Fabrication of Carbonate Apatite Block through a Dissolution–Precipitation Reaction Using Calcium Hydrogen Phosphate Dihydrate Block as a Precursor

Tsuru, Kanji; Yoshimoto, Ayami; Kanazawa, Masanori; Sugiura, Yuki; Nakashima, Yasuharu; Ishikawa, Kunio

doi:10.3390/ma10040374

Cited by 39 publications

(27 citation statements)

References 18 publications

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“…CO 3 Ap decomposes at 400°C and pronounced thermal decomposition occurs at 600-700°C [3]. An alternative method was proposed to fabricate CO 3 Ap scaffolds using a dissolution-precipitation reaction during hydrothermal treatment [4,[6][7][8][9]. Apart from hydrothermal treatment, other methods such as carbonation [10], phosphorization [2] and hydrolysis [11] were able to fabricate CO 3 Ap.…”

Section: Introductionmentioning

confidence: 99%

“…The hydrothermal treatment in production of CO 3 Ap scaffolds was applied for the first time in 2007. The precursors used in previous works are varied; for example, calcite (CaCO 3 ) [2], gypsum [3], calcium hydrogen phosphate dehydrate (DCPA) [9] and alpha-tricalcium phosphate (α-TCP) [1,8,12]. The selection of the precursors is based on their chemical and physical properties.…”

Section: Introductionmentioning

confidence: 99%

“…The selection of the precursors is based on their chemical and physical properties. The precursor should have at least one component of CO 3 Ap, such as calcium, phosphate or carbonate group [9]. Table 1 summarizes the precursors used by previous researchers to fabricate a CO 3 Ap scaffold by hydrothermal treatment [1][2][3]8,9,12].…”

Section: Introductionmentioning

confidence: 99%

“…The precursor should have at least one component of CO 3 Ap, such as calcium, phosphate or carbonate group [9]. Table 1 summarizes the precursors used by previous researchers to fabricate a CO 3 Ap scaffold by hydrothermal treatment [1][2][3]8,9,12]. α-TCP powder has commonly been used as a precursor to fabricate CO 3 Ap scaffolds due to its high solubility, as reported by Tsuru et al [13].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Darus

Jaafar

Ahmad

2019

PAC

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The aim of this study is to fabricate CO 3 Ap scaffolds using a dissolution-precipitation reaction during hydrothermal treatment. Beta-tricalcium phosphate (β-TCP) was used as a precursor instead of the commonly used alpha-tricalcium phosphate (α-TCP). Here, the CO 3 Ap scaffold fabrication was accomplished in two steps: i) fabrication of β-TCP scaffold using a combination of direct foaming and a sacrificial template and ii) hydrothermal conversion of the β-TCP scaffold at 200°C in 2 mol/l NaHCO 3 and Na 2 CO 3 aqueous solutions for 2-10 days. The effect of two different solutions was identified in the dissolution-precipitation reaction. CO 3 Ap scaffold with 8.95 wt.% carbonate content was successfully fabricated using a NaHCO 3 solution. The average pore size of the scaffold was approximately 180 µm with 72% porosity. The average compressive strength of the CO 3 Ap scaffold was 0.7 MPa. Based on the compressive strength and carbonate content results, NaHCO 3 aqueous solutions were chosen as carbonate sources for phase transformation to fabricate a CO 3 Ap scaffold over 6 days.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Darus

Jaafar

Ahmad

2019

PAC

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“…A presença do grupo CO3 2relaciona-se a sistemas de apatitas carbonatadas. A hidroxiapatita sintética se assemelha à apatita carbonatada biológica, que pode apresentar de 6 a 9 % em peso de íons CO3 2substituídos em sua estrutura (TSURU et al, 2017).…”

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Influência da zircônia na deposição biomimética de fosfatos de cálcio sobre a superfície de nanocompósitos de alumina-zircônia

Sartori¹

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Agradeço a Deus e a Espiritualidade pela luz em cada etapa percorrida durante essa jornada de aprendizado científico, mas sobretudo, de desenvolvimento pessoal. "Entrega o teu caminho ao Senhor. Confia nele e o mais ele fará..." A minha orientadora, Prof. Dra. Elíria M. J. Agnolon Pallone, pelo incentivo, orelha, disponibilidade e orientação acadêmica. Mas sobretudo, por sempre me impulsionar a crescer no âmbito profissional e pessoal. A minha coorientadora, Dra. Julieta A. Ferreira, pela prestatividade em meus cursos de mestrado e doutorado. A professora Denise Osiro, por compartilhar seu vasto conhecimento e abrir portas para novas parcerias do grupo. Agradeço imensamente pelo auxílio na compreensão e discussão dos resultados de FT-MIR deste estudo. Aos funcionários do departamento de Engenharia de Biossistemas (ZEB) e ao Setor de Pósgraduação, de forma especial, ao Programa de Engenharia e Ciência de Materiais, que sempre me foram gentis no dia-a-dia ao longo dos meus cursos de mestrado e doutorado.

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Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

Akita

Fukuda

Kamada

et al. 2019

J Biomedical Materials Res

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Carbonate apatite (CO 3 Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO 3 Ap granules through a twostep dissolution-precipitation reaction using CaSO 4 as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO 3 Ap. Porous CO 3 Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO 3 Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO 3 Ap (120) [porous CO 3 Ap granules made using 120-μm microfiber] followed by CO 3 Ap (50) and CO 3 Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO 3 Ap (120). It is concluded, therefore, that the optimal pore size of the CO 3 Ap is that of CO 3 Ap (120), which is 85 μm. K E Y W O R D Sbone formation, bone substitute, carbonate apatite, hydroxyapatite, optimal pore size

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Fabrication of Carbonate Apatite Block through a Dissolution–Precipitation Reaction Using Calcium Hydrogen Phosphate Dihydrate Block as a Precursor

Cited by 39 publications

References 18 publications

Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Influência da zircônia na deposição biomimética de fosfatos de cálcio sobre a superfície de nanocompósitos de alumina-zircônia

Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

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