Facial allergic contact dermatitis caused by caprylic/capric triglyceride in a cosmetic cream

Khan, Wajeeha; Stone, Natalie

doi:10.1111/cod.14019

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Although it has not been proven, there could be a cross‐reaction between the two allergens, although this should be interpreted with caution. Allergic contact dermatitis to capric/caprylic triglyceride present in cosmetics has been reported in the literature 4,5 . Oleoyl tyrosine, which is an AAAA, has recently been reported as a new allergen present in sunscreens 6 …”

Section: Main Textmentioning

confidence: 99%

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Allergic contact dermatitis caused by capryloyl glycine in an atopic dermatitis patient

2022

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Section: Main Textmentioning

confidence: 99%

“…Allergic contact dermatitis to capric/caprylic triglyceride present in cosmetics has been reported in the literature. 4,5 Oleoyl tyrosine, which is an AAAA, has recently been reported as a new allergen present in sunscreens. 6…”

Section: Main Textmentioning

confidence: 99%

Allergic contact dermatitis caused by capryloyl glycine in an atopic dermatitis patient

2022

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“…CHS is a prevalent occupational dermatological condition, affecting approximately 15–20% of the general adult population. It is frequently caused by fragrant cosmetics, with stabilizing and texture agents being the two most significant allergens found in these products [ 2 , 3 , 4 , 5 ]. Additional triggers include a variety of workplace and lifestyle items like metals, detergents, rubber gloves, jewelry, and dyes [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Berry Extracts and Their Bioactive Compounds Mitigate LPS and DNFB-Mediated Dendritic Cell Activation and Induction of Antigen Specific T-Cell Effector Responses

Upadhaya,

Lamenza,

Shrestha

et al. 2023

Antioxidants

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Berries have gained widespread recognition for their abundant natural antioxidant, anti-inflammatory, and immunomodulatory properties. However, there has been limited research conducted thus far to investigate the role of the active constituents of berries in alleviating contact hypersensitivity (CHS), the most prevalent occupational dermatological disease. Our study involved an ex vivo investigation aimed at evaluating the impact of black raspberry extract (BRB-E) and various natural compounds found in berries, such as protocatechuic acid (PCA), proanthocyanidins (PANT), ellagic acid (EA), and kaempferol (KMP), on mitigating the pathogenicity of CHS. We examined the efficacy of these natural compounds on the activation of dendritic cells (DCs) triggered by 2,4-dinitrofluorobenzene (DNFB) and lipopolysaccharide (LPS). Specifically, we measured the expression of activation markers CD40, CD80, CD83, and CD86 and the production of proinflammatory cytokines, including Interleukin (IL)-12, IL-6, TNF-α, and IL-10, to gain further insights. Potential mechanisms through which these phytochemicals could alleviate CHS were also investigated by investigating the role of phospho-ERK. Subsequently, DCs were co-cultured with T-cells specific to the OVA323-339 peptide to examine the specific T-cell effector responses resulting from these interactions. Our findings demonstrated that BRB-E, PCA, PANT, and EA, but not KMP, inhibited phosphorylation of ERK in LPS-activated DCs. At higher doses, EA significantly reduced expression of all the activation markers studied in DNFB- and LPS-stimulated DCs. All compounds tested reduced the level of IL-6 in DNFB-stimulated DCs in Flt3L as well as in GM-CSF-derived DCs. However, levels of IL-12 were reduced by all the tested compounds in LPS-stimulated Flt3L-derived BMDCs. PCA, PANT, EA, and KMP inhibited the activated DC-mediated Interferon (IFN)-γ and IL-17 production by T-cells. Interestingly, PANT, EA, and KMP significantly reduced T-cell proliferation and the associated IL-2 production. Our study provides evidence for differential effects of berry extracts and natural compounds on DNFB and LPS-activated DCs revealing potential novel approaches for mitigating CHS.

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Facial allergic contact dermatitis caused by caprylic/capric triglyceride in a cosmetic cream

Cited by 2 publications

References 5 publications

Allergic contact dermatitis caused by capryloyl glycine in an atopic dermatitis patient

Allergic contact dermatitis caused by capryloyl glycine in an atopic dermatitis patient

Berry Extracts and Their Bioactive Compounds Mitigate LPS and DNFB-Mediated Dendritic Cell Activation and Induction of Antigen Specific T-Cell Effector Responses

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