Fabrication and Characterization of Nonplanar Microelectrode Array Circuits for Use in Arthroscopic Diagnosis of Cartilage Diseases

Quenneville, É.; Binette, Julie; Garon, M.; Légaré, A.; Meunier, M.; Buschmann, Michael D.

doi:10.1109/tbme.2004.836522

Cited by 14 publications

(13 citation statements)

References 34 publications

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“…Berkenblit et al (1994) proposed that techniques for detection of the electrokinetic properties were useful for nondestructive measurement of osteoarthritis. Quenneville et al (2004) developed a microelectrode array device for the detection of the streaming potential during diagnosis of the state of cartilage. These studies indicated that load-bearing tissue such as cartilage and discs could be evaluated using streaming potential measurements.…”

Section: Discussionmentioning

confidence: 99%

Relationship between streaming potential and compressive stress in bovine intervertebral tissue

Fujisaki

Tadano

Asano

2011

Journal of Biomechanics

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The intervertebral disc is formed by the nucleus pulposus (NP) and annulus fibrosus (AF), and intervertebral tissue contains a large amount of negatively charged proteoglycan. When this tissue becomes deformed, a streaming potential is induced by liquid flow with positive ions. The anisotropic property of the AF tissue is caused by the structural anisotropy of the solid phase and the liquid phase flowing into the tissue with the streaming potential. This study investigated the relationship between the streaming potential and applied stress in bovine intervertebral tissue while focusing on the anisotropy and loading location. Column-shaped specimens, 5.5 mm in diameter and 3 mm thick, were prepared from tissue of the AF, NP, and the annulus-nucleus transition region (AN). The loading direction of each specimen was oriented in the spinal axial direction, as well as in the circumferential and radial directions of the spine considering the anisotropic properties of the AF tissue. The streaming potential changed linearly with stress in all specimens. The linear coefficients k e of the relationship between stress and streaming potential depended on the extracted positions. These coefficients were not affected by the anisotropy of the AF tissue. In addition, these coefficients were lower in AF than in NP specimens. Except in the NP specimen, the k e values were higher under faster compression rate conditions. In cyclic compression loading, the streaming potential changed linearly with compressive stress, regardless of differences in the tissue and load frequency.

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Section: Discussionmentioning

confidence: 99%

Relationship between streaming potential and compressive stress in bovine intervertebral tissue

Fujisaki

Tadano

Asano

2011

Journal of Biomechanics

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“…Two reservoirs, inner and outer, were filled with phosphate buffered saline solution (0.145 M, pH 7.3 [16,17]. The two reservoirs were connected by the sample.…”

Section: Methodsmentioning

confidence: 99%

Investigation of pressure loading rates on streaming potentials in bone

Hou

Wang

2011

Sci. China Technol. Sci.

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When load is applied to bone, it deforms and causes fluid pressure to build up in bone. The pressure gradient between different portions of the bone microcnannels drives fluid flow through them. This kind of bone fluid flow can induces the streaming potentials which are considered to play a role for bone remodeling. Aimed to determine the impact of ribbed rough inner surfaces of the microchannels on the streaming potentials, streaming potentials were measured as bone fluid flowed through the mcrospaces of thin cylinder bone samples under different pressure loading rates. The results show that the streaming potentials decrease with the increase of the pressure loading rates. A digital simulation calculation was performed and the results demonstrated that there were turbulent flows near the inner wall surfaces, which making the streaming potentials smaller in bone microchannels.bone, streaming potentials, pressure rising rate, turbulent flow Citation:

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“…For phase shift lithography, it would be quite difficult to engineer the phase mask to correct for the mechanical deformations, and thus elimination of the distortions would likely require manipulation of the exposure conditions. [22] Advances in microfabrication, namely in the area of nonplanar electronic devices, such as curved photodiode arrays for solar cell applications and synthetic retinal implants, [36][37][38][39][40] demand the ability to pattern metals, and other materials with electrical functionality, on geometrically diverse surfaces. The aforementioned fabrication methods are intended to replace traditional contact lithography by finding novel ways to use PDMS as a patterning element.…”

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confidence: 99%

Fabrication of Flexible Binary Amplitude Masks for Patterning on Highly Curved Surfaces

Bowen

Nuzzo

2009

Adv Funct Materials

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This paper describes soft lithography methods that expand current fabrication capabilities by enabling high‐throughput patterning on nonplanar substrates. These techniques exploit optically dense elastomeric mask elements embedded in a transparent poly(dimethylsiloxane) (PDMS) matrix by vacuum‐assisted microfluidic patterning, UV–ozone‐mediated irreversible sealing, and chemical etching. These protocols provide highly flexible photomasks exhibiting either positive‐ or negative‐image contrasts, which serve as amplitude masks for large‐area photolithographic patterning on a variety of curved (and planar) surfaces. When patterning on cylindrical surfaces, the developed masks do not experience significant pattern distortions. For substrates with 3D curvatures/geometries, however, the PDMS mask must undergo relatively large strains in order to make conformal contact. The new methods described in this report provide planar masks that can be patterned to compliantly compensate for both the displacements and distortions of features that result from stretching the mask to span the 3D geometry. To demonstrate this, a distortion‐corrected grid pattern mask was fabricated and used in conjunction with a homemade inflation device to pattern an electrode mesh on a glass hemisphere with predictable registration and distortion compensation. The showcased mask fabrication processes are compatible with a broad range of substrates, illustrating the potential for development of complex lithographic patterns for a variety of applications in the realm of curved electronics (i.e., synthetic retinal implants and curved LED arrays) and wide field‐of‐view optics.

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Fabrication and Characterization of Nonplanar Microelectrode Array Circuits for Use in Arthroscopic Diagnosis of Cartilage Diseases

Cited by 14 publications

References 34 publications

Relationship between streaming potential and compressive stress in bovine intervertebral tissue

Relationship between streaming potential and compressive stress in bovine intervertebral tissue

Investigation of pressure loading rates on streaming potentials in bone

Fabrication of Flexible Binary Amplitude Masks for Patterning on Highly Curved Surfaces

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