Extraosseous Ewing sarcoma with foci of neuroblastoma-like differentiation associated with EWSR1(Ewing sarcoma breakpoint region 1)/FLI1 translocation without prior chemotherapy

Vali, Kaveh; Kokta, Victor; Beaunoyer, Mona; Fetni, Raouf; Teira, Pierre; Sartelet, Hervé

doi:10.1016/j.humpath.2012.03.006

Cited by 8 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive expression of CD56 was found in three cases in our results. However, the variable positive expression rate of CD56 in ES could be as high as 40% or negative expression according to different studies, 9,54 suggesting that it is not applicable as a diagnostic marker of EWS/pPNET.…”

Section: Discussionmentioning

confidence: 99%

Meningeal Ewing Sarcoma/Peripheral PNET: Clinicopathological, Immunohistochemical and FISH study of four cases

Duan

Yang

et al. 2016

Neuropathology

View full text Add to dashboard Cite

Meningeal Ewing Sarcoma (ES)/peripheral primitive neuroectodermal tumor (pPNET) is a rare diagnostically challenging small round cell tumor in the CNS. This study investigates the clinical pathological features of four cases of this tumor from archives of 6 years in our hospital. Patients were within the median age of 21.5 years and male to female ratio was 1:1. The tumors distributed at the supra-tentorial location, posterior fossa and lumbar vertebral canal, usually presenting as the dura-sited nodule or having close connection with the meninges within the cranium or vertebral canal. Histopathologically, small round undifferentiated tumor cells with hypercellularities, scant cytoplasm and inconspicuous nucleoli were observed, although some components such as atypical larger vesicular nuclei, prominent nucleoli of tumor cells, necrotic foci and mesenchymal collagen proliferation forming the lobular structure, were also appreciated. Immunohistochemally, tumor cells displayed membranous positivity of CD99 (4/4), nuclear positivity of FLI-1 (4/4) and NKX2.2 (4/4), negativity of EMA, GFAP and synaptophysin expression. The histochemical PAS staining showed weak positivity in one case. Fluorescence in situ hybridization (FISH) test using EWSR1 (22q12) dual color break apart rearrangement probe showed positive results in two cases. Results suggest that using a panel of immunohistochemical markers, including NKX2.2, CD99, FLI-1, EMA, GFAP and synaptophysin, combined with the supplementary EWSR1 FISH test, helps to define the diagnosis of meningeal ES/pPNET of CNS.

show abstract

Section: Discussionmentioning

confidence: 99%

Meningeal Ewing Sarcoma/Peripheral PNET: Clinicopathological, Immunohistochemical and FISH study of four cases

Duan

Yang

et al. 2016

Neuropathology

View full text Add to dashboard Cite

show abstract

“…One consideration in the pathogenesis of this unusual pathological picture is the possibility of a primary neuroblastoma or PNET/Ewing sarcoma that has undergone neural-like differentiation secondary to chemotherapy following metastasis to a cervical lymph node. [ 11 12 13 ] However, the primary tumor lacked expression of neural markers or CD99 except for S-100 protein. The significance of S-100 protein expression is unknown; staining for S-100 protein is recognized to be nonspecific and may be observed in a variety of tumors of neuroectodermal origin.…”

Section: Discussionmentioning

confidence: 99%

Cervical ganglioneuroma in collision with a metastatic undifferentiated carcinoma

Jabbour¹,

Zaatari²,

Salem³

et al. 2015

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Cervical ganglioneuromas are extremely rare with approximately six case reports. The current report highlights a unique collision tumor between a cervical ganglioneuroma and a metastatic undifferentiated carcinoma arising from a primary gingival mass. A 53-year-old male presented with a 2 cm left gingival mass that was excised and treated with systemic chemotherapy. Consequently, 9 months later, he developed a 3.2 cm left submandibular mass followed by recurrence of the left gingival mass. From the clinicopathologic perspective, this had to be separated from the differentials: ganglioneuroblastoma or metastatic involvement of a lymph node from primary gingival undifferentiated carcinoma.

show abstract

Atypical growth on MRI in a case of Ewing’s sarcoma despite lower SUV on PET

et al. 2013

View full text Add to dashboard Cite

Ewing's sarcoma is a rare primary bone malignancy of small round blue cells. Treatment typically consists of neoadjuvant chemotherapy, surgical resection, and adjuvant chemotherapy. The disease response to chemotherapy can be followed with fluorodeoxyglucose (FDG) positron emission tomography (PET), which measures the metabolic activity of the tumor, and by magnetic resonance imaging (MRI), which measures tumor size. We present a unique case in which the tumor grew in size following neoadjuvant chemotherapy but decreased in metabolic activity, making it difficult to judge efficacy of the chemotherapy. An atypical response to chemotherapy in this case caused tumor growth due to a fibrotic reaction while viable tumor cells were eradicated. This case highlights the ability of FDG-PET scan to identify the uncommon situation in which a tumor that increased in size may have had a favorable response to chemotherapy. This possibility should be considered in similar cases in which FDG-PET scan shows diminishing metabolic activity despite tumor growth.

show abstract

Extraosseous Ewing sarcoma with foci of neuroblastoma-like differentiation associated with EWSR1(Ewing sarcoma breakpoint region 1)/FLI1 translocation without prior chemotherapy

Cited by 8 publications

References 12 publications

Meningeal Ewing Sarcoma/Peripheral PNET: Clinicopathological, Immunohistochemical and FISH study of four cases

Meningeal Ewing Sarcoma/Peripheral PNET: Clinicopathological, Immunohistochemical and FISH study of four cases

Cervical ganglioneuroma in collision with a metastatic undifferentiated carcinoma

Atypical growth on MRI in a case of Ewing’s sarcoma despite lower SUV on PET

Contact Info

Product

Resources

About