Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling Technology

Chen, Hao; Zheng, Kai; Bu, Tianshi; Li, Xin; Wang, Xiangyu; Pan, Hao

doi:10.1208/s12249-024-02757-2

AAPS PharmSciTech

2024

DOI: 10.1208/s12249-024-02757-2

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Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling Technology

Hao Chen,

Kai Zheng,

Tianshi Bu

et al.

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2024

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Cited by 2 publications

References 67 publications

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Development of Mathematical Function Control-Based 3D Printed Tablets and Effect on Drug Release

Wang,

Karnik,

Uttreja

et al. 2024

Pharm Res

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Purpose The application of 3D printing technology in drug delivery is often limited by the challenges of achieving precise control over drug release profiles. The goal of this study was to apply surface equations to construct 3D printed tablet models, adjust the functional parameters to obtain multiple tablet models and to correlate the model parameters with the in vitro drug release behavior. Methods This study reports the development of 3D-printed tablets using surface geometries controlled by mathematical functions to modulate drug release. Utilizing fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) technology, personalized drug delivery systems were produced using thermoplastic polymers. Different tablet shapes (T1-T5) were produced by varying the depth of the parabolic surface (b = 4, 2, 0, -2, -4 mm) to assess the impact of surface curvature on drug dissolution. Results The T5 formulation, with the greatest surface curvature, demonstrated the fastest drug release, achieving complete release within 4 h. In contrast, T1 and T2 tablets exhibited a slower release over approximately 6 h. The correlation between surface area and drug release rate was confirmed, supporting the predictions of the Noyes-Whitney equation. Differential Scanning Calorimetry (DSC) and Scanning Electron Microscope (SEM) analyses verified the uniform dispersion of acetaminophen and the consistency of the internal structures, respectively. Conclusions The precise control of tablet surface geometry effectively tailored drug release profiles, enhancing patient compliance and treatment efficacy. This novel approach offers significant advancements in personalized medicine by providing a highly reproducible and adaptable platform for optimizing drug delivery. Graphical Abstract

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Development of Mathematical Function Control-Based 3D Printed Tablets and Effect on Drug Release

Wang,

Karnik,

Uttreja

et al. 2024

Pharm Res

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Fabrication of osmotic pump tablets utilizing semisolid extrusion three-dimensional printing technology

Chen,

Fang,

Wang

et al. 2024

International Journal of Pharmaceutics

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Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling Technology

Cited by 2 publications

References 67 publications

Development of Mathematical Function Control-Based 3D Printed Tablets and Effect on Drug Release

Development of Mathematical Function Control-Based 3D Printed Tablets and Effect on Drug Release

Fabrication of osmotic pump tablets utilizing semisolid extrusion three-dimensional printing technology

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