Eye diseases burden in China in the past 30 years

Chen, Binbin; Lou, Lixia; Ye, Juan

doi:10.3724/zdxbyxb-2021-0246

Cited by 3 publications

(1 citation statement)

References 78 publications

(116 reference statements)

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“…It has become a major public health problem worldwide [ 1 ]. Vision assumes more than 70% of the external information and is an important sensory organ to maintain the high quality of human life [ 2 ]. Retinopathy with progressive and irreversible visual loss or severe visual impairment exists in all age groups.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review

Yang

Zhao

et al. 2022

Molecules

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Vascular retinopathy is a pathological change in the retina caused by ocular or systemic vascular diseases that can lead to blurred vision and the risk of blindness. Lycium barbarum polysaccharides (LBPs) are extracted from the fruit of traditional Chinese medicine, L. barbarum. They have strong biological activities, including immune regulation, antioxidation, and neuroprotection, and have been shown to improve vision in numerous studies. At present, there is no systematic literature review of LBPs on vascular retinal prevention and treatment. We review the structural characterization and extraction methods of LBPs, focus on the mechanism and pharmacokinetics of LBPs in improving vascular retinopathy, and discuss the future clinical application and lack of work. LBPs are involved in the regulation of VEGF, Rho/ROCK, PI3K/Akt/mTOR, Nrf2/HO-1, AGEs/RAGE signaling pathways, which can alleviate the occurrence and development of vascular retinal diseases in an inflammatory response, oxidative stress, apoptosis, autophagy, and neuroprotection. LBPs are mainly absorbed by the small intestine and stomach and excreted through urine and feces. Their low bioavailability in vivo has led to the development of novel dosage forms, including multicompartment delivery systems and scaffolds. Data from the literature confirm the medicinal potential of LBPs as a new direction for the prevention and complementary treatment of vascular retinopathy.

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Section: Introductionmentioning

confidence: 99%