The study determined the best fit model for the resistance to change among tertiary teachers in the Davao Region based on organizational communication, work ethic, and self-efficacy. The structural equation model (SEM) was employed in a stratified, random technique with a sample of 400 teachers where 50% were from Davao del Sur 15% from both Davao de Oro and Davao del Norte 10% from both Davao Oriental and Davao Occidental. For content validity and reliability, personal and online surveys were collected from modified survey questionnaires. A quantitative descriptive and causal method of research was used. The findings of the study on resistance to change with mean, standard deviation, Pearson product-moment correlation, linear regression, and SEM as statistical tools revealed the following: the level of organizational communication was very high; the level of work ethic was very high; the level of self-efficacy was very high; and, the level of resistance to change of the tertiary teachers was very high. Moreover, a significant relationship existed between these variables; thus, organizational communication, work ethic, and self-efficacy significantly influence resistance to change. Of the five (5) generated models, Model 5 best fits resistance to change, where self-efficacy is the most significant indicator of resistance to change. The model successfully passed all the conventions of a reasonable fit; hence, it is deemed the most parsimonious model.