Extranodal Marginal Zone Lymphoma Occurring along the Trachea and Central Airway

Kang, Ji Young; Park, Hyun Jin; Lee, Kyo‐Young; Lee, Sook Young; Kim, Seung Joon; Park, Sung Hak; Kim, Young Kyoon

doi:10.3349/ymj.2008.49.5.860

Cited by 20 publications

(20 citation statements)

References 17 publications

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“…However our patient presented with the lesions localized from the trachea to the left main bronchus. This case has characteristics in common with the case reported by Kang et al [5], whose case showed multiple, variable-sized nodules causing bronchial narrowing from the proximal trachea to bronchi of both lungs, including the carina. The lesions of both of these cases are systemic disseminated.…”

Section: Discussionsupporting

confidence: 84%

Tracheal stenting for primary tracheal mucosa-associated lymphoid tissue lymphoma

2013

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Primary tracheal mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare. We report a 49-year-old female patient with the complaint of dyspnea. Fiberoptic bronchoscopy showed polypoid, variable-sized and irregular nodules causing narrowing of the tracheal lumen from the proximal trachea to the left main bronchus. Because of severe stenosis in the airway and the severity of symptoms, this case was unresectable. The patient was then treated successfully with placement of an endobronchial stent through bronchofibroscopy. After the placement of the stent, bronchoscopic biopsy was performed. Pathological analysis confirms a diagnosis of MALT-associated malignant lymphoma. We performed systemic chemotherapy on the patient. The temporary stent was removed after the reduction of the stenosis. This is the first case in which tracheal MALT lymphoma was treated successfully following tracheal stent insertion guided by bronchofibroscopy. Temporary tracheal stenting can be a favorable choice for a patient with tracheal stenosis caused by primary tracheal MALT lymphoma.

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Section: Discussionsupporting

confidence: 84%

Tracheal stenting for primary tracheal mucosa-associated lymphoid tissue lymphoma

2013

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“…There are other previous case reports which have shown female predominancy (18, 20). All patients were female in our series.…”

Section: Discussionmentioning

confidence: 81%

“…There is one case report in the literature that describes diffuse narrowing of the tracheobronchial tree with endobronchial nodularities of extranodal marginal zone lymphoma, occurring along the trachea and central airway (20). However, to the best of our knowledge, BALT lymphoma manifesting as diffuse wall thickening in the central airway on CT has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Primary Endobronchial Marginal Zone B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue: CT Findings in 7 Patients

et al. 2013

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ObjectiveTo investigate CT and 18F-flurodeoxyglucose (18F-FDG) positron-emission tomography/CT findings of primary endobronchial marginal zone B-cell lymphoma of the bronchus-associated lymphoid tissue (BALT).Materials and MethodsFrom June 2006 through April 2012, seven patients (six female, one male; age range, 21-61 years; mean age, 49 years) were examined who were pathologically diagnosed with the primary endobronchial marginal zone B-cell lymphoma of BALT. We evaluated the locations and characteristics of the lesions on CT and 18F-FDG-PET/CT scans. The lesions were classified into the following three patterns: 1) solitary intraluminal nodule; 2) several tiny nodular protrusions; and 3) diffuse wall thickening.ResultsA solitary intraluminal nodule was observed in four patients (57.1%), several tiny nodular protrusion in two patients (28.6%), and diffuse wall thickening in one patient (14.3%). The lesions were categorized into 3 major locations: confined to the trachea (n = 3), confined to the lobar bronchus (n = 2), and diffuse involvement of the trachea and both main bronchi (n = 2). All lesions demonstrated homogeneous iso-attenuation as compared with muscle on pre- and post-enhancement scans. Secondary findings in the lungs (n = 3; 42.9%) included postobstructive lobar atelectasis (n = 1), air trapping (n = 1), and pneumonia (n = 1). On 18F-FDG-PET/CT (n = 5), 4 lesions showed homogeneous uptake with maximum standardized uptake values (mSUV), ranging 2.3-5.7 (mean mSUV: 3.3). One lesion showed little FDG uptake.ConclusionPrimary endobronchial marginal zone B-cell lymphoma of the BALT manifests as three distinct patterns on CT, with the solitary intraluminal nodule presenting as the main pattern. Most lesions demonstrate homogeneous but weak FDG uptake on 18F-FDG-PET/CT.

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“…Both primary and secondary tracheobronchial disease most commonly manifest as a soft-tissue nodular or polypoid mass (Fig 10a). Diffuse polypoid or broad-based lesions are seen in a minority of cases (Figs 8, 10b) (2,37,38). Postobstructive atelectasis or consolidation may be present where there is significant airway narrowing (Fig 10b).…”

Section: Ct Findingsmentioning

confidence: 99%

Spectrum of CT Findings in Thoracic Extranodal Non-Hodgkin Lymphoma

et al. 2017

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Non-Hodgkin lymphoma (NHL) frequently manifests in extranodal structures in the chest, often in the form of secondary involvement but occasionally as primary disease. Because staging and treatment are affected by the presence of extranodal disease at imaging, radiologists' interpretation and management of suspicious findings are critical to patient care. Unfortunately, owing to considerable imaging overlap with other diseases, primary extranodal lymphoma is difficult to diagnose with imaging alone. Radiologists should have a heightened degree of suspicion in patients at risk (including patients with immune compromise, autoimmune diseases, or a history of stem cell or solid organ transplant) or with particular imaging appearances (including the vertebral wraparound sign, nonresolving consolidation, an infiltrative soft-tissue mass, and lesions demonstrating vascular encasement without invasion). For patients with known NHL, positron emission tomography/computed tomography (PET/CT) using fluorine 18 (F)-labeled fluorodeoxyglucose (FDG) is now preferred for routine staging in most cases. CT remains heavily used, and identification of subtle extranodal involvement with CT can be improved with use of intravenous contrast material and careful review of multiplanar images. Pericardial effusion, pleural soft tissue (even when mild), mass-like consolidation, perilymphatic nodularity, and new lytic bone lesions are particularly suggestive of secondary involvement in a patient with known NHL. Magnetic resonance imaging is a helpful problem-solving tool when equivocal findings would change staging and treatment. This comprehensive review illustrates the spectrum of CT manifestations of extranodal NHL in the chest, including the pleura, lung, airways, heart, pericardium, esophagus, chest wall, and breast. RSNA, 2017.

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Extranodal Marginal Zone Lymphoma Occurring along the Trachea and Central Airway

Cited by 20 publications

References 17 publications

Tracheal stenting for primary tracheal mucosa-associated lymphoid tissue lymphoma

Tracheal stenting for primary tracheal mucosa-associated lymphoid tissue lymphoma

Primary Endobronchial Marginal Zone B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue: CT Findings in 7 Patients

Spectrum of CT Findings in Thoracic Extranodal Non-Hodgkin Lymphoma

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