Extranodal marginal zone B-cell lymphoma of the gastrointestinal tract sparing only the esophagus: A case report

Lin, Chung-Saint; Lai, Hui Chin; Tsai, M. F.; Chen, Tan-Hsia; Tseng, Szu-Wen; Chang, Han; Chen, Tzy-Yen

doi:10.4318/tjg.2012.0371

Cited by 3 publications

(2 citation statements)

References 9 publications

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“… 49 Single case reports of H pylori -negative ENMZL in the ileum and esophagus have also been documented. 50 , 51 Extranodal marginal zone B-cell lymphoma in the small intestine, known as immunoproliferative small intestinal disease (IPSID), is predominantly found in the Mediterranean and African regions, accounting for one third of the small intestinal lymphomas in these areas. 52 Two studies reported no association between IPSID and H pylori .…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature Review

Qureshi,

Patel,

Ajumobi

2024

Journal of Investigative Medicine High Impact Case Reports

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Extranodal marginal zone B-cell lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT), a rare subtype of B-cell lymphoma, is typically associated with Helicobacter pylori ( H pylori) infection, especially in gastric cases. However, this article presents 2 unique cases of H pylori-negative colonic ENMZL, challenging the conventional understanding of the disease. The first case involves an 80-year-old male diagnosed with Stage 1E ENMZL in the descending colon, and the second describes a 74-year-old male with sigmoid colon ENMZL. Both cases lacked H pylori infection, adding complexity to their management. Accompanying these case studies is a comprehensive literature review, delving into the epidemiology, pathology, clinical features, diagnosis, and treatment of H pylori-negative ENMZL, with a focus on gastrointestinal involvement. This review highlights the importance of considering H pylori-negative cases in ENMZL diagnosis and management, illustrating the need for further research and individualized treatment approaches in this uncommon lymphoma subtype.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature Review

Qureshi,

Patel,

Ajumobi

2024

Journal of Investigative Medicine High Impact Case Reports

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“…Patients with esophageal lymphoma may present with dysphagia (3), odynophagia (14) and weight loss (9). Additional clinical features include fever, night sweats (15), pharyngeal pain (16) and epigastric pain (17), and generalized weakness and dizziness (18) may also be present. Dysphagia symptoms are common due to the increased thickening of the esophageal wall.…”

Section: Discussionmentioning

confidence: 99%

Radiological and clinical features of primary NK/T-cell lymphoma involving the whole length of the esophagus: A case report

2017

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Primary esophageal natural killer (NK)/T-cell lymphoma is a markedly rare tumor. There were only 6 cases of the disease identified prior to June 2015. In the present study, the aforementioned cases were validated, and relevant computed tomography (CT) results and clinical features of primary esophageal NK/T-cell lymphoma were determined, to increase awareness of this type of tumor. CT features and clinical presentations of a patient with pathologically confirmed esophageal NK/T-cell lymphoma was analyzed. The patient exhibited non-specific clinical symptoms and CT images revealed diffuse thickening of the entire length of the esophagus. The patient received cycles of systemic chemotherapy and subsequent chest CT images demonstrated prompt and marked shrinkage of the tumor. At the time of writing, the patient has survived for 24 months and experiences a good quality of life without postprandial fullness or difficulty swallowing solid food. In addition, the characteristics of 6 patients with complete clinical features of this type of tumor, on the basis of a review of published studies (online PubMed, Medline, Google Scholar, Chinese Biomedicine Database and China Journal Full Text Database search), were retrospectively analyzed. Although primary esophageal NK/T-cell lymphoma is a markedly rare tumor, it is considered to be included in differential diagnosis of patients presenting with a fungal or viral infection, therapy-related mucositis or reflux esophagitis. The final diagnosis of primary esophageal NK/T-cell lymphoma is on the basis of a combination of clinical, CT and histopathological results.

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Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

Al-Maghrabi

2023

Gastroenterology Research and Practice

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Background. Primary esophageal lymphoma (PEL) is a rare disorder. The objective of this study was to document the clinicopathological features of PEL at two tertiary hospitals in the western region of the Kingdom of Saudi Arabia. Methods. All PELs diagnosed between May 2002 and June 2022 were retrieved. Histopathological and immunohistochemical slides were reviewed. Additional immunohistochemistry stains were performed in selected cases. Follow-up data were collected. Results. There were only eight cases of PEL in the records of the two hospitals. The age of the patients ranged between 50 and 74 years (median 62 years and mean 62.5 years). There were six males (80%) and two females (20%). None of the patients were immunocompromised or had human immunodeficiency virus (HIV) infection. The clinical manifestation included dysphagia and loss of weight. Six cases were diffuse large B-cell lymphoma (DLBCL), and two were low-grade mucosa-associated lymphoid tissue lymphoma. Conclusion. PEL is an extremely rare disease with male predominance. DLBCL is the most common pathological type in our community. There was no relation to immune status or HIV infection in this series. Clinical presentations were typically dysphagia with weight loss. Further reporting of PEL cases might help explain this disease and improve its diagnosis and management.

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Extranodal marginal zone B-cell lymphoma of the gastrointestinal tract sparing only the esophagus: A case report

Cited by 3 publications

References 9 publications

H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature Review

H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature Review

Radiological and clinical features of primary NK/T-cell lymphoma involving the whole length of the esophagus: A case report

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia

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