Fabrication, bacteriostasis and osteointegration properties researches of the additively-manufactured porous tantalum scaffolds loading vancomycin

Hu, Qian-Nan; Lei, Ting; Long, Hua; Wang, Dongyu; Nan, Jiangyu; Liu, Wenbin; Sun, Yan; Hu, Yihe; Lei, Pengfei

doi:10.1016/j.bioactmat.2022.12.013

Cited by 21 publications

(14 citation statements)

References 48 publications

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“…The importance of antimicrobial resistance needs to be taken into account in the clinical treatment of infected bone defects. Qian et al 57 constructed a composite Ta/GelMA/PLGA/Van scaffold, which not only loaded vancomycin (Van) to achieve excellent bacterial inhibition, but also had good biocompatibility and osseointegration ability. Innervation is an important initiator of bone regeneration and is involved in the process of bone growth and repair, so the importance of nerve regeneration needs to be taken into account when using tissue-engineered scaffolds to repair bone defects.…”

Section: Application Of Gelma Hydrogel In Musculoskeletal Diseases Ge...mentioning

confidence: 99%

“…For infected bone defects, clinical treatment often involves debridement and infection control followed by bone repair, but the results are not satisfactory. Therefore, Qian et al 57 developed a new composite Ta/GelMA/PLGA/Van scaffold that has promising antimicrobial and bone regeneration capabilities and shows clear potential for clinical use. Recent studies have also found that engineered hydrogel microspheres for oxygen metabolic homeostasis (GM@CS-BP) can regulate ECM metabolic homeostasis in the myeloid nucleus and reduce the inflammatory response, providing a promising approach for the treatment of IVDD 99 .…”

Section: Clinical Translations Of Gelma Hydrogels In Musculoskeletal ...mentioning

confidence: 99%

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Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

Lv¹,

Li²,

Hu³

et al. 2023

Theranostics

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Increasing data reveals that gelatin that has been methacrylated is involved in a variety of physiologic processes that are important for therapeutic interventions. Gelatin methacryloyl (GelMA) hydrogel is a highly attractive hydrogels-based bioink because of its good biocompatibility, low cost, and photo-cross-linking structure that is useful for cell survivability and cell monitoring. Methacrylated gelatin (GelMA) has established itself as a typical hydrogel composition with extensive biomedical applications. Recent advances in GelMA have focused on integrating them with bioactive and functional nanomaterials, with the goal of improving GelMA's physical, chemical, and biological properties. GelMA's ability to modify characteristics due to the synthesis technique also makes it a good choice for soft and hard tissues. GelMA has been established to become an independent or supplementary technology for musculoskeletal problems. Here, we systematically review mechanism-of-action, therapeutic uses, and challenges and future direction of GelMA in musculoskeletal disorders. We give an overview of GelMA nanocomposite for different applications in musculoskeletal disorders, such as osteoarthritis, intervertebral disc degeneration, bone regeneration, tendon disorders and so on.

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Section: Application Of Gelma Hydrogel In Musculoskeletal Diseases Ge...mentioning

confidence: 99%

Section: Clinical Translations Of Gelma Hydrogels In Musculoskeletal ...mentioning

confidence: 99%

Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

Lv¹,

Li²,

Hu³

et al. 2023

Theranostics

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show abstract

“…In mouse and sheep models, the intervertebral fusion cage constructed by this method can prevent trauma and complications at the donor site and achieve similar fusion performance and osseointegration. 108 This approach involves the autogenous bone extracted during surgery. However, the preparation steps are complicated, and it is impossible to construct a fusion cage defect between the vertebral bodies with a fine structure.…”

Section: Tantalummentioning

confidence: 99%

“…Yuan et al prepared polyetheretherketone/calcium silicate (CS) composite ceramics having an interbody fusion cage shape by injection molding and filled them with porous tantalum metal blocks of appropriate size and autologous bone. In mouse and sheep models, the intervertebral fusion cage constructed by this method can prevent trauma and complications at the donor site and achieve similar fusion performance and osseointegration 108 . This approach involves the autogenous bone extracted during surgery.…”

Section: Tissue Engineering Scaffolds Doped With Metallic Elementsmentioning

confidence: 99%

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

He,

Li,

et al. 2023

MedComm – Biomaterials and Applications

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The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable metal‐based scaffolds, including metal‐based scaffolds and multifunctional scaffolds doped with metal elements, are a rapidly developing tissue engineering strategy aimed at utilizing the mechanical and biological properties of metal elements to create a support structure that matches the complex bone regeneration environment. Repairing bone defects involves the regeneration of various tissues, and incomplete repair can negatively affect bone function and overall recovery. Therefore, combining metal‐based degradable materials with other active components has great potential for enhancing the versatility and clinical applications of scaffolds. Multifunctional scaffolds doped with metal elements have better biocompatibility, osteoinductivity, biodegradability, matching mechanical, and microenvironmental adjustment capabilities. Moreover, these metal‐doped scaffolds possess the advantages of controlled release of metal ions, multifunctionality, and faster degradation. This review focuses on the materials and techniques used for constructing degradable metal‐based scaffolds. Furthermore, this study discussed the potential for designing and constructing multifunctional biodegradable metal‐based scaffolds doped with metal elements by integrating multiple strategies.

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“…But current methods are not very effective as antibiotic overuse can lead to systemic toxicity, emergence of drug-resistant bacteria, and the need for an additional surgery, leading to additional trauma for the patient and financial burden. 8 Moreover, the drug-resistant pathogens existing in the maxillofacial region pose a severe threat to public health by causing severe infections that result in high morbidity and mortality. 9 Therefore, there is an urgent need to develop new therapeutic materials to combat these infection fortunately, researchers have devoted themselves to investigating advanced reparative materials for bone defects to achieve the remodeling of the normal bone structure and function.…”

Section: Introductionmentioning

confidence: 99%

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Han,

Xiong,

Jin

et al. 2024

J. Mater. Chem. B

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Fabrication, bacteriostasis and osteointegration properties researches of the additively-manufactured porous tantalum scaffolds loading vancomycin

Cited by 21 publications

References 48 publications

Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

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