Eye movement desensitization and reprocessing therapy in subsyndromal bipolar patients with a history of traumatic events: A randomized, controlled pilot-study

Navarro, Patricia Novo; Landín-Romero, Ramón; Raduà, Joaquim; Viçens, Víctor; Fernández, Isabel; García, Francisca; Pomarol‐Clotet, Edith; McKenna, Peter J.; Shapiro, Francine; Amann, Benedikt L.

doi:10.1016/j.psychres.2014.05.012

Cited by 76 publications

(51 citation statements)

References 35 publications

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“…Evidence-based therapeutic interventions to eliminate subsyndromal symptoms are obviously needed. So far, only preliminary supportive data exist for lamotrigine, lithium [45], and adjunctive psychological interventions to pharmacological treatment [46,47]. …”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of the Risk of Subsequent Mood Episodes in Bipolar Disorder

Raduà

Grunze

Amann

2017

Psychother Psychosom

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Background: Reported relapse and recurrence rates in bipolar disorder (BD) differ significantly between studies. Most data originate from highly selective patients participating in sponsored randomized controlled trials with narrow inclusion criteria. To estimate the true risk of a subsequent mood episode (SME) under real-world conditions, we conducted a meta-analysis of rates of SME as reported in naturalistic BD studies. Methods: PubMed, ScienceDirect, Scopus, and Web of Knowledge were searched until July 2015. Studies reporting the time until the emergence of an SME, from which individual data or Kaplan-Meier plots with censors marked could be retrieved, were included. Results: Twelve studies comprising 5,837 patients met the inclusion criteria. The median time to an SME in adults after an index episode was 1.44 years. The risk of an SME was 44% during the first year. Not having a SME during this first year lowered this risk to 19% in the second year. The risk was higher in bipolar II disorder (BD-II) than in bipolar I disorder (BD-I; HR = 1.5). In BD-I, the risk of a subsequent manic, mixed, or depressive mood episode was higher after an index episode of the same polarity (HR = 1.89-5.14). The overall risk of an SME was higher in patients with persisting subsyndromal symptoms (HR = 2.17). Conclusions: The data from this study provide a more reliable estimate of the risk of an SME in BD in real-world settings. Further research into the longitudinal course of BD-II is warranted to confirm its role as a risk factor for SME.

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Section: Discussionmentioning

confidence: 99%

Meta-Analysis of the Risk of Subsequent Mood Episodes in Bipolar Disorder

Raduà

Grunze

Amann

2017

Psychother Psychosom

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“…This study adds to a small, but growing body of literature that indicates EMDR has potential to treat depression (Bae et al ., 2008; Grey, 2011; Hofmann et al ., 2014) and symptoms of depression and hypomania in bipolar patients (Novo et al ., 2014). It also shows that EMDR does not necessarily need to be an adjunct to another therapy but can be used as the standard protocol describes (Shapiro, 2001).…”

Section: Discussionmentioning

confidence: 99%

EMDR as a treatment for long‐term depression: A feasibility study

2017

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ObjectiveCurrent treatments for long‐term depression – medication and psychotherapy – are effective for some but not all clients. New approaches need to be developed to complement the ones already available. This study was designed to test the feasibility of using an effective post‐traumatic stress disorder treatment for people with long‐term depression.DesignA single‐case experimental design with replications was undertaken as a feasibility study of eye movement desensitization and reprocessing (EMDR) in treating long‐term depression.MethodsThirteen people with recurrent and/or long‐term depression were recruited from primary care mental health services and given standard protocol EMDR for a maximum of 20 sessions. Levels of depression were measured before and after treatment and at follow‐up, clients also rated their mood each day.ResultsEight people engaged with the treatment; seven of these had clinically significant and statistically reliable improvement on the Hamilton Rating Scale for Depression. Daily mood ratings were highly variable both during baseline and intervention.Conclusions EMDR is a feasible treatment for recurrent and/or long‐term depression. Research on treatment efficacy and effectiveness is now required.Practitioner points EMDR may be an effective treatment for depression. EMDR could be considered if first‐line approaches (CBT and counselling) have been tried and failed. EMDR may be particularly helpful for service users with a history of trauma.

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“…So far, treatment options in this population are scarce. However, a recent randomized controlled trial found beneficial effects of Eye Movement Desensitization Reprocessing Therapy on mood and trauma symptoms in sub-syndromal bipolar patients with a history of traumatic life events (Novo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%