Extrarenal Erythropoietin

Naughton, Brian A.; Gordon, Albert S.; Piliero, Sam J.; Liu, Philip L.‐F.

doi:10.1007/978-1-4612-6301-2_32

Cited by 9 publications

(21 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neither Ep nor HEF is present in significant quantities in either normal human plasma or plasma from renoprival patients with essentially nor mal livers. This is consistent with previous observations that the presence of regener ative foci in the liver, such as appear after hepx or toxic liver injury, is a prerequisite to the production of HEF [Naughton et al, 1978;L/'wet al, 1980]. The absence of renal Ep and the uremia noted in these patients both contribute to the severe degree of anemia which is observed (B: 4, 5) [Raich and Korst, 1978].…”

Section: Discussionsupporting

confidence: 80%

“…In general, these materials dis played negligible levels of Ep and HEF activity as did plasma from anephric pa tients with essentially normal livers (B: 4, 5). Ep values in the plasma of two glomer ulonephritis patients varied, as did their hematocrits (C: 6, 7), although HEF-in- [Naughton et al, 1978, Mean serum Ep levels observed in the serum of various experimental ani mals are: unoperated hypoxic 1.28-1.43; anephric (6 h post-surgery), 0.05; nephrectomy and 6 h of hy poxia (0.4 atm), 0.07-0.12; hepx (72 h post-surgery), nephrectomy, and hypoxia 0.69-0.91 [Naughton et al, 1977], 4 p values were obtained using the Student's t test. Group A (1 -3) are considered as control and levels of significance were determined by comparison to group A; NS = not significant.…”

Section: Resultsmentioning

confidence: 99%

“…The rats were exsanguinated via the abdominal aorta and serum from each group was pooled and assayed for Ep in exhypoxic polycythemic mice as described previously. Stimulation of hepatic Ep levels in reci pient rats when compared to controls is an indication of the presence of HEF in the donor plasma sample [Naughton et al, 1978]. Plasma from each donor was injected into three separate groups, each consisting of 4-6 recipients.…”

Section: Hef Assaymentioning

confidence: 99%

“…When serum was taken from either the hepatic vein or abdominal aorta of rats at 48-96 h after hepx and in jected into normal rats 18 h prior to neph rectomy and exposure to hypoxia, hepatic Ep levels in these recipients were signifi cantly higher than in those receiving ser um from sham hepx rats [Naughton et al, 1978]. This action was attributed to a spe cific substance in the donor serum, termed the hepatic erythropoietic factor (HEF).…”

mentioning

confidence: 99%

“…Under this scheme, hepatic Ep production will increase when the level of HEF exceeds that of RIF. HEF levels are elevated in animals with liver regenerating after partial surgical removal [Naughton et al, 1978] or hepatotoxic injury [Liu et al, 1980], Removal of the kidneys from these animals causes a further augmentation of HEF levels due to the elimination of the RIF. The following experiments were un dertaken to determine if a similar renalhepatic antagonism to hepatic Ep elabora tion is present in humans.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Evidence for an Erythropoietin-Stimulating Factor in Patients with Renal and Hepatic Disease

Naughton¹,

Liu²,

Naughton³

et al. 1983

Acta Haematol

Self Cite

View full text Add to dashboard Cite

Recently, a factor was discovered in the serum of hepatectomized animals which was capable of augmenting the hepatic erythropoietin response to hypoxia when injected into normal rats. This substance was localized in the liver via an in situ perfusion technique and was termed the hepatic erythropoietic factor (HEF). Patients with kidney disease, liver disease, and combined renal and hepatic disease were studied in this report. Detectable HEF levels were found in the plasma of patients with both liver and kidney disease and were highest in anephric patients with various liver diseases. However, HEF levels were negligible in normal humans or in patients manifesting renal disease with no hepatic involvement. The data suggest that HEF-induced hepatic erythropoietin synthesis may occur in humans as well as in animals.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Hef Assaymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Evidence for an Erythropoietin-Stimulating Factor in Patients with Renal and Hepatic Disease

Naughton¹,

Liu²,

Naughton³

et al. 1983

Acta Haematol

Self Cite

View full text Add to dashboard Cite

show abstract

The regenerating liver: A site of erythropoiesis in the adult long‐evans rat

et al. 1979

View full text Add to dashboard Cite

Erythropoiesis, which is primarily hepatic in the rat during fetal and early neonatal life, shifts almost entirely to the bone marrow in the neonatal-adolescent stage of development. In the adult, extramedullary erythropoiesis has been demonstrated in the liver and spleen under certain pathological conditions when bone marrow red cell production is insufficient. In the present study, erythropoietic foci have been found in young-adult rat liver regenerating 24-72 hr after subtotal hepatectomy. This erythropoiesis is both extravascular and sinusoidal, with some erythroblastic islands noted. The centrolobular hepatic area contains the highest concentration of erythroblasts. Peripheral blood reticulocytosis coincides with the appearance of these cells and this is considered as an indicator of effective erythropoiesis. Liver regenerating after partial hepatectomy produces significant quantities of erythropoietin (Ep) in response to hypoxia. Subtotal hepatectomy may confer upon the adult liver the ability to revert to a fetal-like condition both in its ability to produce Ep and to function as a hematopoietic inductive microenvironment for erythropoiesis.

show abstract

Reticuloendothelial system (RES) hyperfunction and erythropoietin (Ep) production in the regenerating liver

Naughton

Birnbach

Liu

et al. 1979

Journal of Surgical Oncology

View full text Add to dashboard Cite

Hepatic cells in rats were evaluated after subtotal hepatectomy using scintillation scanning with technetium sulfur colloid (TSC), autoradiography, and microstereology techniques. The ability of the liver to accumulate TSC increased during the course of the regeneration as did the labeling of Kupffer and parenchymal cells with tritiated thymidine (3H-tdR). Kupffer to parenchymal cell number ratios and Kupffer cell relative areas were also elevated, attaining peak values at 72 hours post-hepatectomy. This period corresponds to the time of peak erythropoietin (Ep) production in rats with regenerating livers after nephrectomy and exposure to hypoxia. These findings suggest that the Kupffer cell may function as a cellular site of Ep formation.

show abstract

Extrarenal Erythropoietin

Cited by 9 publications

References 65 publications

Evidence for an Erythropoietin-Stimulating Factor in Patients with Renal and Hepatic Disease

Evidence for an Erythropoietin-Stimulating Factor in Patients with Renal and Hepatic Disease

The regenerating liver: A site of erythropoiesis in the adult long‐evans rat

Reticuloendothelial system (RES) hyperfunction and erythropoietin (Ep) production in the regenerating liver

Contact Info

Product

Resources

About