FABP-2 and PPAR-γ Haplotype as Risk Factors for Dyslipidemia in a Type 2 Diabetes Mellitus Population of Santa Rosa del Conlara, San Luis, Argentina

Siewert, Susana; Nicotra, María Florencia Olmos; González, Irma; Fernández, Gustavo; Ojeda, Marta Susana

doi:10.4236/oalib.1100967

Cited by 1 publication

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various candidate genes are involved in the regulation of exogenous and endogenous triglycerides, among them FABP‐2 acts during intestinal absorption of dietary fat (Siewert et al, 2014). A single nucleotide polymorphism at codon 54 in exon 2 of FABP‐2 results in an amino acid substitution of alanine (wild) to threonine (mutant) in the encoded protein (Kops et al, 2017), associated with an increased affinity of the Thr54 FABP‐2 (as compared with the Ala54 FABP‐2 ) protein for long chain fatty acids (Baier et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of fatty acid binding protein‐2 in hyperlipidemic Asian Indians in North India

Meena

Misra

Vikram

et al. 2022

American J Hum Biol

View full text Add to dashboard Cite

Background Fatty acid binding protein‐2 (FABP‐2) is involved in the metabolism of lipids in the intestine. FABP‐2 Ala54Thr polymorphism involves a transition of G to A at codon 54 of FABP‐2, resulting in an amino acid substitution Ala54 to Thr54 and is associated with elevated fasting triglycerides in some hyperlipidemic populations. In current genome builds and gene databases the variant of the Ala54Thr FABP‐2 (rs 1 799 883) is annotated as c.163A>G (p. Thr55Ala). Aim and Objective The status of this polymorphism in hyperlipidemic Asian Indians from North India has not been investigated. This study was aimed to evaluate the distribution of the polymorphic variants of the Ala54Thr FABP‐2 and their association with lipids in hyperlipidemic subjects. Methods Ala54Thr FABP‐2 polymorphism in both hyperlipidemic (n = 210) and normolipidemic (n = 342) subjects was assessed by PCR‐RFLP. Results Ala54Thr genotypes and alleles distribution did not differ between the hyperlipidemic and normolipidemic groups. The heterozygous genotype FABP‐2 Ala/Thr was significantly associated with higher levels of triglycerides and very low‐density lipoproteins as compared to the homozygous variant (Thr/Thr) genotype and the wild type homozygous (Ala/Ala) genotype. Conclusions The heterozygous genotype FABP‐2 Ala54Thr is a risk factor for the development of hypertriglyceridemia and increased levels of VLDL‐c in Asian Indians from North India.

show abstract

Section: Introductionmentioning

confidence: 99%