Extramedullary plasmocytoma: A rare malignancy in renal transplant recipient

Abstract

Available online xxxKeywords: Extramedullary plasmacytoma Post transplant lymphoproliferative disorder (PTLD) Autologous hematopoetic stem cell transplant (AHSCT) Renal transplant a b s t r a c t Extramedullary plasmacytoma in a post renal transplant recipient is an extremely rare type of post transplant lymphoproliferative disorder (PTLD) which warrants significant reduction in immunosuppressive therapy leading to increased risk of rejections and even graft loss. We describe a 49 year old male patient who after 14 years of renal transplant presented with extramedullary plasmacytomas in pancreas, gums, subcutaneous tissue and transplant kidney. He was treated with high dose melphalan followed by rescue autologous hematopoetic stem cell transplant and concurrent reduction in immunosuppression following which he achieved complete remission maintained on 5 years of follow up with astable allograft function. This case, to best of our knowledge is first case to be successfully managed with a rescue autologous hematopoetic stem cell transplant in a renal transplant patient with multifocal extramedullary plasmacytomas.

Fine‐needle aspiration cytology for the diagnosis of plasma cell neoplasms in the head and neck region: A systematic analysis of the literature

“…The electronic searches yielded 1143 articles (PubMed: 418, Web of Science: 292, Embase: 265, and Scopus: 168) and 82 studies reporting 102 individuals were included in this systematic review 17–98 (Figure 1).…”

“…Most cases were primary and extraosseous lesions. However, both extraosseous and intraosseous lesions result in a variety of findings, including swelling associated or not with pain, facial asymmetry, numbness, paraesthesia, and hoarseness 17–98 . Notably, the findings indicated that most cases had a diagnosis of plasmacytoma (extramedullary or solitary of bone) and the remaining ones had systemic involvement by PCM.…”

“…A recent systematic review identified concordance rates higher than 64% for the smear and 77% for the cell‐block technique regarding diagnostic capability for the evaluation of intraosseous jaw lesions, including malignant lesions 16 . Despite several published reports on the cytopathological diagnosis of PCN, either in isolated manifestations (extramedullary or solitary bone plasmacytoma) or as a consequence of PCM, 17–98 there is a lack of compiled information investigating the agreement of cytopathological and histopathological findings, along with others ancillary cytological methods such as smears and cell blocks. In fact, FNAC represents a faster, cheaper and more diversified noninvasive diagnostic approach.…”