F4H5: a novel substance for the removal of silicone oil from intraocular lenses

Abstract

F4H5 was highly effective at removing the bulk of the silicone oil from all three groups of IOL. The DCA measurements suggested that their surface properties were permanently modified.

Screening of semifluorinated n‐alkanes by gas chromatography coupled to dielectric barrier discharge ionization mass spectrometry

“…In ophthalmology mainly diblock SFAs with linear short chain lengths, namely F4H5 and F6H8, are used. F4H5 is employed as a wash‐out solvent for removing silicone oil residues from the retina and for cleaning intraocular lenses after silicone oil tamponades in retinal surgery . In contrast to F4H5, F6H8 (see Figure ) is applied as an intra‐operative tamponade, functioning as vitreous substitute .…”

Special Adjuncts to Treatment

“…SO in contact with the posterior surface of the intraocular lens would greatly reduce the refractive power. [192][193][194][195] In a recent laboratory study by Stappler and colleagues, F 4 H 5 , a hydrophobic semifluorinated alkane, was used to dissolve adherent SO droplets on IOLs. There are intraocular lenses specifically designed for the use of SO, with a concave posterior surface, such that the intended final correction will be correct even with SO in situ.…”

“…Most intraocular lenses have biconvex configuration. 193 With a simple immersion, over 91.4% of SO droplets were successfully washed off the surface of IOLs. 188 With the introduction of PMMA and acrylic IOLs, the use of silicone IOLs have become less popular.…”

Vitreoretinal Surgery

“…with a pre-existing missed hole in the retina, as very seldom is the intact retina torn during silicone oil injection (Stappler et al 2010 ) .…”