Eye movement abnormalities in essential tremor versus tremor dominant Parkinson’s disease

Visser, Femke; Bour, L.J.; Lee, Y.X.; Brinke, Timo R. ten; Rootselaar, A.F. van

doi:10.1016/j.clinph.2019.01.026

Cited by 16 publications

(16 citation statements)

References 51 publications

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“…CI confidence interval, HC healthy control group, PD group with Parkinson's disease, (m) mixed task design with prosaccades and antisaccades, SD standard deviation, Std. standardized ◂ (Briand et al, 1999), B14 (Bonnet et al, 2014b), B19 (Barbosa et al, 2019), C12 (Cameron et al, 2012), C00 (Crevits et al, 2000), E17 (Ewenczyk et al, 2017), G16 (Gorges et al, 2016), H10 (Harsay et al, 2010), H19 (Hanuška et al, 2019), L19 (Lu et al, 2019), L90 (Lueck et al, 1990), L16 (Lemos et al, 2016), M05 (Mosimann et al, 2005), N16 (Nemanich & Earhart, 2016), N19 (Nagai et al, 2019), R17 (Ranchet et al, 2017), RP15 (Rivaud-Péchoux et al, 2007), V19 (Visser et al, 2019), vK09 (van Koningsbruggen et al, 2009, W15 (Walton et al, 2015), W16 (Wang et al, 2016), W19 (Waldthaler et al, 2019a)…”

Section: Moderator Analysismentioning

confidence: 99%

Antisaccades in Parkinson’s Disease: A Meta-Analysis

et al. 2021

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The usefulness of eye-tracking tasks as potential biomarkers for motor or cognitive disease burden in Parkinson’s disease (PD) has been subject of debate for many years. Several studies suggest that the performance in the antisaccade task may be altered in patients with PD and associated with motor disease severity or executive dysfunction. In this meta-analysis, random effects models were used to synthesize the existing evidence on antisaccade error rates and latency in PD. Furthermore, meta-regressions were performed to assess the role of motor and cognitive disease severity, dopaminergic medication and methodological factors. Additionally, the impact of acute levodopa administration and activation of deep brain stimulation was evaluated in two separate sub-analyses.This meta-analysis confirms that antisaccade latency and error rate are significantly increased in PD. Disease duration, Unified Parkinson’s disease rating scale score and Hoehn and Yahr stage mediate the effect of PD on antisaccade latency with higher motor burden being associated with increased antisaccade latency.Acute administration of levodopa had no significant effects on antisaccade performance in a small number of eligible studies. Deep brain stimulation in the subthalamic nucleus, on the other hand, may alter the speed accuracy trade-off supporting an increase of impulsivity following deep brain stimulation in PD.According to the results of the meta-analysis, antisaccade latency may provide a potential marker for disease severity and progression in PD which needs further confirmation in longitudinal studies.

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Section: Moderator Analysismentioning

confidence: 99%

Antisaccades in Parkinson’s Disease: A Meta-Analysis

et al. 2021

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“…In the past few years, advanced studies conducted using modern genetic and neuroimaging methods, such as functional magnetic resonance imaging (fMRI) have indicated that human cerebellum also sustains autonomic, limbic, and cognitive functions, including language and thinking; hence, this brain region was lately associated with the occurrence and development of autism . On the basis of the data collected by genetic testing and/or using MRI methods, other reports also relate cerebellar dysfunctions to Alzheimer disease (AD), attention‐deficit/hyperactivity disorder, Huntington disease, hereditary ataxia, and Parkinson disease (PD) . In the case of PD, it was considered that the pathological changes in the cerebellum might be induced by dopaminergic degeneration, which may account for some clinical symptoms specific to this neurodegenerative disorder, while in the case of AD, it recently discovered a unique motif of the cerebellar cortex associated to the disease …”

Section: Introductionmentioning

confidence: 99%

Orbitrap mass spectrometry for monitoring the ganglioside pattern in human cerebellum development and aging

et al. 2020

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We have developed here a superior approach based on high-resolution (HR) mass spectrometry (MS) for monitoring the changes occurring with development and aging in the composition and structure of cerebellar gangliosidome. The experiments were focused on the comparative screening and structural analysis of gangliosides expressed in fetal and aged cerebellum by Orbitrap MS with nanoelectrospray ionization (nanoESI) in the negative ion mode. The employed ultrahigh-resolution MS platform allowed the discrimination, without the need of previous separation, of 159 ions corresponding to 120 distinct species in the native ganglioside mixtures from fetal and aged cerebellar biopsies, many more than detected before, when MS platforms of lower resolution were employed. A number of gangliosides, in particular polysialylated belonging to GT, GQ, GP, and GS classes, modified by O-fucosylation, O-acetylation, or CH 3 COO − were discovered here, for the first time in human cerebellum. These components, found differently expressed in fetal and aged tissues, indicated that the ganglioside profile in cerebellum is development stage-and agespecific. Following the fragmentation analysis by high-energy collision-induced dissociation (HCD) tandem MS (MS/MS), we have also observed that the intimate structure of certain compounds has not changed during the development and aging of the brain, an aspect which could open new directions in the investigation of ganglioside biomarkers in cerebellar tissue.

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“…VGSs are often measured for the differential diagnosis of neurodegenerative parkinsonism [3][4][5][6]33]. In PD, VGS gain may reflect the dopaminergic depletion in the striatum.…”

Section: Discussionmentioning

confidence: 99%

“…VGSs are classified as reflexive saccades and easily evoked even in dementia individuals compared with more complex saccades, such as antisaccades (saccades directed contralaterally to visual stimuli) or memory-guided saccades (saccades to re-Eur Neurol 2021;84:110-118 DOI: 10.1159/000514246 membered locations). Measurements of these reflexive and complex saccades are useful in the differential diagnosis of neurodegenerative parkinsonian syndromes [3][4][5][6]. In individuals with Parkinson's disease (PD), memory-guided saccades usually demonstrate evident abnormalities closely related to nigrostriatal degeneration [5,6]; in contrast, VGSs are normal or exhibit subtle abnormalities [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Measurements of these reflexive and complex saccades are useful in the differential diagnosis of neurodegenerative parkinsonian syndromes [3-6]. In individuals with Parkinson’s disease (PD), memory-guided saccades usually demonstrate evident abnormalities closely related to nigrostriatal degeneration [5, 6]; in contrast, VGSs are normal or exhibit subtle abnormalities [3-6].…”

Section: Introductionmentioning

confidence: 99%

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The Association of Visually Guided Saccades and DAT-SPECT Findings in Parkinson’s Disease

Kobayashi

Kuwabara

2021

Eur Neurol

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Background: In individuals with Parkinson’s disease (PD), visually guided saccades (VGSs) reportedly reflect general motor dysfunction and cognitive impairments. However, it has not been fully elucidated whether the VGS abnormalities result from nigrostriatal degeneration or other PD-related neural changes. Methods: We measured VGS latency and gain in 50 PD participants and 56 age-matched normal controls (NCs), and PD participants underwent dopamine transporter (DAT) single-photon emission computed tomography (SPECT) within 2 months of the measurement. VGSs were evoked by a white dot on a monitor, which was presented at the center and pseudo-randomly jumped off horizontally (10° or 20° eccentricity) or vertically (10° or 15°). First, we compared the parameters between PD participants and NCs for each target location. Second, in the participants who exhibited striatal DAT asymmetry on SPECT, VGSs contralaterally directed to the more severely affected striatum were compared with those ipsilaterally directed. Third, effects of the DAT-SPECT specific binding ratio (SBR) on VGSs were analyzed. Results: PD participants demonstrated prolonged latencies when the target was presented at the upward 15° eccentricity and decreased gains at all target locations. Contralateral VGSs relative to the side of the more severely affected striatum were more delayed and hypometric than ipsilateral. The SBR had a significant positive effect on VGS gain. Conclusions: In participants with PD, saccadic abnormalities were emphasized when VGSs were directed contralaterally to the more severely affected striatum. Moreover, the dopaminergic nigrostriatal degeneration on DAT-SPECT was mainly associated with VGS gain.

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Eye movement abnormalities in essential tremor versus tremor dominant Parkinson’s disease

Cited by 16 publications

References 51 publications

Antisaccades in Parkinson’s Disease: A Meta-Analysis

Antisaccades in Parkinson’s Disease: A Meta-Analysis

Orbitrap mass spectrometry for monitoring the ganglioside pattern in human cerebellum development and aging

The Association of Visually Guided Saccades and DAT-SPECT Findings in Parkinson’s Disease

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