Extremely Increased Serum Carbohydrate Antigen 19-9 Levels Caused by New or Resistant Infections to Previous Antibiotics in Chronic Lung Diseases

Shin, Ji Young; Yoo, Su Jin; Park, Bo Mi; Jung, Sung Soo; Kim, Ju Ock; Lee, Jeong Eun

doi:10.4046/trd.2013.75.3.125

Cited by 12 publications

(15 citation statements)

References 9 publications

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“…The correlation between CA19-9, CA72-4, and TNM stage in LAC and LSCC were similar to that of CEA; the correlation coefficients were lower. CA19-9 increased in patients with infectious lung disease [23]. NSCLC, especially advanced NSCLC, was often accompanied by severe infection.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

2018

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Background The correlation between tumor markers (TM) and TNM stage of non-small-cell lung cancer (NSCLC) has not been widely reported. Methods TM levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma (LSCC), and 103 cases of benign chest disease (BCD) were analyzed before treatment. Results By Kendall's tau-b correlation analysis, CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag were correlated with T stage of LAC (r = 0.235, p < 0.05; r = 0.298, p < 0.05; r = 0.254, p < 0.05; r = 0.063, p < 0.05; r = 0.080, p < 0.05; r = 0.268, p < 0.05; and r = 0.080, p < 0.05). CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with N stage of LAC (r = 0.356, p < 0.05; r = 0.415, p < 0.05; r = 0.340, p < 0.05; r = 0.117, p < 0.05; r = 0.175, p < 0.05; and r = 0.351, p < 0.05). CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with M stage of LAC (r = 0.365, p < 0.05; r = 0.353, p < 0.05; r = 0.293, p < 0.05; r = 0.135, p < 0.05; r = 0.169, p < 0.05; and r = 0.312, p < 0.05). CA125, CYFRA21-1, and SCC-Ag were correlated with T stage of LSCC (r = 0.202, p < 0.05; r = 0.233, p < 0.05; and r = 0.099, p < 0.05). CA125 and CYFRA21-1 were correlated with N stage of LSCC (r = 0.178, p < 0.05 and r = 0.284, p < 0.05). CA125, CA15-3, and CYFRA21-1 were correlated with M stage of LSCC (r = 0.214, p < 0.05; r = 0.152, p < 0.05; and r = 0.213, p < 0.05). Combining hazard ratio, AUC, sensitivity, specificity, NPV, and PPV, it was concluded that CEA and CYFRA21-1were the most related TM of LAC. SCC-Ag and CYFRA21-1 were the most related TM of LSCC. Conclusions CEA combined with CYFRA21-1 contributed to auxiliary diagnosis of LAC. CYFRA21-1 combined with SCC-Ag contributed to auxiliary diagnosis of LSCC. CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with primary tissue and metastasis of LAC. CA125 and CYFRA21-1 were correlated with primary tissue and metastasis of LSCC.

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Section: Discussionmentioning

confidence: 99%

Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

2018

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“…CA 19-9 levels were also found to be increased in other biliary tract-related diseases such as cholecystitis, cholangitis, choledocholithiasis, primary biliary cirrhosis, viral hepatitis, and pancreatitis (9,(14)(15)(16)(17)(18)(19). High levels of CA 19-9 have also been reported in the case reports of respiratory, rheumatologic, renal, and infectious diseases (20)(21)(22).…”

Section: Baseline Characteristics Of the Study Populationmentioning

confidence: 82%

Erken akut pankreatitte karbonhidrat antijen 19-9 seviyeleri

Binicier

Paköz

2019

Akademik Gastroenteroloji Dergisi

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For the cases of acute pancreatitis, it is crucial to determine the etiology to regulate the treatment and determine the need for endoscopic retrograde cholangiopancreatography (ERCP). Until now, there has been not a single laboratory test to distinguish between stasis-induced mechanical (biliary) pancreatitis and nonmechanical (nonbiliary) pancreatitis. There are so many developed scoring systems, which are not easy to use in the routine clinical practice because they are complicated and include many

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“…In addition, in the patients with malignant tumors such as stomach, ovary, hepatocellular and colorectal carcinomas and in benign cases (pancreatitis, cholangitis, and choledocholithiasis) involving the biliary tree have been shown to increase levels [8][9][10][11] . There have also been case reports that found elevated CA 19-9 levels may be seen in cases of tuberculosis, infections, various rheumatological, and benign renal events [12][13][14][15] .…”

Section: Baseline Characteristics Of the Study Populationmentioning

confidence: 99%

CA 19-9 levels in patients with acute pancreatitis due to gallstone and metabolic/toxic reasons

Binicier

Paköz

2019

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE Acute pancreatitis (AP) is an important clinical event with an increased frequency due to increased life expectancy, obesity, and alcohol use. There are some data about the elevation of carbohydrate antigen (CA) 19-9 levels in benign and malignant pancreaticobiliary events in the literature, but in AP they are limited. The aim of this study was to evaluate the CA 19-9 level in patients with AP and determine its relationship according to the cause. METHODS Between 2010-2018, 173 patients evaluated with CA 19-9 levels as well as by standard laboratory tests were included in the study. CA 1 9-9 levels and laboratory findings were compared in patients with pancreatitis due to gallstone (group 1) and metabolic/toxic reasons such as hyperlipidemia, alcohol, or drug use (group 2). RESULTS There were 114 (66%) patients in the group 1 and 59 (34%) patients in the group 2. The majority of patients with high CA 19-9 level were in group 1 (92.1% vs 6.8%). CA 19-9 level, as well as amylase, lipase, AST, ALT and bilirubin levels were found to be statistically higher in patients with AP due to gallstone compared to patients with metabolic/toxic AP. CONCLUSIONS Patients with AP due to gallstone, were found to have a high level of CA 19-9 at admission. Early stage CA 19-9 levels may contribute to standard laboratory tests in the etiology of the disease in patients diagnosed with AP.

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Extremely Increased Serum Carbohydrate Antigen 19-9 Levels Caused by New or Resistant Infections to Previous Antibiotics in Chronic Lung Diseases

Cited by 12 publications

References 9 publications

Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

Erken akut pankreatitte karbonhidrat antijen 19-9 seviyeleri

CA 19-9 levels in patients with acute pancreatitis due to gallstone and metabolic/toxic reasons

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