Extraskeletal myxoid chondrosarcoma: a case report with fine needle aspiration (FNA) cytology

Gonidi, Maria; Athanassiadou, Pauline; Petrakakou, E.; Zerva, Cherry; Dimou, Sofia

doi:10.1111/j.1365-2303.1997.tb00596.x

Cited by 9 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 After excluding cases of skeletal chondrosarcoma involving soft tissue, we found 29 cases describing the cytopathology of EMC in the English literature (Table 3). [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Series containing 5 cases, 21 4 cases, 23 3 cases, 16 and 2 cases 24 have been reported. All remaining examples are single-case reports.…”

Section: Resultsmentioning

confidence: 99%

Cytopathology of extraskeletal myxoid chondrosarcoma

Jakowski

Wakely

2007

Cancer

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Cytopathology of extraskeletal myxoid chondrosarcoma

Jakowski

Wakely

2007

Cancer

View full text Add to dashboard Cite

“…13 Cytologic descriptions largely have been restricted to individual case reports. [21][22][23][24] Despite the name, myxoid chondrosarcoma rarely reveals hyaline cartilage differentiation. On conventional cytologic smears, the tumor is comprised of fragments of myxoid stroma tinctorially similar to that observed in myxoid liposarcoma.…”

Section: Discussionmentioning

confidence: 99%

The value of fine-needle aspiration biopsy in the differential diagnosis of adult myxoid sarcoma

Kilpatrick

Ward

Bos

2000

Cancer

View full text Add to dashboard Cite

“…Histologically, EMC presents as a multinodular neoplasm composed of cords and delicate strands of small, uniform cells dispersed in a copious chondromyxoid matrix. Greater cellularity is observed in the periphery of the lobules . Rare cases show cellular smears composed of medium sized atypical plasmocytoid cells with prominent nucleoli .…”

Section: Introductionmentioning

confidence: 98%

Fine‐needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features

Santos¹,

Martins

Lemos³

2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

Background Extraskeletal myxoid chondrosarcoma (EMC) is a tumor of uncertain differentiation. Few data are available regarding its cytomorphological features in fine‐needle aspiration (FNA). Specific cytogenetic alterations involving the NR4A3 gene are found in EMC and can be identified in FNA samples. Methods We retrospectively reviewed 14 FNAs performed in 11 patients with an EMC; 10 FNAs were performed preoperatively on primary tumors; 2 were performed on recurrences and 2 were performed on metastasis. Cytological features were compared with histological findings. Immunohistochemistry (IHC) and molecular studies were performed both in FNA and histological specimens. Results A preoperative cytological diagnosis of EMC was rendered in eight FNAs performed in newly diagnosed tumors and in recurrent/metastatic cases. A descriptive diagnosis of a myxoid neoplasm was made in the remaining two cases. Smears were moderately hypercellular, composed of plasmocytoid to fusiform cells, with scant, pale cytoplasm, bland nuclei and inconspicuous nucleoli, dispersed as cords, strands and occasionally with a lace‐like pattern, in an abundant chondromyxoid matrix. IHC performed showed focal positivity for S100 and NSE. Fluorescence in situ hybridization technique performed in three FNA specimens showed EWSR1 gene rearrangements in all, concomitant with NR4A3 gene rearrangement in one case. Histological specimens showed typical features of EMC and NR4A3 gene rearrangements were found in all cases tested. Conclusion FNA cytology is a reliable method to perform a preoperative diagnosis of EMC regarding its cytomorphological and molecular features. Main differential diagnoses include myoepithelial tumors of soft tissue, myxoid liposarcoma and myxofibrosarcoma. Ancillary studies are helpful when coupled with cytomorphology evaluation.

show abstract

Extraskeletal myxoid chondrosarcoma: a case report with fine needle aspiration (FNA) cytology

Cited by 9 publications

References 5 publications

Cytopathology of extraskeletal myxoid chondrosarcoma

Cytopathology of extraskeletal myxoid chondrosarcoma

The value of fine-needle aspiration biopsy in the differential diagnosis of adult myxoid sarcoma

Fine‐needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features

Contact Info

Product

Resources

About