfelbinger, Hermann; Kremer, Marcus; Spiess, Jeffery; Schratzenstaller, Bruno; Arnold, W.

doi:10.1002/(sici)1097-0142(19990601)85:11<2305::aid-cncr2>3.0.co;2-3

Cited by 488 publications

(207 citation statements)

References 31 publications

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“…In der Giemsa-Färbung lässt sich die typische Radspeichenstruktur des Chromatins gut erkennen. [2,9,10]. Nach Möglichkeit sollten lokal begrenzte, primär extramedulläre Plasmozytome operativ im Gesunden entfernt werden.…”

Section: Fallunclassified

“…Da in ca. 25 % der Fälle mit einer Generalisierung der Erkrankung zu rechnen ist [2,9], müssen auch Patienten mit primär extramedullären Plasmozytomen lebenslang unter ärztlicher Kontrolle bleiben.…”

Section: Fallunclassified

“…Die extramedullären Plasmozytome gehören mit einer Inzidenz von 1/1000 000 zu den äußerst seltenen Tumoren und manifestieren sich überwiegend im oberen Aerodigestivtrakt [2] (l " Tab. 1).…”

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Dreifachmanifestation eines extramedullären Plasmozytoms im HNO-Bereich - Ein Fallbericht

Fischer¹,

Bärmann²,

Stasche³

2007

Laryngorhinootologie

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Plasmocytomas are non-Hodgkin's tumors which occur with an incidence of 4/100,000. Malignant plasma cells in bone marrow produce monoclonal antibodies which are typically found in urine and blood samples. In rare instances plasmocytoma occur exclusively in extramedullary locations preferring head and neck region. We report about two patients with extramedullary plasmocytoma, one of them with an extremely rare triple manifestation in the upper airway.

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Dreifachmanifestation eines extramedullären Plasmozytoms im HNO-Bereich - Ein Fallbericht

Fischer¹,

Bärmann²,

Stasche³

2007

Laryngorhinootologie

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“…Solitary plasmacytomas are rare tumors (Alexiou et al, 1999). They are classified as either solitary plasmacytomas of bone (SPB) or extramedullary plasmacytomas (EMP) of soft tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Majority of EMP's (about 80%) involve the upper air passage and are thought to arise in the submucosa. Other sites include lymph nodes, spleen, skin and subcutaneous tissues, gastrointestinal tract, thyroid and testes (Alexiou et al, 1999;Selby and Gore, 1995).…”

Section: Introductionmentioning

confidence: 99%

Extramedullary Pasmacytoma Masquerading as Chalazion

Maheshwari

2009

Orbit

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Extramedullary plasmacytoma (EMP) is a rare entity that belongs to the category of non-Hodgkin lymphoma. EMP make up 4% of all plasma cell tumors and occur mainly in the upper aerodigestive tract. Primary plasmacytoma involving the orbit is rare. There is a relation between solitary plasmacytoma and subsequent development of multiple myeloma. As no predictors of progression have been identified patients need indefinite follow-up. The authors report a case of EMP involving the eyelid in an otherwise healthy adult female.

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Radiotherapy vs Surgery for Survival and Locoregional Control of Head and Neck Extramedullary Plasmacytoma

Vasudevan,

Sayed,

Kapartiwar

et al. 2024

JAMA Otolaryngol Head Neck Surg

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ImportanceThere are significant gaps in the literature pertaining to the locoregional control and survival rates of extramedullary plasmacytoma (EMP) with respect to various treatment approaches.ObjectiveTo systematically evaluate the differences in radiotherapy and surgical outcomes in EMP.Data SourcesDatabases including PubMed, Scopus, Web of Science, Embase, and ScienceDirect were systematically searched from their inception up to November 2023.Study SelectionArticles reporting radiotherapy and surgical outcomes of head and neck EMP were included.Data Extraction and SynthesisA random-effects model for meta-analysis was used to obtain pooled estimates and calculate hazard ratios for survival and odds ratios for recurrence and progression of EMP.Main Outcomes and MeasuresSurvival, tumor control, and progression rates to multiple myeloma (MM) between radiation therapy and surgery for EMP of the head and neck.ResultsOf 742 included patients from 12 studies, 527 (71.0%) were male, and the median (IQR) age was 59.1 (53-62) years. A total of 505 patients (68.1%) received radiotherapy only, while 237 (31.9%) underwent surgery-only treatment for EMP. All included patients had an initial diagnosis of EMP without MM. Comparable trends were observed in overall survival and disease-free survival (DFS) rates at 2, 3, 5, and 10 years between patients with EMP treated with radiotherapy only and surgery only. Notably, there were no significant differences in recurrence rate (odds ratio, 0.65; 95% CI, 0.20-2.06) between radiotherapy-only and surgery-only treatment. However, radiotherapy-only treatment of EMP was associated with decreased odds of progression to MM compared with surgery (odds ratio, 0.4; 95% CI, 0.1-0.9). Sensitivity analysis revealed that the radiotherapy-only population had significantly better 5-year DFS (hazard ratio, 0.55; 95% CI, 0.31-0.96) compared with surgery-only treatment.Conclusions and RelevanceThis systematic review and meta-analysis provides evidence that patients with EMP receiving radiotherapy had significantly lower chances of progression to MM compared with surgery-only therapy. Additionally, radiotherapy had better 5-year DFS outcomes compared with surgery. Comparable outcomes in terms of overall survival rates, recurrence, and mortality rates were noted between radiotherapy-only and surgery-only EMP treatment groups.

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Extramedullary plasmacytoma

Cited by 488 publications

References 31 publications

Dreifachmanifestation eines extramedullären Plasmozytoms im HNO-Bereich - Ein Fallbericht

Dreifachmanifestation eines extramedullären Plasmozytoms im HNO-Bereich - Ein Fallbericht

Extramedullary Pasmacytoma Masquerading as Chalazion

Radiotherapy vs Surgery for Survival and Locoregional Control of Head and Neck Extramedullary Plasmacytoma

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