Fabry–Perot fiber-optic immunosensor based on suspended layer-by-layer (chitosan/polystyrene sulfonate) membrane

Chen, L.H.; Chan, Chi Chiu; Menon, Rajesh; Balamurali, P.; Wong, Wei Chang; Ang, Xiu Min; Hu, Pengbing; Shaillender, M.; Neu, Björn; Zu, Peng; Tou, Zhi Qiang; Poh, Chueh Loo; Leong, K. C.

doi:10.1016/j.snb.2013.06.093

Cited by 37 publications

(22 citation statements)

References 24 publications

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“…The simple optical setup is advantageous compared with other interferometer systems and is by these multiple reflections very useful for measuring vertically independent even large molecules or cells or membranes. Unlike in evanescent field detection methods, the interaction between radiation and matter is independent of radiation propagation [382]. Reflectometric interference spectroscopy is combined with quartz micro balance to have a useful tool to quantitatively analyze molecular adsorption of vesicles on various surfaces [59].…”

Section: Reflectometric Interference Spectroscopymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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Section: Reflectometric Interference Spectroscopymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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“…The simple structure of the FPI allows it to be easily combined with a microfluidic system and integrated with other optical materials or components such as a porous silicon or an optical fiber [ 35 , 36 , 37 , 38 ]. FPI-based biosensors boast a high sensitivity compared to other interferometric biosensors based on Mach-Zehnder and Michelson interferometers due to its resonance characteristic through a large number of reflections [ 39 , 40 ].…”

Section: Fabry-perot Interferometer (Fpi)-based Biosensorsmentioning

confidence: 99%

“…There have been efforts to develop optical biosensors utilizing the simple structure of FPI to have characteristics such as an easy fabrication process, simple test setup, and cost-effectiveness [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. For example, You et al developed a microfluidic enhanced FPI-based biosensor to detect glucose, sodium chloride (NaCl), and potassium chloride (KCl) for diabetes patients [ 37 ].…”

Section: Fabry-perot Interferometer (Fpi)-based Biosensorsmentioning

confidence: 99%

“…An optical fiber was originally developed to guide light waves along the core, which is surrounded by a cladding layer through the total internal reflection at the interface with negligible loss. Over the last few decades, optical fibers have been extensively investigated for biosensing applications, with the intrinsic advantages including flexibility, low-cost, small size, and biocompatibility [ 39 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ]. To be developed as a biosensor, the structure of optical fiber has modified to maximize the interaction of light with target analytes and increase the sensitivity [ 66 ].…”

Section: Fabry-perot Interferometer (Fpi)-based Biosensorsmentioning

confidence: 99%

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Label-Free Optical Resonator-Based Biosensors

Rho

Breaux

Kim

2020

Sensors

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The demand for biosensor technology has grown drastically over the last few decades, mainly in disease diagnosis, drug development, and environmental health and safety. Optical resonator-based biosensors have been widely exploited to achieve highly sensitive, rapid, and label-free detection of biological analytes. The advancements in microfluidic and micro/nanofabrication technologies allow them to be miniaturized and simultaneously detect various analytes in a small sample volume. By virtue of these advantages and advancements, the optical resonator-based biosensor is considered a promising platform not only for general medical diagnostics but also for point-of-care applications. This review aims to provide an overview of recent progresses in label-free optical resonator-based biosensors published mostly over the last 5 years. We categorized them into Fabry-Perot interferometer-based and whispering gallery mode-based biosensors. The principles behind each biosensor are concisely introduced, and recent progresses in configurations, materials, test setup, and light confinement methods are described. Finally, the current challenges and future research topics of the optical resonator-based biosensor are discussed.

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“…This is mostly due to the electrostatic unspecific adsorption of both target and interfering biomolecules onto the charged LbL layers. As a matter of fact, the only two works that have been reported to date on the use of LbL assembly for label-free optical biosensing rely on the electrostatic and unspecific immobilization of bioreceptors onto the charged polyelectrolytes of the LbL assembly, either IgG antibodies for the anti-IgG detection with a fiber-optic Fabry-Perot interferometer 28 or aptamer-probes for C-reactive protein (CRP) detection with a lossy-mode-resonance optical fiber 29 . In both cases, no data were provided to rule out unspecific electrostatic interaction between target analytes and charged polyelectrolytes without bioreceptors.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing

et al. 2018

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Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization for the binding of bioreceptors becomes a complex issue that can affect the performance of label-free biosensors. Here we report on an effective and robust route for surface biofunctionalization of nanostructured materials based on the layer-by-layer (LbL) electrostatic nano-assembly of oppositely-charged polyelectrolytes, which are engineered with bioreceptors to enable label-free detection of target analytes. LbL biofunctionalization is demonstrated using nanostructured porous silicon (PSi) interferometers for affinity detection of streptavidin in saliva, through LbL nano-assembly of a bi-layer of positively-charged poly(allylamine hydrochloride) (PAH) and negatively-charged biotinylated poly(methacrylic acid) (b-PMAA). High sensitivity in streptavidin detection is achieved, with high selectivity and stability, down to a detection limit of 600 fM.

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Fabry–Perot fiber-optic immunosensor based on suspended layer-by-layer (chitosan/polystyrene sulfonate) membrane

Cited by 37 publications

References 24 publications

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Label-Free Optical Resonator-Based Biosensors

Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing

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