Fabrication and In Vitro Characterization of Novel Hydroxyapatite Scaffolds 3D Printed Using Polyvinyl Alcohol as A Thermoplastic Binder

Thurzo, Andrej; Gálfiová, Paulína; Nováková, Zuzana; Polák, Štefan; Varga, Ivan; Strunga, Martin; Urban, Renata R.; Surovková, Jana; Leško, Ľuboš; Hajdúchová, Zora; Feranc, Jozef; Janek, M.; Danišovič, Ľuboš

doi:10.20944/preprints202211.0141.v1

2022

DOI: 10.20944/preprints202211.0141.v1

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Fabrication and In Vitro Characterization of Novel Hydroxyapatite Scaffolds 3D Printed Using Polyvinyl Alcohol as A Thermoplastic Binder

Andrej Thurzo¹,

Paulína Gálfiová²,

Zuzana Nováková³

et al.

Abstract: This paper presents a proof-of-concept study on the biocolonization of 3D-printed hydroxyapatite scaffolds with mesenchymal stem cells (MSCs). Three-dimensional (3D) printed biomimetic bone structure made of Calcium Deficient HydroxyApatite (CDHA) intended as future bone graft was made from newly developed composite material for FDM printing. The biopolymer polyvinyl alcohol serves in this material as a thermoplastic binder for 3D molding of the printed object with a passive function and is completely removed … Show more

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Cited by 14 publications

References 42 publications

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Primary Stability Assessment of Conical Implants in Under-Prepared Sites: An In Vitro Study in Low-Density Polyurethane Foams

Comuzzi

Tumedei

Covani³

et al. 2023

Applied Sciences

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Bone characteristics, the implant macrogeometry, and the drilling technique are considered the main important factors to obtain a good implant primary stability (PS). Indeed, although it is known that implant placement in poor bone sites increases the possibility of implant failure, several surgical procedures have been proposed to improve PS, such as site under-preparation. Hence, this in vitro study aimed to evaluate the insertion torque (IT), removal torque (RT), and resonance frequency analysis (RFA) of conical implants (3.3 and 4 × 13 mm) placed in under-prepared sites on 10 and 20 pounds per cubic foot (PCF) density polyurethane sheets (simulating a D3 and D2 bone, respectively) with and without a cortical sheet of 30 PCF in density (corresponding to a D1 bone). After using ANOVA or Kolmogorov–Smirnov test to elaborate data, the resulting IT and RT values were directly proportional to the polyurethane block densities (e.g., the lowest and highest IT values were 8.36 ± 0.52 Ncm in the 10 PCF density sheet and 46.21 ± 0.79 Ncm in the 20 PCF density sheet + cortical for 4 × 13 mm implants) and increased with the increasing amount of site under-preparation (the highest results for both implants were found with a 2.2 mm under-preparation, showing a significantly higher IT with a p < 0.05 compared with others, especially in the highest-density sheets). Both implants inserted in the 20 PCF density block + cortical with all under-preparation protocols exhibited significantly higher RFA values (p < 0.05–0.0001) compared with the corresponding ones in the 10 PCF block. Moreover, 3.3 × 13 mm implants showed the same results comparing the 20 PCF block and the 10 PCF block + cortical. In conclusion, in this in vitro study using low-density polyurethane blocks, the under-preparation of the implant insertion sites was shown to be effective in increasing implants’ PS.

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Primary Stability Assessment of Conical Implants in Under-Prepared Sites: An In Vitro Study in Low-Density Polyurethane Foams

Comuzzi

Tumedei

Covani³

et al. 2023

Applied Sciences

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show abstract

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Gašparovič,

Jungová,

Tomášik

et al. 2024

Applied Sciences

Self Cite

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Regenerative dentistry has experienced remarkable advancement in recent years. The interdisciplinary discoveries in stem cell applications and scaffold design and fabrication, including novel techniques and biomaterials, have demonstrated immense potential in the field of tissue engineering and regenerative therapy. Scaffolds play a pivotal role in regenerative dentistry by facilitating tissue regeneration and restoring damaged or missing dental structures. These biocompatible and biomimetic structures serve as a temporary framework for cells to adhere, proliferate, and differentiate into functional tissues. This review provides a concise overview of the evolution of scaffold strategies in regenerative dentistry, along with a novel analysis (Bard v2.0 based on the Gemini neural network architecture) of the most commonly employed materials used for scaffold fabrication during the last 10 years. Additionally, it delves into bioprinting, stem cell colonization techniques and procedures, and outlines the prospects of regenerating a whole tooth in the future. Moreover, it discusses the optimal conditions for maximizing mesenchymal stem cell utilization and optimizing scaffold design and personalization through precise 3D bioprinting. This review highlights the recent advancements in scaffold development, particularly with the advent of 3D bioprinting technologies, and is based on a comprehensive literature search of the most influential recent publications in this field.

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Literature Review of an Anterior Deprogrammer to Determine the Centric Relation and Presentation of Cases

Danko,

Chromy,

Ferencik

et al. 2023

Bioengineering

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The increasing demand for dental aesthetics, articulation corrections, and solutions for pain and frequent bruxism demands quick and effective restorative dental management. The biomedical research aimed to create a beneficial, ecological, and readily available anterior deprogrammer to determine the centric relation (CR) of cases. This medical device is additively manufactured from a biocompatible material. Size is customizable based on the width of the patient’s anterior central incisors. This is a pilot study with two subjects. The task was to develop a complete data protocol for the production process, computer-aided design (CAD), and three-dimensional (3D) printing of the anterior deprogrammers. The research focused on creating simple and practically applicable tools for the dentist’s prescription (anterior deprogrammer in three sizes), and secondly for the communication between the dentist and the patient (computer application). The tested hypothesis was whether, according to these novel tools, it is possible to produce functional occlusal splints, which could be manufactured using current technologies. This study compared a traditional splint with a digitally designed and 3D-printed one. The tested hypothesis was whether manufactured occlusal splints differ in patients’ subjective perception of comfort. Each conservative treatment was monitored for ten weeks. Initial results are promising; no statistically significant difference was found between the productive technologies.

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Fabrication and In Vitro Characterization of Novel Hydroxyapatite Scaffolds 3D Printed Using Polyvinyl Alcohol as A Thermoplastic Binder

Cited by 14 publications

References 42 publications

Primary Stability Assessment of Conical Implants in Under-Prepared Sites: An In Vitro Study in Low-Density Polyurethane Foams

Primary Stability Assessment of Conical Implants in Under-Prepared Sites: An In Vitro Study in Low-Density Polyurethane Foams

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Literature Review of an Anterior Deprogrammer to Determine the Centric Relation and Presentation of Cases

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