Nanostructured metal oxide semiconductors (MOS) in the form of thin film or bulk attract significant interest of materials researchers in both basic and applied sciences. Among these important MOSs, indium oxide (IO) is a valuable one due to its novel properties and wide range of applications in diversified fields. IO based nanostructured thin films possess excellent visible transparency, metal-like electrical conductivity and infrared reflectance properties. This chapter mainly highlights the synthesis strategies of IO based bulk nanomaterials with variable morphologies starting from spherical nanoparticles to nano-rods, nano-wires, nano-needles, nanopencils, nanopushpins etc. In addition, thin film deposition and periodic 1-dimensional (1D)/2-dimensional (2D) surface texturing techniques of IO based nanostructured thin films vis-à-vis their functional properties and applications have been discussed. The chapter covers a state-of-the-art survey on the fabrication strategies and recent advancement in the properties of IO based nanomaterials with their different areas of applications. Finally, the challenges and future prospect of IO based nanomaterials have been discussed briefly.