Fabrication, characterization, and controlled release of eprinomectin from injectable mesoporous PLGA microspheres

Shang, Qianqian; Zhai, Jianhua; Tian, Ruiqiong; Zheng, Ting; Zhang, Xiaoyun; Liang, Xiaoyang; Zhang, Jing

doi:10.1039/c5ra12262g

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…The main Porous microspheres (PMS) have found their application in drug delivery, adsorption and separation, catalysis, and cargo for small molecules, due to their high specific surface area, high permeability, stability, and low density. Particularly, healable PMS attracted special attention because of their unique advantages in guest carrying and control release .…”

Section: Introductionmentioning

confidence: 99%

Microspheres with Tunable Porosity Based on Reactive Block Copolymer: Preparation and Vapor‐Healing Behavior

Deng

Tan

Zhao

et al. 2019

Macro Chemistry & Physics

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Herein, a simple route to prepare porous microspheres with tuned pore structure and potential functionality based on epoxy functionalized block copolymers, poly hydroxypropyl methacrylate‐b‐ poly glycidyl methacrylate (PHPMA‐b‐PGMA), through a water‐in‐oil‐in‐water (W/O/W) double emulsion is reported. The effect of surfactant concentration and the composition of block copolymers are investigated. The solvent vapor swelling behavior of porous microspheres before and after cross‐linking is studied. It is interesting that after the swelling, the cross‐linked open pores are self‐healed to form closed pores, whereas the uncross‐linked ones are collapsed. It is believed that this observation will be useful in guest carrying and control release, and find its application in biomedical and pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Microspheres with Tunable Porosity Based on Reactive Block Copolymer: Preparation and Vapor‐Healing Behavior

Deng

Tan

Zhao

et al. 2019

Macro Chemistry & Physics

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“…The solid phase diversity of pharmaceutical molecules, including pharmaceutical polymorphs, [1][2][3][4][5][6] pseudo polymorphs, 7,8 salts, 9,10 co-crystals, [11][12][13] and amorphous solids, [14][15][16] has become a major hotspot in contemporary drug research, because of the unique physicochemical properties, efficacy, and toxic side effects existing in different solid forms. Pharmaceutical solid form screening has rapidly developed into a general approach to enhance the physicochemical properties of drugs, 17,18 which can remarkably affect their solubility 3,19,20 bioavailability, [21][22][23] hygroscopicity, 20,24 melting point, 3,25 stability, 26,27 and mechanical properties, 28 especially their compressibility, 13,20 and tabletability.…”

Section: Introductionmentioning

confidence: 99%

Four solid forms of tauroursodeoxycholic acid and solid-state transformations: effects of temperature and milling

Zheng

Guo

et al. 2015

RSC Adv.

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Tissue Engineered Bio‐Blood‐Vessels Constructed Using a Tissue‐Specific Bioink and 3D Coaxial Cell Printing Technique: A Novel Therapy for Ischemic Disease

Gao

Lee

Jang

et al. 2017

Adv Funct Materials

274

188

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Endothelial progenitor cells (EPCs) are a promising cell source for the treatment of several ischemic diseases for their potentials in neovascularization. However, the application of EPCs in cell-based therapy has shown low therapeutic efficacy due to hostile tissue conditions after ischemia. In this study, a bio-blood-vessel (BBV) is developed, which is produced using a novel hybrid bioink (a mixture of vascular-tissue-derived decellularized extracellular matrix (VdECM) and alginate) and a versatile 3D coaxial cell printing method for delivering EPC and proangiogenic drugs (atorvastatin) to the ischemic injury sites. The hybrid bioink not only provides a favorable environment to promote the proliferation, differentiation, and neovascularization of EPCs but also enables a direct fabrication of tubular BBV. By controlling the printing parameters, the printing method allows to construct BBVs in desired dimensions, carrying both EPCs and atorvastatin-loaded poly(lactic-co-glycolic) acid microspheres. The therapeutic efficacy of cell/drug-laden BBVs is evaluated in an ischemia model at nude mouse hind limb, which exhibits enhanced survival and differentiation of EPCs, increased rate of neovascularization, and remarkable salvage of ischemic limbs. These outcomes suggest that the 3D-printed ECM-mediated cell/drug implantation can be a new therapeutic approach for the treatment of various ischemic diseases.

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Fabrication, characterization, and controlled release of eprinomectin from injectable mesoporous PLGA microspheres

Abstract: Batches of mesoporous poly(lactide-co-glycolide) (PLGA) microspheres were fabricated via an O/W emulsion–solvent evaporation method.

Cited by 7 publications

References 32 publications

Microspheres with Tunable Porosity Based on Reactive Block Copolymer: Preparation and Vapor‐Healing Behavior

Microspheres with Tunable Porosity Based on Reactive Block Copolymer: Preparation and Vapor‐Healing Behavior

Four solid forms of tauroursodeoxycholic acid and solid-state transformations: effects of temperature and milling

Tissue Engineered Bio‐Blood‐Vessels Constructed Using a Tissue‐Specific Bioink and 3D Coaxial Cell Printing Technique: A Novel Therapy for Ischemic Disease

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