Extranodal follicular dendritic cell sarcoma in mesentery: A case report

Abstract

Abstract. Extranodal follicular dendritic cell (FDC) sarcomas are not a common phenomenon. Due to the scarcity of the identified cases reported in the literature, FDC is probably under-recognized and commonly misdiagnosed. The diagnosis of FDC sarcomas is based on node-based spindle cell lesions, and the expression of CD21, CD35 and clusterin. The most commonly involved extranodal sites include the oral cavity, tonsil, gastrointestinal tract and liver. With the aid of immunohistochemical analysis and the two most reliable FDC markers, CD21 and CD35, the diagnostic accuracy has improved. When FDC sarcoma is suspected histologically, immunohistochemical stains for FDC differentiation should be performed to avoid potential misdiagnosis. This case report concerns the evaluation of a 43-year-old male Chinese patient with a large extranodal FDC sarcoma (20x18x9 cm) in the mesentery with elevated serum CA125 (76.9 U/ml). The diagnosis and treatment of this disease are also discussed.

Clinicopathological features of inflammatory pseudotumour‐like follicular dendritic cell tumour of the abdomen

“…In our series, two patients had elevated serum CA125 level that moderately decreased after tumour resection. The findings were similar to those in a previous report . This suggests that there is an intrinsic relationship between the serum CA125 level and inflammatory pseudotumour‐like FDC tumour.…”

“…The findings were similar to those in a previous report. 13 This suggests that there is an intrinsic relationship between the serum CA125 level and inflammatory pseudotumour-like FDC tumour. Elevated serum NSE levels were also observed in these two patients.…”

Follicular dendritic cell sarcoma of the spleen: A case report and review of the literature

“…The patient in the present study only presented with an abdominal mass and did not present with any other obvious symptoms. The manifestations of the patient are similar to the cases reported in the literature (9,10). Follicular dendritic cells are essential in the lymph nodes, where their primary role is directed towards antigen presentation and antigen-dependent B-cell maturation.…”

Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp

“…Furthermore, previously reported GI tumors involved the intestinal wall or mesentery, and were nearly all of the conventional type. The exception is a single case of IPT-like variant reported by Agaimy and Wünsch6 in which the main tumor was identified in the mesentery (6 cm) of the terminal ileum with a submucosal spreading (1.5 cm) 20. Interestingly, this tumor exhibited neoplastic cells with bizarre lobulated nuclei and prominent eosinophilia mimicking Hodgkin lymphoma.…”