F702 Histological Findings Using Novel Stimulation Parameters in a Caprine Model

Butt, Mark T.; Alataris, Konstantinos; Walker, Andre; Tiede, Jeffrey M

doi:10.1016/s1754-3207(11)70648-4

Cited by 14 publications

(7 citation statements)

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“…Both the European multicenter study at two years (13) and the Tiede et al multicenter trial in the USA (24) were without neurologic adverse events related to the use of high-frequency 10-kHz SCS. Preclinical work has also confirmed the safety of continuous highfrequency 10-kHz SCS in an animal model (25). Our study is, to our knowledge, the first to report clinical results in patients implanted with cervical leads using high-frequency 10-kHz SCS, and confirms the safety of its use.…”

Section: Safety Of High-frequency 10-khz Scssupporting

confidence: 75%

The Use of 10-Kilohertz Spinal Cord Stimulation in a Cohort of Patients With Chronic Neuropathic Limb Pain Refractory to Medical Management

Al‐Kaisy

Palmisani

Smith

et al. 2015

Neuromodulation: Technology at the Neural Interface

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Section: Safety Of High-frequency 10-khz Scssupporting

confidence: 75%

The Use of 10-Kilohertz Spinal Cord Stimulation in a Cohort of Patients With Chronic Neuropathic Limb Pain Refractory to Medical Management

Al‐Kaisy

Palmisani

Smith

et al. 2015

Neuromodulation: Technology at the Neural Interface

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“…Any unwanted perception alterations were eliminated with reprogramming, including one such occasion when the patient was utilizing standard stimulation parameters. Of note, histological animal studies produced no pathologic consequences of stimulation with these investigational high‐frequency parameters . The current delivery per second is directly affected by amplitude and pulse width, and not frequency.…”

Section: Discussionmentioning

confidence: 80%

Novel Spinal Cord Stimulation Parameters in Patients with Predominant Back Pain

Tiede

Brown

Gekht

et al. 2013

Neuromodulation: Technology at the Neural Interface

169

129

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“…KHFAC was applied to the spinal cord of six goats for 24 hours/day for ten days (240 continuous hours) . Blinded comparison of histological spinal cord samples from the KHFAC animals and six control animals indicated no morphological differences between the two groups.…”

Section: Characteristics Of Khfac Blockmentioning

confidence: 99%

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Kilgore

Bhadra

2014

Neuromodulation: Technology at the Neural Interface

217

231

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Objectives The features and clinical applications of balanced-charge kilohertz frequency alternating currents (KHFAC) are reviewed. Preclinical studies of KHFAC block have demonstrated that it can produce an extremely rapid and reversible block of nerve conduction. Recent systematic analysis and experimentation utilizing KHFAC block has resulted in a significant increase in interest in KHFAC block, both scientifically and clinically. Materials and Methods We review the history and characteristics of KHFAC block, the methods used to investigate this type of block, the experimental evaluation of block, and the electrical parameters and electrode designs needed to achieve successful block. We then analyze the existing clinical applications of high frequency currents, comparing the early results with the known features of KHFAC block. Results Although many features of KHFAC block have been characterized, there is still much that is unknown regarding the response of neural structures to rapidly fluctuating electrical fields. The clinical reports to date do not provide sufficient information to properly evaluate the mechanisms that result in successful or unsuccessful treatment. Conclusions KHFAC nerve block has significant potential as a means of controlling nerve activity for the purpose of treating disease. However, early clinical studies in the use of high frequency currents for the treatment of pain have not been designed to elucidate mechanisms or allow direct comparisons to preclinical data. We strongly encourage the careful reporting of the parameters utilized in these clinical studies, as well as the development of outcome measures that could illuminate the mechanisms of this modality.

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F702 Histological Findings Using Novel Stimulation Parameters in a Caprine Model

Cited by 14 publications

References 0 publications

The Use of 10-Kilohertz Spinal Cord Stimulation in a Cohort of Patients With Chronic Neuropathic Limb Pain Refractory to Medical Management

The Use of 10-Kilohertz Spinal Cord Stimulation in a Cohort of Patients With Chronic Neuropathic Limb Pain Refractory to Medical Management

Novel Spinal Cord Stimulation Parameters in Patients with Predominant Back Pain

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

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