F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in
            <i>Arabidopsis thaliana</i>

Nelson, David C.; Scaffidi, Adrian; Dun, Elizabeth A.; Waters, Mark T.; Flematti, Gavin R.; Dixon, Kingsley W.; Beveridge, Christine A.; Ghisalberti, Emilio L.; Smith, Steven M.

doi:10.1073/pnas.1100987108

Cited by 404 publications

(438 citation statements)

References 56 publications

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“…In addition, strigolactones and analogous chemicals (i.e., karrikins) regulate seed germination as part of a light-dependent process (Tsuchiya et al 2010;Nelson et al 2011). Because of their role in plant growth and development, strigolactones are considered an additional class of hormones besides the already well-established hormone groups.…”

Section: Introductionmentioning

confidence: 99%

Strigolactones fine-tune the root system

Rasmussen

Depuydt

Goormachtig

et al. 2013

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Strigolactones were originally discovered to be involved in parasitic weed germination, in mycorrhizal association and in the control of shoot architecture. Despite their clear role in rhizosphere signaling, comparatively less attention has been given to the belowground function of strigolactones on plant development. However, research has revealed that strigolactones play a key role in the regulation of the root system including adventitious roots, primary root length, lateral roots, root hairs and nodulation. Here, we review the recent progress regarding strigolactone regulation of the root system and the antagonism and interplay with other hormones

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Section: Introductionmentioning

confidence: 99%

Strigolactones fine-tune the root system

Rasmussen

Depuydt

Goormachtig

et al. 2013

Planta

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“…Perception of and signaling by karrikins, compounds originally identified in the smoke of forest fires, are also associated with D3 and KAI2, an α/β hydrolase that is highly homologous to D14 [18]. Recent studies have identified the putative transcriptional repressor D53 [19,20] as well as the transcription factor BES1 as SCF D3 substrate targets in response to SL exposure and the D53 paralog SMAX1 in response to karrikin exposure.…”

Section: Introductionmentioning

confidence: 99%

Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3

et al. 2015

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Strigolactones (SLs) are endogenous hormones and exuded signaling molecules in plant responses to low levels of mineral nutrients. Key mediators of the SL signaling pathway in rice include the α/β-fold hydrolase DWARF 14 (D14) and the F-box component DWARF 3 (D3) of the ubiquitin ligase SCF D3 that mediate ligand-dependent degradation of downstream signaling repressors. One perplexing feature is that D14 not only functions as the SL receptor but is also an active enzyme that slowly hydrolyzes diverse natural and synthetic SLs including GR24, preventing the crystallization of a binary complex of D14 with an intact SL as well as the ternary D14/SL/D3 complex. Here we overcome these barriers to derive a structural model of D14 bound to intact GR24 and identify the interface that is required for GR24-mediated D14-D3 interaction. The mode of GR24-mediated signaling, including ligand recognition, hydrolysis by D14, and ligand-mediated D14-D3 interaction, is conserved in structurally diverse SLs. More importantly, D14 is destabilized upon the binding of ligands and D3, thus revealing an unusual mechanism of SL recognition and signaling, in which the hormone, the receptor, and the downstream effectors are systematically destabilized during the signal transduction process.

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“…The d3/max2/rms4 mutants are also SL insensitive 1,2 . D3/ MAX2/RMS4 genes encode members of the F-box-family protein [17][18][19][20] that participate in an Skp-cullin-F box (SCF) complex 18 and have diverse roles in the plant lifecycle 14,[21][22][23][24][25][26][27][28][29][30] . Recently, it has been reported that petunia DAD2, an orthologue of rice DWARF14 (D14) protein, can hydrolyse the enol ether linkage of GR24 and interacts with PhMAX2A, a petunia orthologue of Arabidopsis MAX2 protein, indicating that the formation of the DAD2-PhMAX2A complex initiates an SCF-mediated signal transduction pathway 31 .…”

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confidence: 99%

Molecular mechanism of strigolactone perception by DWARF14

et al. 2013

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Strigolactones (SLs) are phytohormones that inhibit shoot branching and function in the rhizospheric communication with symbiotic fungi and parasitic weeds. An a/b-hydrolase protein, DWARF14 (D14), has been recognized to be an essential component of plant SL signalling, although its precise function remains unknown. Here we present the SL-dependent interaction of D14 with a gibberellin signalling repressor SLR1 and a possible mechanism of phytohormone perception in D14-mediated SL signalling. D14 functions as a cleavage enzyme of SLs, and the cleavage reaction induces the interaction with SLR1. The crystal structure of D14 shows that 5-hydroxy-3-methylbutenolide (D-OH), which is a reaction product of SLs, is trapped in the catalytic cavity of D14 to form an altered surface. The D14 residues recognizing D-OH are critical for the SL-dependent D14 À SLR1 interaction. These results provide new insight into crosstalk between gibberellin and SL signalling pathways.

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F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in Arabidopsis thaliana

Cited by 404 publications

References 56 publications

Strigolactones fine-tune the root system

Strigolactones fine-tune the root system

Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3

Molecular mechanism of strigolactone perception by DWARF14

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