Fabricating Composite Cell Sheets for Wound Healing: Cell Sheets Based on the Communication Between BMSCs and HFSCs Facilitate Full-Thickness Cutaneous Wound Healing

Li, Gongjian; Wang, Qin; Liu, Hao; Yang, Zuojun; Wu, Yuhan; He, Li; Deng, Xiaoyuan

doi:10.1007/s13770-023-00614-0

Cited by 1 publication

(1 citation statement)

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“…HFSCs represent a distinct category of stem cells localized within HF, characterized by unique biological attributes and functionalities primarily implicated in the growth, development, and regeneration of hair. Notably, HFSCs are not only pivotal for fostering hair growth but also play a crucial role in the reparative processes of skin wounds [1][2][3]. Substantial evidence supports the assertion that HFSCs assume a central position within multiple skin components surrounding tissue HF thereby functioning as key tissue centers during adult skin homeostasis.…”

Section: Introductionmentioning

confidence: 88%

Hair Follicle Stem Cells: the Signaling Hub of the Skin

Tan,

Chang

2024

J Cell Immunol

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Hair follicle stem cells (HFSCs) are recognized as multipotential stem cells with exceptional proliferative capacity. Their regulatory effect on skin homeostasis is orchestrated through intricate signaling pathways, including Wnt/β-catenin, transforming growth factor-β/bone morphogenetic protein (TGFβ/BMP), Notch, and Hedgehog. Concurrently, HFSCs inhabit the bulge region of the outer root sheath of the hair follicle (HF), serving as the epicenter for skin-organizing signaling during homeostasis, engaging in dynamic interactions with other functionally specialized niche cells. This comprehensive review delineates the nuanced interplay of both cell-intrinsic and cell-extrinsic mechanisms governing HFSCs within the skin. The aspiration is that this synthesis of knowledge will contribute meaningfully to the theoretical foundations underpinning further investigations into skin disorders.

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Section: Introductionmentioning

confidence: 88%