Fabrication and in vitro characterization of macroporous WS2/ bioactive glass scaffolds for biomedical applications

Ensoylu, Mertcan; Atmaca, Harika; Deliormanlı, Aylin M.

doi:10.1007/s41779-021-00696-w

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…This Special Issue presents eleven contributions submitted by scholars with renowned backgrounds in scaffolds design, fabrication, functionalization, or clinical applications [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]; four of these contributions are valuable review articles, and seven are original new research articles. Thematically, according to the area of application, the contributions can be grouped into articles concerning the following:…”

Section: Introductionmentioning

confidence: 99%

Advances in Biomimetic Scaffolds for Hard Tissue Surgery

Uklejewski,

Winiecki

2024

Biomimetics

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Section: Introductionmentioning

confidence: 99%

Advances in Biomimetic Scaffolds for Hard Tissue Surgery

Uklejewski,

Winiecki

2024

Biomimetics

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“…To overcome this limitation, the preparation of the bioactive glass matrix composites in the presence of two dimensional nanomaterials and also polymer coatings are commonly employed. Previously, the inclusion of pristine graphene [ 8 , 9 , 10 , 11 ], graphene oxide [ 12 , 13 ], and tungsten disulfide [ 14 , 15 ] in bioactive glasses has been reported. In general, the use of the aforementioned two dimensional materials in the glass network improved the mechanical properties of the composites.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

2022

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In this study, biomimetic borate-based bioactive glass scaffolds containing hexagonal boron nitride hBN nanoparticles (0.1, 0.2, 0.5, 1, and 2% by weight) were manufactured with the polymer foam replication technique to be used in hard tissue engineering and drug delivery applications. To create three-dimensional cylindrical-shaped scaffolds, polyurethane foams were used as templates and covered using a suspension of glass and hBN powder mixture. Then, a heat treatment was applied at 570 °C in an air atmosphere to remove the polymer foam from the structure and to sinter the glass structures. The structural, morphological, and mechanical properties of the fabricated composites were examined in detail. The in vitro bioactivity of the prepared composites was tested in simulated body fluid, and the release behavior of gentamicin sulfate and 5-fluorouracil from glass scaffolds were analyzed separately as a function of time. The cytotoxicity was investigated using osteoblastic MC3T3-E1 cells. The findings indicated that the hBN nanoparticles, up to a certain concentration in the glass matrix, improved the mechanical strength of the glass scaffolds, which mimic the cancellous bone. Additionally, the inclusion of hBN nanoparticles enhanced the in vitro hydroxyapatite-forming ability of bioactive glass composites. The presence of hBN nanoparticles accelerated the drug release rates of the system. It was concluded that bioactive glass/hBN composite scaffolds mimicking native bone tissue could be used for bone tissue repair and regeneration applications.

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