Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia

Wong, Oscar W H; Chan, Anne; Wong, Adrian; Lau, CK; Yeung, Jonas; Mok, Vincent; Lam, Linda C.W.; Chan, Sandra Sau Man

doi:10.1016/j.parkreldis.2018.03.013

Cited by 21 publications

(11 citation statements)

References 25 publications

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“…Compared to the left hemisphere, the correlations between verb and letter fluency were more robust in the right hemisphere. The temporal lobe is considered the center of verbal recognition memory; furthermore, semantic verbal fluency task is more sensitive to assess temporal region impairments (Henry and Crawford, 2004 ; Clark et al, 2014 ; Wong et al, 2018 ). Previous findings indicate that the VPC task is specifically more sensitive to assess medial temporal lobe (MTL) dysfunction in patients with MCI (Clark et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Mild Cognitive Impairment Based on Eye Movement Parameters in an Aging Chinese Population

Nie

Qiu

Phillips

et al. 2020

Front. Aging Neurosci.

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Background: The pathogenesis of dementia often starts several years prior to clinical onset during which the individual is asymptomatic. Existing strategies for the accurate diagnosis of early dementia are limited by high cost and the invasive nature of the procedures. Eye movement parameters associated with cognitive functions may be helpful in the early identification of dementia and in the development and evaluation of preventive and therapeutic strategies. Objective: We aimed to assess differences in eye movement parameters between healthy elderly individuals and patients with mild cognitive impairment (MCI). Furthermore, we examined the correlations between eye movement parameters with cognitive functions and specific hemispheric region and neural structures in individuals with MCI. Method: Eighty individuals with MCI without dementia (based on DSM-IV criteria) identified by community screening and 170 healthy controls were administered Chinese versions of MoCA and NTB, and a long (20 min) or short (5 min) version of a visual paired comparison (VPC) task. Two weeks later, 44 MCI patients and 107 healthy controls completed a retest of the VPC task, 44 MCI patients and 43 healthy controls among them administered a MRI. At the end of 1-year follow-up, a subset of 26 individuals with MCI and 57 healthy controls were administered the long version of VPC task and MoCA test again. Eye movement parameters and the relationship of eye movement parameters with cognitive functions and with changes in neural structures were compared between groups. Results: Patients with MCI were older, had less education, and had lower scores on cognitive tests than healthy controls. After adjustment for age and level of education, patients with MCI had lower novelty preference scores on the VPC than healthy controls. Using the logistic regression model, the amount of time that subjects focused on these novel images could predict MCI patients from normal elderly with an out of sample area

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Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Mild Cognitive Impairment Based on Eye Movement Parameters in an Aging Chinese Population

Nie

Qiu

Phillips

et al. 2020

Front. Aging Neurosci.

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“…As in other neurodegenerative diseases, ET-based cognitive studies are overlooked in PD, with few cognitive domains being explored using these methods. In the memory domain, smooth pursuit has been explored as well as saccades and fixations, showing impairments in different levels (Crutcher et al, 2009;Fukushima et al, 2015;Fukushima et al, 2017;Wong et al, 2018). Executive functions such as attention (Norton et al, 2016) and inhibitory control (Wang et al, 2016;Ranchet et al, 2017;Turner et al, 2017) were studied using measures including pupil response, fixations and saccades and using different tasks such as the prosaccade and antisaccade tasks, as well as object tracking.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Eye tracking – The overlooked method to measure cognition in neurodegeneration?

2019

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Cognitive screening ET tests have been developed for this condition [40]. Smooth pursuit and saccades have been shown to be impaired in Parkinson's disease (PD) patients depending on the severity [41]. The authors noted that ET studies can often take away the confounding motor skill impairment that traditional psychometric tests have difficulty in avoiding.…”

Section: Eye Tracking Examinations and Other Neurodegenerative Diseasementioning

confidence: 99%

The Role of Eye Tracking Technology in Assessing Older Driver Safety

Carr

Grover

2020

Geriatrics

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A growing body of literature is focused on the use of eye tracking (ET) technology to understand the association between objective visual parameters and higher order brain processes such as cognition. One of the settings where this principle has found practical utility is in the area of driving safety. Methods: We reviewed the literature to identify the changes in ET parameters with older adults and neurodegenerative disease. Results: This narrative review provides a brief overview of oculomotor system anatomy and physiology, defines common eye movements and tracking variables that are typically studied, explains the most common methods of eye tracking measurements during driving in simulation and in naturalistic settings, and examines the association of impairment in ET parameters with advanced age and neurodegenerative disease. Conclusion: ET technology is becoming less expensive, more portable, easier to use, and readily applicable in a variety of clinical settings. Older adults and especially those with neurodegenerative disease may have impairments in visual search parameters, placing them at risk for motor vehicle crashes. Advanced driver assessment systems are becoming more ubiquitous in newer cars and may significantly reduce crashes related to impaired visual search, distraction, and/or fatigue.

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Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia

Cited by 21 publications

References 25 publications

Early Diagnosis of Mild Cognitive Impairment Based on Eye Movement Parameters in an Aging Chinese Population

Early Diagnosis of Mild Cognitive Impairment Based on Eye Movement Parameters in an Aging Chinese Population

Eye tracking – The overlooked method to measure cognition in neurodegeneration?

The Role of Eye Tracking Technology in Assessing Older Driver Safety

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