F,N-Doped carbon dots as efficient Type I photosensitizers for photodynamic therapy

Wu, Xiaoyan; Xu, Mingsheng; Wang, Shuna; Abbas, Khurram; Huang, Xin; Zhang, Renquan; Tedesco, Antônio Cláudio; Hong, Bo

doi:10.1039/d1dt03788a

Cited by 56 publications

(41 citation statements)

References 50 publications

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“…The peaks displayed in the region of 2850–2950 cm −1 were ascribed to the typical sp 3 C-H stretching vibrations [ 44 ]. The peaks located at 1735, 1616, and 1404 cm −1 were related to the stretching vibrations of COOH, C=O, and C-N, respectively [ 40 , 45 ]. Moreover, the characteristic absorption peak of the C-F bond, together with the C=C stretching vibration, was observed at 1274 and 1175 cm −1 [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…The peaks located at 1735, 1616, and 1404 cm −1 were related to the stretching vibrations of COOH, C=O, and C-N, respectively [ 40 , 45 ]. Moreover, the characteristic absorption peak of the C-F bond, together with the C=C stretching vibration, was observed at 1274 and 1175 cm −1 [ 40 ]. Thus, the as-prepared NFCDs possessed different functional groups, such as the hydroxyl, carboxyl, and amide groups, which are attributed to the fluorescence of the NFCDs [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Apart from this, the splitting of the N1s peak in Figure 2 d indicates the presence of pyridinic N (399.25 eV) and graphitic N (401.24 eV) [ 49 , 50 ]. Lastly, the F1s spectra displayed a single characteristic peak at 687.09 eV, assigned to the covalent C-F, respectively [ 40 ]. Thus, the XPS results of all the existing functional groups demonstrated a close match with the FT-IR analysis, confirming the presence of common luminescent centers [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, it has been demonstrated that the dopant atoms on the surface functional groups affect the electronic transition significantly, indicating a promising strategy for preparing nanomaterials with specific or tunable fluorescence emissions [ 38 ]. Among all the commonly used elements for doping, the introduction of F presents the electron-withdrawing effects and strong hydrogen bonding interactions, which would change the surface charge, tune the emission fluorescence and thus improve the detection capacities [ 39 , 40 , 41 , 42 ]. In our previous work, N-doped DL-malic acid-derived CDs were synthesized with blue fluorescence and a QY of 9.8% [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

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One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection

et al. 2022

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Carbon dots (CDs) have caught enormous attention owing to their distinctive properties, such as their high water solubility, tunable optical properties, and easy surface modification, which can be generally used for the detection of heavy metals and organic pollutants. Herein, nitrogen and fluorine co-doped carbon dots (NFCDs) were designed via a rapid, low-cost, and one-step microwave-assisted technique using DL-malic acid and levofloxacin. The NFCDs emitted intense green fluorescence under UV lighting, and the optical emission peak at 490 nm was observed upon a 280 nm excitation, with a high quantum yield of 21.03%. Interestingly, the spectral measurements illustrated excitation-independent and concentration-independent single-color fluorescence owing to the presence of nitrogen and fluorine elements in the surface functional groups. Additionally, the NFCDs were applied for the selective detection of Fe3+ and ascorbic acid based on the “turn-off” mode. The detection limits were determined as 1.03 and 4.22 µM, respectively. The quenching mechanisms were explored using the static quenching mechanism and the inner filter effect. Therefore, a NFCDs fluorescent probe with single color emission was successfully developed for the convenient and rapid detection of Fe3+ and ascorbic acid in environments.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection

et al. 2022

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“…Selenium doped CDs were shown to selectively bind to RNA and damage the nuclear membrane by ROS generation ( Xu et al, 2020 ). There are ample reports in literature suggesting the doping of CD with heteroatoms or metals such as N, P ( Zhao et al, 2019 ), Cu ( Wang et al, 2019 ), S ( Li et al, 2020b ), F/N ( Wu et al, 2022 ), Hf ( Su et al, 2020b ), Sn ( Hu et al, 2021 ) with enhanced bioimaging and PDT applications.…”

Section: Quantum Dots As Photosensitizers In Pdtmentioning

confidence: 99%

Semiconductor quantum dots for photodynamic therapy: Recent advances

Uprety

Abrahamse

2022

Front. Chem.

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Photodynamic therapy is a promising cancer treatment that induces apoptosis as a result of the interactions between light and a photosensitizing drug. Lately, the emergence of biocompatible nanoparticles has revolutionized the prospects of photodynamic therapy (PDT) in clinical trials. Consequently, a lot of research is now being focused on developing non-toxic, biocompatible nanoparticle-based photosensitizers for effective cancer treatments using PDT. In this regard, semiconducting quantum dots have shown encouraging results. Quantum dots are artificial semiconducting nanocrystals with distinct chemical and physical properties. Their optical properties can be fine-tuned by varying their size, which usually ranges from 1 to 10 nm. They present many advantages over conventional photosensitizers, mainly their emission properties can be manipulated within the near IR region as opposed to the visible region by the former. Consequently, low intensity light can be used to penetrate deeper tissues owing to low scattering in the near IR region. Recently, successful reports on imaging and PDT of cancer using carbon (carbon, graphene based) and metallic (Cd based) based quantum dots are promising. This review aims to summarize the development and the status quo of quantum dots for cancer treatment.

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A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

Tian

Liu

et al. 2023

Adv Funct Materials

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As a less O 2 -dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia-induced low efficiency against solid tumors. However, the commonly used metal-involved agents suffer from the long-term biosafety concern. Herein, a metal-free type I photosensitizer, N-doped carbon dots/mesoporous silica nanoparticles (NCDs/ MSN, ≈40 nm) nanohybrid with peroxidase (POD)-like activity for synergistic PDT and enzyme-activity treatment, is developed on gram scale via a facile one-pot strategy through mixing carbon source and silica precursor with the assistance of template. Benefiting from the narrow bandgap (1.92 eV) and good charge separation capacity of NCDs/MSN, upon 640 nm light irradiation, the excited electrons in the conduction band can effectively generate O 2 •− by reduction of dissolved O 2 via a one-electron transfer process even under hypoxic conditions, inducing apoptosis of tumor cells. Moreover, the photoinduced O 2 •− can partially transform into more toxic • OH through a two-electron reduction. Moreover, the POD-like activity of NCDs/MSN can catalyze the endogenous H 2 O 2 to • OH in the tumor microenvironment, further synergistically ablating 4T1 tumor cells. Therefore, a mass production way to synthesize a novel metal-free type I photosensitizer with enzymemimic activity for synergistic treatment of hypoxic tumors is provided, which exhibits promising clinical translation prospects.

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F,N-Doped carbon dots as efficient Type I photosensitizers for photodynamic therapy

Abstract: Photodynamic therapy (PDT) is a promising and emerging method for the treatment of cancer, usually Type II PDT is used in the clinic, which is mainly consists of three key...

Cited by 56 publications

References 50 publications

One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection

One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection

Semiconductor quantum dots for photodynamic therapy: Recent advances

A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

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