Extrapulmonary oat-cell carcinoma presenting as a primary left ventricular tumor: A case report

Khouzam, Rami N.; Fernández, José J.; Ramírez, Santiago R.; González, José J. Salazar; Sethi, Gulshan K.

doi:10.1067/mhl.2002.124008

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Small cell carcinoma presenting as a cardiac mass has only been described in a handful of case studies [ 1 – 3 , 15 ] with the majority documenting a primary pulmonary lesion. An extrapulmonary small cell carcinoma of cardiac origin would be incredibly rare, with only one potential case ever reported in the literature [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma presenting as a biatrial mass with obstructive physiology: a case report

2021

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Background Small cell carcinoma is a highly aggressive and often fatal cancer that most commonly arises in the lung, although it can occasionally arise from other sites, such as the gastrointestinal tract, prostate or cervix. Cardiac involvement, however, is extremely uncommon and therefore has been poorly documented in the literature. Case presentation We describe a rare case of a 31-year-old male with small cell carcinoma presenting as a massive, 15-cm cardiac tumor invading the bilateral atria, interatrial septum, and pericardium without an apparent primary malignancy on PET CT and cardiac MRI. With extensive tissue necrosis, traditional methods of obtaining a right atrial endomyocardial biopsy via internal jugular venous access failed and a diagnosis was made via endoscopic ultrasound guided transesophageal fine needle aspiration of the left atrial mass. Due to the extensive tumor invasion, the patient was not a suitable candidate for surgical resection, debulking, or heart transplant. The patient was treated with etoposide, carboplatin, atezolizumab, and radiation therapy with initial monitoring in the intensive care unit due to concern that tumor lysis may cause rapid cardiac decompensation. Unfortunately, 4 months after chemoradiation therapy, the malignancy progressed and the patient passed away 6 months after the initial diagnosis. Conclusion We describe a rare occurrence of small cell carcinoma presenting as a massive cardiac tumor without apparent primary malignancy. This case demonstrates useful alternative diagnostic strategies and treatment considerations for patients presenting with a rare cardiac mass.

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Section: Discussionmentioning

confidence: 99%

Small cell carcinoma presenting as a biatrial mass with obstructive physiology: a case report

2021

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“…2 Seventy-five percent of primary cardiac tumors are benign, primarily atrial myxomas, the remaining 25% are malignant, most frequently sarcomas. 3 Until now, only tumors of the central nervous system have not been demonstrated to develop cardiac metastases. 4 Heart is an unusual site for metastases because of the relative avascularity of the endocardium, the vigorous kneading action of the myocardium, the rapid blood flow through the heart and the paucity of lymphatic communications between the heart and surrounding tissues.…”

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confidence: 99%

Detection of an Asymptomatic Right-Ventricle Cardiac Metastasis from a Small-Cell Lung Cancer by F-18-FDG PET/CT

Orcurto

Delaloye

Letovanec

et al. 2009

Journal of Thoracic Oncology

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A right heart metastasis of a small-cell lung cancer was found on the whole-body F-fluoro-deoxy-glucose positron emission tomography/computed tomography (F-FDG-PET/CT) of a 69-year-old smoker investigated for a right pulmonary mass discovered on chest radiography after a fracture of the right humerus. The PET scan showed an increased FDG uptake by the mass in the right lung and an intense, atypical focal activity of the right ventricle strongly suggestive of a neoplastic process. CT-guided lung biopsy revealed a small-cell lung cancer and myocardial biopsy confirmed the presence of a cardiac metastasis. The patient was treated with six cycles of chemotherapy followed by radiation therapy, which included the heart lesion. At follow-up PET/CT 2 months after the end of treatment, the abnormal cardiac uptake had disappeared, whereas increased FDG uptake persisted in the pulmonary residual mass.

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Extrapulmonary oat-cell carcinoma presenting as a primary left ventricular tumor: A case report

Cited by 2 publications

References 9 publications

Small cell carcinoma presenting as a biatrial mass with obstructive physiology: a case report

Small cell carcinoma presenting as a biatrial mass with obstructive physiology: a case report

Detection of an Asymptomatic Right-Ventricle Cardiac Metastasis from a Small-Cell Lung Cancer by F-18-FDG PET/CT

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