Extreme Prostate-Specific Antigen Response to Infusional 5-Flourouracil in Castrate-Resistant Prostate Cancer

Abstract

Prostate cancer that has progressed after androgen deprivation, abiraterone, and taxane therapy is challenging to treat successfully. Herein we report a dramatic response to continuous-infusion 5-fluorouracil (5-FU) at a dose of 200 mg/m in a patient with rapidly progressive, heavily pretreated, metastatic castrate-resistant prostate cancer. Baseline prostate-specific antigen values declined from 1,890 ng/mL to <1 ng/mL after 5-FU therapy. We hypothesized that prostate-specific membrane antigen overexpression may result in cancer cells uniquely susceptible to antifolate therapies.

Repurposing Alone and in Combination of the Antiviral Saquinavir with 5-Fluorouracil in Prostate and Lung Cancer Cells

“…This drug has shown the ability to radiosensitize prostate cancer cells before [ 25 ]. Furthermore, 5-FU is a drug that is potentiated when there is a reduction of folates, and prostate cancer cells overexpress a prostate-specific membrane antigen (PSMA), which is a folate hydrolase [ 26 ]. These two indications made us choose 5-FU as a reference cancer drug to test in this study, and even if we did not obtain an IC 50 , significant cytotoxicity to prostate cancer cells was observed, which prompted us to continue using this drug in the combination studies.…”

Role of Nanotrace Element in Prostate Cancer an Update

“…The effects of cisplatin and docetaxel were studied in biomechanical and morphological characteristics of prostate cancer cells .It shows the more stiffness in cisplatin and docetaxel cells also reduce the motility [56]. antineoplastic responses [57]. Prostate cancer treatment has been improved after androgen deprivation, abiraterone, and taxane therapy and it became successful.…”

“…Chemotherapy for prostate cancer 5-fluorouracil: It is an analog of pyrimidine which stop the DNA synthesis during the S Phase and stop the thymidylate synthetase. In this 124 patient under taken the 5-fluorouracil with varying doses and it exhibit 9%antineoplastic responses[57]. Prostate cancer treatment has been improved after androgen deprivation, abiraterone, and taxane therapy and it became successful.…”